The Library
Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells
Tools
UNSPECIFIED (2005) Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells. INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, 19 (5). pp. 395-417. doi:10.1002/acs.856 ISSN 0890-6327.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/acs.856
Abstract
A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan is proposed. This model provides a description of the activity of the drug, and subsequent delivery of active form to the nuclear DNA target. The unknown model parameters are estimated from two-photon laser-scanning microscopy data, which provide concentrations of topotecan (active plus inactive forms) in the extracellular region containing live human breast tumour cells (MCF-7 cell line), the cytoplasm and the nucleus. This determines an output structure for which the model is uniquely identifiable, that is, the unknown parameters are uniquely determined from noise-free, continuous and perfect data. The model allows in silico predictions of the dose dependence of target binding. Copyright © 2005 John Wiley & Sons, Ltd.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | T Technology > TL Motor vehicles. Aeronautics. Astronautics T Technology > TK Electrical engineering. Electronics Nuclear engineering |
||||
Journal or Publication Title: | INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING | ||||
Publisher: | JOHN WILEY & SONS LTD | ||||
ISSN: | 0890-6327 | ||||
Official Date: | June 2005 | ||||
Dates: |
|
||||
Volume: | 19 | ||||
Number: | 5 | ||||
Number of Pages: | 23 | ||||
Page Range: | pp. 395-417 | ||||
DOI: | 10.1002/acs.856 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |