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Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides
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Jones, Mathew W., Strickland, Rachel A., Schumacher, Felix F., Caddick, Stephen, Baker, James. R., Gibson, Matthew I. and Haddleton, David M. (2012) Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides. Chemical Communications, Vol.48 (No.34). pp. 4064-4066. doi:10.1039/c2cc30259d ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C2CC30259D
Abstract
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.48 | ||||
Number: | No.34 | ||||
Page Range: | pp. 4064-4066 | ||||
DOI: | 10.1039/c2cc30259d | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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