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Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity
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UNSPECIFIED (2004) Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. ORGANIC LETTERS, 6 (22). pp. 3909-3912. doi:10.1021/ol048462v ISSN 1523-7060.
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Official URL: http://dx.doi.org/10.1021/ol048462v
Abstract
[GRAPHICS] A series of structurally simplified luminacin analogues devoid of the epoxide ring are assembled in a stereocontrolled manner from 2,4-dimethoxybenzaldehyde using a syn-selective aldol reaction as the key step. The success of the approach is critically dependent on the nature and extent of the alcohol protecting groups. The synthetic analogues inhibit VEGF-stimulated angiogenesis in an in vitro assay indicating that the epoxide is not essential for biological activity in this compound class.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | ORGANIC LETTERS | ||||
Publisher: | AMER CHEMICAL SOC | ||||
ISSN: | 1523-7060 | ||||
Official Date: | 28 October 2004 | ||||
Dates: |
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Volume: | 6 | ||||
Number: | 22 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 3909-3912 | ||||
DOI: | 10.1021/ol048462v | ||||
Publication Status: | Published |
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