The Library
Uncovering interactions in the frequency domain
Tools
Guo, Shuixia, Wu, Jianhua, Ding, Mingzhou and Feng, Jianfeng (2008) Uncovering interactions in the frequency domain. P L o S Computational Biology , Vol.4 (No.5). doi:10.1371/journal.pcbi.1000087 ISSN 1553-734X.
|
PDF
WRAP_Feng_Uncovering_Interactions.pdf - Requires a PDF viewer. Download (695Kb) |
Official URL: http://dx.doi.org/10.1371/journal.pcbi.1000087
Abstract
Oscillatory activity plays a critical role in regulating biological processes at levels ranging from subcellular, cellular, and
network to the whole organism, and often involves a large number of interacting elements. We shed light on this issue by
introducing a novel approach called partial Granger causality to reliably reveal interaction patterns in multivariate data with
exogenous inputs and latent variables in the frequency domain. The method is extensively tested with toy models, and
successfully applied to experimental datasets, including (1) gene microarray data of HeLa cell cycle; (2) in vivo multielectrode
array (MEA) local field potentials (LFPs) recorded from the inferotemporal cortex of a sheep; and (3) in vivo LFPs
recorded from distributed sites in the right hemisphere of a macaque monkey.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Centre for Scientific Computing Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Science > Mathematics |
||||
Library of Congress Subject Headings (LCSH): | Oscillations, Biological systems, Biology -- Mathematical models, DNA microarrays -- Data processing, Brain -- Data processing | ||||
Journal or Publication Title: | P L o S Computational Biology | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1553-734X | ||||
Official Date: | 30 May 2008 | ||||
Dates: |
|
||||
Volume: | Vol.4 | ||||
Number: | No.5 | ||||
DOI: | 10.1371/journal.pcbi.1000087 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year