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Designing organometallic compounds for catalysis and therapy
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Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
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WRAP_Habtemariam486_ChemComm2012_48_5219_Anna Louisa Noffke_deposit.pdf - Accepted Version Download (3095Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/c2cc30678f
Abstract
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation. Electronic and steric effects are used to control both the thermodynamics and kinetics of ligand substitution and redox reactions of metal ions, especially Ru II. Can similar features be incorporated into the design of targeted organometallic drugs? Such complexes offer potential for novel mechanisms of drug action through incorporation of outer-sphere recognition of targets and controlled activation features based on ligand substitution as well as metal- and ligand-based redox processes. We focus here on η 6-arene, η 5-cyclopentadienyl sandwich and half-sandwich complexes of Fe II, Ru II, Os II and Ir III with promising activity towards cancer, malaria, and other conditions. © 2012 The Royal Society of Chemistry.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Organometallic compounds, Antimalarials, Antineoplastic agents, Catalysis, Tumors, Thermodynamics | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 28 May 2012 | ||||
Dates: |
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Volume: | Vol.48 | ||||
Number: | No.43 | ||||
Page Range: | pp. 5219-5246 | ||||
DOI: | 10.1039/c2cc30678f | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | European Research Council (ERC), Economic and Social Research Council (Great Britain) (ESRC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||
Grant number: | 247450 (ERC) |
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