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Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1
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Yamada, Eijiro, Pessin, Jeffrey E., Kurland, Irwin J., Schwartz, Gary J. and Bastie, Claire C. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metabolism, Vol.11 (No.2). pp. 113-124. doi:10.1016/j.cmet.2009.12.010 ISSN 1550-4131.
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Official URL: http://dx.doi.org/10.1016/j.cmet.2009.12.010
Abstract
Fyn null mice display reduced adiposity associated with increased fatty acid oxidation, energy expenditure, and activation of the AMP-dependent protein kinase (AMPK) in skeletal muscle and adipose tissue. The acute pharmacological inhibition of Fyn kinase activity with SU6656 in wild-type mice reproduces these metabolic effects and induced a specific reduction in fat mass with no change in lean mass. LKB1, the main upstream AMPK kinase (AMPKK) in peripheral tissues, was redistributed from the nucleus into the cytoplasm of cells treated with SU6656 and in cells expressing a kinase-deficient, but not a constitutively kinase-active, Fyn mutant. Moreover, Fyn kinase directly phosphorylated LKB1 on tyrosine 261 and 365 residues, and mutations of these sites resulted in LKB1 export into the cytoplasm and increased AMPK phosphorylation. These data demonstrate a crosstalk between Fyn tyrosine kinase and the AMPK energy-sensing pathway, through Fyn-dependent regulation of the AMPK upstream activator LKB1.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Cell Metabolism | ||||
Publisher: | Cell Press | ||||
ISSN: | 1550-4131 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.11 | ||||
Number: | No.2 | ||||
Page Range: | pp. 113-124 | ||||
DOI: | 10.1016/j.cmet.2009.12.010 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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