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Corticotropin releasing factor (CRF) peptide family and their receptors: Divergent actions influencing human physiology
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UNSPECIFIED (2004) Corticotropin releasing factor (CRF) peptide family and their receptors: Divergent actions influencing human physiology. CURRENT GENOMICS, 5 (6). pp. 473-481.
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Abstract
Corticotropin-releasing factor (CRF) and its related peptides play a central role in the co-ordination of autonomic. behavioural. cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two G-protein-coupled receptors encoded by separate genes, termed CRF-R1 and -R2. In this review we focus on the structure, phylogeny, and expression of CRF peptide family. We present up-to-date literature on divergent actions of the CRF peptide family, including stress and behaviour, cardiovascular physiology, energy balance and reproduction. We also present a brief overview of CRF receptors including pharmacological aspects and potential therapeutic interventions for CRF receptors.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics |
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Journal or Publication Title: | CURRENT GENOMICS | ||||
Publisher: | BENTHAM SCIENCE PUBL LTD | ||||
ISSN: | 1389-2029 | ||||
Official Date: | August 2004 | ||||
Dates: |
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Volume: | 5 | ||||
Number: | 6 | ||||
Number of Pages: | 9 | ||||
Page Range: | pp. 473-481 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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