2020

Louka, Savvas, Barry, Sarah M., Heyes, Derren J., Mubarak, M. Qadri E., Ali, Hafiz Saqib, Alkhalaf, Lona M., Munro, Andrew W., Scrutton, Nigel S., Challis, Gregory L. and de Visser, Sam P. (2020) Catalytic mechanism of aromatic nitration by cytochrome P450 TxtE : involvement of a ferric-peroxynitrite intermediate. Journal of the American Chemical Society, 142 (37). pp. 15764-15779. doi:10.1021/jacs.0c05070

2018

Alkhalaf, Lona M., Barry, Sarah M., Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R., Fülöp, Vilmos and Challis, Gregory L. (2018) Binding of distinct substrate conformations enables hydroxylation of remote sties in thaxtomin D by cytochrome P450 TxtC. Journal of the American Chemical Society . doi:10.1021/jacs.8b08864 (In Press)

Perry, Christopher, de los Santos, Emmanuel L. C., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis. Natural Product Reports, 35 (7). pp. 622-632. doi:10.1039/c8np00004b

Ronan, Jade L., Kadi, Nadia, McMahon, Stephen A., Naismith, James H., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Desferrioxamine biosynthesis : diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1748). doi:10.1098/rstb.2017.0068

2016

Zhou, Shanshan, Alkhalaf, Lona M., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2016) Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis. Current Opinion in Chemical Biology, 35 . pp. 73-79. doi:10.1016/j.cbpa.2016.08.021

Du, Yi-Ling, Singh, Rahul, Alkhalaf, Lona M., Kuatsjah, Eugene, He, Hai-Yan, Eltis, Lindsay D. and Ryan, Katherine S. (2016) A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology, 12 (3). pp. 194-199. doi:10.1038/nchembio.2009