The Library
C-Peptide and its Intracellular Signaling
Tools
Hills, Claire E. and Brunskill, Nigel J. (2009) C-Peptide and its Intracellular Signaling. Review of Diabetic Studies, Vol.6 (No.3). pp. 138-147. doi:10.1900/RDS.2009.6.138 ISSN 1613-6071.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1900/RDS.2009.6.138
Abstract
Although long believed to be inert, C-peptide has now been shown to have definite biological effects both in vitro and in vivo in diabetic animals and in patients with type 1 diabetes. These effects point to a protective action of C-peptide against the development of diabetic microvascular complications. Underpinning these observations is undisputed evidence of C-peptide binding to a variety of cell types at physiologically relevant concentrations, and the downstream stimulation of multiple cell signaling pathways and gene transcription via the activation of numerous transcription factors. These pathways affect such fundamental cellular processes as re-absorptive and/or secretory phenotype, migration, growth, and survival. Whilst the receptor remains to be identified, experimental data points strongly to the existence of a specific G-protein-coupled receptor for C-peptide. Of the cell types studied so far, kidney tubular cells express the highest number of C-peptide binding sites. Accordingly, C-peptide exerts major effects on the function of these cells, and in the context of diabetic nephropathy appears to antagonise the pathophysiological effects of major disease mediators such as TGFβ1 and TNFα. Therefore, based on its cellular activity profile C-peptide appears well positioned for development as a therapeutic tool to treat microvascular complications in type 1 diabetes.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > Q Science (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Review of Diabetic Studies | ||||
Publisher: | Society for Biomedical Diabetes Research (S B D R) | ||||
ISSN: | 1613-6071 | ||||
Official Date: | 2009 | ||||
Dates: |
|
||||
Volume: | Vol.6 | ||||
Number: | No.3 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 138-147 | ||||
DOI: | 10.1900/RDS.2009.6.138 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |