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Number of items: 44.
2022
Chen, Feng, Romero-Canelón, Isolda, Habtemariam, Abraha, Song, Ji-Inn, Banerjee, Samya, Clarkson, Guy J., Song, Lijiang, Prokes, Ivan and Sadler, Peter J. (2022) Effect of cysteine thiols on the catalytic and anticancer activity of Ru(ii) sulfonyl-ethylenediamine complexes. Dalton Transactions, 51 (11). pp. 4447-4457. doi:10.1039/D1DT03856G
2021
Needham, Russell J., Prokes, Ivan, Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, Peter J. (2021) NMR studies of group 8 metallodrugs : 187Os-enriched organo-osmium half-sandwich anticancer complex. Dalton Transactions, 50 (37). pp. 12970-12981. doi:10.1039/d1dt02213j
2020
Challis, Gregory L., Nakou, Ioanna, Jenner, Matthew, Dashti, Yousef, Romero-Canelón, Isolda, Masschelein, Joleen and Mahenthiralingam, Eshwar (2020) Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie International Edition, 59 (51). pp. 23145-23153. doi:10.1002/anie.202009007
Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng, Habtemariam, Abraha and Sadler, Peter J. (2020) Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta, 503 . 119396. doi:10.1016/j.ica.2019.119396
Lam, Yuko P. Y., Wootton, Christopher, Hands-Portman, Ian, Wei, Juan, Chiu, Cookson, Romero-Canelón, Isolda, Lermyte, Frederik, Barrow, Mark P. and O'Connor, Peter B. (2020) Determination of the aggregate binding site of amyloid protofibrils using electron capture dissociation tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, 31 (2). pp. 267-276. doi:10.1021/jasms.9b00053
2019
Shi, Huayun, Wang, Qian, Venkatesh, Venkatesh, Feng, Guokai, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng and Sadler, P. J. (2019) Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide. Dalton Transactions, 48 (24). pp. 8560-8564. doi:10.1039/c9dt00909d
Coverdale, James P. C., Laroiya-McCarron, Thaisa and Romero-Canelón, Isolda (2019) Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates? Inorganics, 7 (3). 31. doi:10.3390/inorganics7030031
2018
Lam, Yuko P. Y., Wootton, Christopher, Hands-Portman, Ian, Wei, Juan, Chiu, Cookson, Romero-Canelón, Isolda, Lermyte, Frederik, Barrow, Mark P. and O'Connor, Peter B. (2018) Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? Chemical Communications, 54 (98). pp. 13853-13856. doi:10.1039/C8CC06675B
Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, Venkatesh, Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, P. J. (2018) Photoactivatable cell-selective dinuclear trans diazido platinum(IV) anticancer prodrugs. Inorganic Chemistry, 57 (22). pp. 14409-14420. doi:10.1021/acs.inorgchem.8b02599
Sanchez-Cano, Carlos, Romero-Canelón, Isolda, Gerakic, Kalotina and Sadler, P. J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014
Sanchez-Cano, Carlos, Romero-Canelón, Isolda, Geraki, Kalotina and Sadler, Peter J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014
Gothe, Yvonne, Romero-Canelón, Isolda, Marzo, Tiziano, Sadler, P. J., Messori, Luigi and Metzler-Nolte, Nils (2018) Synthesis and mode of action studies on Iridium(I)-NHC anticancer drug candidates. European Journal of Inorganic Chemistry, 2018 (20-21). pp. 2461-2470. doi:10.1002/ejic.201800225
Chen, Feng, Romero-Canelón, Isolda, Soldevila-Barreda, Joan J., Song, Ji-Inn, Coverdale, James P. C., Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Wills, Martin, Brabec, Viktor and Sadler, P. J. (2018) Transfer hydrogenation and antiproliferative activity of tethered half-sandwich organoruthenium catalysts. Organometallics, 37 (10). pp. 1555-1566. doi:10.1021/acs.organomet.8b00132
Chen, Feng, Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Coverdale, James P. C., Song, Ji-Inn, Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Brabec, Viktor, Wolny, Juliusz A., Schünemann, Volker and Sadler, P. J. (2018) Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate. Dalton Transactions, 47 (21). 7178-7189 . doi:10.1039/C8DT00438B
Banerjee, Samya, Soldevila-Barreda, Joan J., Wolny, Juliusz A., Wootton, Christopher, Habtemariam, Abraha, Romero-Canelón, Isolda, Chen, Feng, Clarkson, Guy J., Prokes, Ivan, Song, Lijiang, O'Connor, Peter B., Schünemann, Volker and Sadler, P. J. (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science, 9 (12). pp. 3177-3185. doi:10.1039/c7sc05058e
