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The interplay of mutations and electronic properties in disease-related genes
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Shih, Chi-Tin, Wells, Stephen A., Hsu, Ching-Ling, Cheng, Yun-Yin and Römer, Rudolf A. (2012) The interplay of mutations and electronic properties in disease-related genes. Scientific Reports, Vol.2 (No.272). doi:10.1038/srep00272 ISSN 2045-2322.
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Official URL: http://dx.doi.org/10.1038/srep00272
Abstract
Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have implications for the role of the electronic properties of DNA in cellular processes, and hint at the possibility of prediction, early diagnosis and detection of mutation hotspots.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Science > Centre for Scientific Computing |
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Library of Congress Subject Headings (LCSH): | DNA -- Electric properties, Mutation (Biology), Medical genetics | ||||
Journal or Publication Title: | Scientific Reports | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 2045-2322 | ||||
Official Date: | 15 February 2012 | ||||
Dates: |
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Volume: | Vol.2 | ||||
Number: | No.272 | ||||
DOI: | 10.1038/srep00272 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 19 December 2015 | ||||
Date of first compliant Open Access: | 19 December 2015 | ||||
Funder: | Guo jia ke xue wei yuan hui [National Science Council (Taiwan)], Leverhulme Trust (LT) | ||||
Grant number: | 97-2112-M-029-002-MY3 (NSC), 100-2112-M-029-001-MY3 (NSC), F/00215/AH (LT) |
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