The Library
Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry
Tools
Hurtado, Pilar Perez and O'Connor, Peter B. (2012) Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry. Mass Spectrometry Reviews, Volume 31 (Number 6). pp. 609-625. doi:10.1002/mas.20357 ISSN 0277-7037.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/mas.20357
Abstract
Characterization and differentiation of isomers in biological macromolecules using mass spectrometry is one of the most significant challenges facing scientists in the field. The capability of high-resolution MS instruments along with the development of new fragmentation methods now provides the ability to indirectly differentiate between some isomers. This ability has enabled mass spectrometry to evolve into a multidisciplinary technique incorporating areas such as pharmaceutical research, proteomics, polymer science, medicine, environmental chemistry, and recently archeology. This article aims to review recent developments in mass spectrometry methodologies in the identification of structural and spatial isomers in biological macromolecules, such as aspartic acid and isoaspartic acid (Asp/IsoAsp), leucine and isoleucine (Leu/Ile), glutamic acid and γ-glutamic acid, and D/L enantiomers. © 2012 Wiley Periodicals, Inc. Mass Spec Rev
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Mass Spectrometry Reviews | ||||
Publisher: | John Wiley & Sons Inc | ||||
ISSN: | 0277-7037 | ||||
Official Date: | December 2012 | ||||
Dates: |
|
||||
Volume: | Volume 31 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 609-625 | ||||
DOI: | 10.1002/mas.20357 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |