The Library
Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis
Tools
UNSPECIFIED (2004) Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis. GENE EXPRESSION PATTERNS, 5 (1). pp. 51-60. doi:10.1016/j.modgep.2004.06.007 ISSN 1567-133X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.modgep.2004.06.007
Abstract
This paper reports the cloning of Xenopus laevis, cyclophilin A gene, X-CypA. This study is the first developmental and functional characterisation in vivo of cyclophilin A in a vertebrate. X-CypA belongs to the superfamily of the immunophilin/PPIase proteins that can bind the immunosuppressant drug Cyclosporin A. Sequence analysis showed that X-CypA is highly conserved during evolution. RT-PCR and in situ hybridisation analysis showed that X-CypA expression is regulated during development and its transcripts are found in three major expression domains: nervous system, sensory organs and pronephros. Over-expression of X-CypA in embryos, analysed by in situ hybridisation and RT-PCR, leads to an expansion and disorganisation of the neural crest domain. (C) 2004 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
||||
Journal or Publication Title: | GENE EXPRESSION PATTERNS | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 1567-133X | ||||
Official Date: | November 2004 | ||||
Dates: |
|
||||
Volume: | 5 | ||||
Number: | 1 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 51-60 | ||||
DOI: | 10.1016/j.modgep.2004.06.007 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |