The Library
Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity
Tools
Howson, Suzanne E., Bolhuis, Albert, Brabec, V., Clarkson, Guy J., Malina, J., Rodger, Alison and Scott, Peter (2011) Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity. Nature Chemistry, 4 (1). pp. 31-36. doi:10.1038/nchem.1206 ISSN 1755-4330.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1038/nchem.1206
Abstract
The helicates—chiral assemblies of two or more metal atoms linked by short or relatively rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices because they are of comparable size and have shown some relevant biological activity. Unfortunately, these beautiful helical compounds have remained difficult to use in the medicinal arena because they contain mixtures of isomers, cannot be optimized for specific purposes, are insoluble, or are too difficult to synthesize. Instead, we have now prepared thermodynamically stable single enantiomers of monometallic units connected by organic linkers. Our highly adaptable self-assembly approach enables the rapid preparation of ranges of water-stable, helicate-like compounds with high stereochemical purity. One such iron(II) ‘flexicate’ system exhibits specific interactions with DNA, promising antimicrobial activity against a Gram-positive bacterium (methicillin-resistant Staphylococcus aureus, MRSA252), but also, unusually, a Gram-negative bacterium (Escherichia coli, MC4100), as well as low toxicity towards a non-mammalian model organism (Caenorhabditis elegans).
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Nature Chemistry | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1755-4330 | ||||
Official Date: | 2011 | ||||
Dates: |
|
||||
Volume: | 4 | ||||
Number: | 1 | ||||
Page Range: | pp. 31-36 | ||||
DOI: | 10.1038/nchem.1206 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |