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Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models
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Ohuma, E. O., Okiro, E. A., Bett, A., Abwao, John, Were, S., Samuel, Dhan, Vyse, A. J., Gay, N. J., Brown, D. W. G. and Nokes, D. James (2009) Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models. Epidemiology and Infection, Vol.13 (No.2). pp. 227-233. doi:10.1017/S0950268808000848 ISSN 0950-2688.
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Official URL: http://dx.doi.org/10.1017/S0950268808000848
Abstract
We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign and from a comparison sample of 598 children aged 6 months post-campaign. Quantitative measles-specific antibody data were obtained by commercial kit. The estimated proportions of measles-specific antibody negative in children aged 0–4, 5–9 and 10–14 years were 51%, 42% and 27%, respectively, pre- campaign and 18%, 14% and 6%, respectively, post-campaign. We estimate a reduction in the proportion susceptible of 65–78%, with ~85% of the population recorded to have received vaccine. The proportion of ‘weak’ positive individuals rose from 35% pre-campaign to 54% post-campaign. Our results confirm the effectiveness of the campaign in reducing susceptibility to measles and demonstrate the potential of oral-fluid studies to monitor the impact of measles vaccination campaigns.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Vaccination of children -- Kenya, Communicable diseases -- Prevention, Measles -- Vaccination -- Kenya, Immunoglobulins | ||||
Journal or Publication Title: | Epidemiology and Infection | ||||
Publisher: | Cambridge University Press | ||||
ISSN: | 0950-2688 | ||||
Official Date: | February 2009 | ||||
Dates: |
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Volume: | Vol.13 | ||||
Number: | No.2 | ||||
Page Range: | pp. 227-233 | ||||
DOI: | 10.1017/S0950268808000848 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Wellcome Trust (London, England) | ||||
Grant number: | 061584 (Wellcome) |
Data sourced from Thomson Reuters' Web of Knowledge
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