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Sequence-specific synthesis of macromolecules using DNA-templated chemistry
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Milnes, Phillip J., McKee, Mireya L., Bath, Jonathan, Song, Lijiang, Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K. (2012) Sequence-specific synthesis of macromolecules using DNA-templated chemistry. Chemical Communications, Vol.48 (No.45). pp. 5614-5616. doi:10.1039/c2cc31975f ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C2CC31975F
Abstract
Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.48 | ||||
Number: | No.45 | ||||
Page Range: | pp. 5614-5616 | ||||
DOI: | 10.1039/c2cc31975f | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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