2023

Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M. and Challis, Gregory L. (2023) Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic Acids Research, 51 (3). pp. 1488-1499. doi:10.1093/nar/gkad009 ISSN 1362-4962.

2021

Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J. , Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L. and Corre, Christophe (2021) Molecular basis for control of antibiotic production by a bacterial hormone. Nature, 590 (7846). pp. 463-467. doi:10.1038/s41586-021-03195-x ISSN 0028-0836.

2020

Louka, Savvas, Barry, Sarah M., Heyes, Derren J., Mubarak, M. Qadri E., Ali, Hafiz Saqib, Alkhalaf, Lona M., Munro, Andrew W., Scrutton, Nigel S., Challis, Gregory L. and de Visser, Sam P. (2020) Catalytic mechanism of aromatic nitration by cytochrome P450 TxtE : involvement of a ferric-peroxynitrite intermediate. Journal of the American Chemical Society, 142 (37). pp. 15764-15779. doi:10.1021/jacs.0c05070 ISSN 0002-7863.

2019

Alkhalaf, Lona M., Barry, Sarah M., Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R., Fülöp, Vilmos and Challis, Gregory L. (2019) Binding of distinct substrate conformations enables hydroxylation of remote sties in thaxtomin D by cytochrome P450 TxtC. Journal of the American Chemical Society, 141 (1). pp. 216-222. doi:10.1021/jacs.8b08864 ISSN 0002-7863.

2018

Perry, Christopher, de los Santos, Emmanuel L. C., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis. Natural Product Reports, 35 (7). pp. 622-632. doi:10.1039/c8np00004b ISSN 0265-0568.

Ronan, Jade L., Kadi, Nadia, McMahon, Stephen A., Naismith, James H., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Desferrioxamine biosynthesis : diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1748). doi:10.1098/rstb.2017.0068 ISSN 1471-2970.

2016

Zhou, Shanshan, Alkhalaf, Lona M., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2016) Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis. Current Opinion in Chemical Biology, 35 . pp. 73-79. doi:10.1016/j.cbpa.2016.08.021 ISSN 1367-5931.

Du, Yi-Ling, Singh, Rahul, Alkhalaf, Lona M., Kuatsjah, Eugene, He, Hai-Yan, Eltis, Lindsay D. and Ryan, Katherine S. (2016) A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology, 12 (3). pp. 194-199. doi:10.1038/nchembio.2009 ISSN 1552-4450.