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The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus : what do we know today?
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Barber, T. M. and Franks, Stephen (2012) The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus : what do we know today? Women's Health, Vol.8 (No.2). pp. 147-154. doi:10.2217/whe.11.94 ISSN 1745-5057.
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Official URL: http://dx.doi.org/10.2217/whe.11.94
Abstract
Polycystic ovary syndrome (PCOS) and Type 2 diabetes mellitus (T2D) are both obesity-related conditions that share epidemiological and pathophysiological factors. Insulin resistance is a key factor whereby obesity influences the expression of each condition. However, the mechanisms by which insulin resistance contributes towards the manifestation of PCOS and T2D differ in important ways: in PCOS, compensatory hyperinsulinemia results in pleiotropic effects including co-gonadotrophic stimulation of ovarian and adrenal steroidogenesis; in T2D, insulin resistance contributes towards β-cell exhaustion and ultimately to hyposecretion of insulin with resultant dysglycemia. The link between PCOS and Type 1 diabetes mellitus is believed to implicate supraphysiological concentrations of insulin within the systemic circulation. Further progression of the obesity epidemic will ensure even greater prominence of important obesity-related conditions such as PCOS and T2D. Research to gain a clearer understanding of the mechanisms linking each condition should be a priority. © 2012 Future Medicine Ltd.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Women's Health | ||||
Publisher: | Future Medicine | ||||
ISSN: | 1745-5057 | ||||
Official Date: | March 2012 | ||||
Dates: |
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Volume: | Vol.8 | ||||
Number: | No.2 | ||||
Page Range: | pp. 147-154 | ||||
DOI: | 10.2217/whe.11.94 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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