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A simple matter of life and death : the trials of postnatal beta-cell mass regulation
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Tarabra, Elena, Pelengaris, Stella and Khan, Michael (2012) A simple matter of life and death : the trials of postnatal beta-cell mass regulation. International Journal of Endocrinology, Vol.2012 . Article no. 516718. doi:10.1155/2012/516718 ISSN 1687-8337.
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Official URL: http://dx.doi.org/10.1155/2012/516718
Abstract
Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators of beta-cell mass and a better understanding of the processes of beta-cell differentiation and proliferation may provide further insight for the development of new therapeutic targets for diabetes. This review will focus on the principal hormones and nutrients, as well as downstream signalling pathways regulating beta-cell mass in the adult. Furthermore, we will also address more recently appreciated regulators of beta-cell mass, such as microRNAs.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Pancreatic beta cells -- Synthesis -- Regulation | ||||
Journal or Publication Title: | International Journal of Endocrinology | ||||
Publisher: | Hindawi Publishing Corporation | ||||
ISSN: | 1687-8337 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.2012 | ||||
Page Range: | Article no. 516718 | ||||
DOI: | 10.1155/2012/516718 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 21 December 2015 | ||||
Date of first compliant Open Access: | 21 December 2015 |
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