Gatti, Anna, Habtemariam, Abraha, Romero-Canelón, Isolda, Song, Ji-Inn, Heer, Bindy, Clarkson, Guy J., Rogolino, Dominga, Sadler, P. J. and Carcelli, Mauro (2018) Half-sandwich arene ruthenium(II) and osmium(II) thiosemicarbazone complexes : solution behavior and antiproliferative activity. Organometallics, 37 (6). pp. 891-899. doi:10.1021/acs.organomet.7b00875
Larnaudie, Sophie, Brendel, Johannes C., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Catrouillet, Sylvain, Sanchis, Joaquin, Coverdale, James P. C., Song, Ji-Inn, Habtemariam, Abraha, Sadler, P. J., Jolliffe, Katrina A. and Perrier, Sébastien (2018) Cyclic peptide–polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes. Biomacromolecules, 19 (1). pp. 239-247. doi:10.1021/acs.biomac.7b01491
Coverdale, James P. C., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Clarkson, Guy J., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2018) Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells. Nature Chemistry, 10 . pp. 347-354. doi:10.1038/nchem.2918
Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, V., Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, Peter J. (2018) Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs. [Dataset]
Hearn, Jessica M., Hughes, George Marc, Romero-Canelón, Isolda, Munro, Alison F., Rubio-Ruiz, Belén, Liu, Zhe, Carragher, Neil O. and Sadler, P. J. (2018) Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Metallomics, 10 (1). 93-107 . doi:10.1039/C7MT00242D
2017
Gondim, Ana C. S., Romero-Canelón, Isolda, Sousa, Eduardo H.S., Blindauer, Claudia A., Butler, Jennifer S., Romero, Maria, Sanchez-Cano, Carlos, Sousa, Bruno L., Chaves, Renata P., Nagano, Celso S., Cavada, Benildo S. and Sadler, P. J. (2017) The potent anti-cancer activity of Dioclea lasiocarpa lectin. Journal of Inorganic Biochemistry, 175 . pp. 179-189. doi:10.1016/j.jinorgbio.2017.07.011
Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382
Venkatesh, Venkatesh, Mishra, Narendra, Romero-Canelón, Isolda, Vernooij, Robbin, Shi, Huayun, Coverdale, James P. C., Habtemariam, Abraha, Verma, Sandeep and Sadler, P. J. (2017) Supramolecular photoactivatable anticancer hydrogels. Journal of the American Chemical Society, 139 (16). pp. 5656-5659. doi:10.1021/jacs.7b00186
Needham, Russell J., Sanchez-Cano, Carlos, Zhang, Xin, Romero-Canelón, Isolda, Habtemariam, Abraha, Cooper, Margaret S., Meszaros, Levente, Clarkson, Guy J., Blower, Philip J. and Sadler, P. J. (2017) In-cell activation of organo-osmium(II) anticancer complexes. Angewandte Chemie International Edition, 56 (4). pp. 1017-1020. doi:10.1002/anie.201610290
Venkatesh, Venkatesh, Berrocal-Martin, Raul, Wedge, Christopher, Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Song, Ji-Inn, Coverdale, James P. C., Zhang, Pingyu, Clarkson, Guy J., Habtemariam, Abraha, Magennis, Steven W., Deeth, Robert J. and Sadler, P. J. (2017) Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes. Chemical Science, 8 (12). pp. 8271-8278. doi:10.1039/C7SC03216A
2016
Ude, Ziga, Romero-Canelón, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f
Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions, 45 . pp. 13034-13037. doi:10.1039/C6DT01382A
Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Data for Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex. [Dataset]
2015
Soldevila-Barreda, Joan J., Habtemariam, Abraha, Romero-Canelón, Isolda and Sadler, P, J. (2015) Half-sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry, 153 . pp. 322-333. doi:10.1016/j.jinorgbio.2015.10.008
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655
Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582
2014
Suberu, John O., Romero-Canelón, Isolda, Sullivan, Neil F., Lapkin, Alexei and Barker, Guy C. (2014) Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells. ChemMedChem, Volume 9 (Number 12). pp. 2791-2797. doi:10.1002/cmdc.201402285
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f
Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161
Lopez-Clavijo, Andrea, Duque-Daza, Carlos A., Romero-Canelón, Isolda, Barrow, Mark P., Kilgour, David P. A., Rabbani, Naila, Thornalley, Paul J. and O’Connor, Peter B. (2014) Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry. Journal of The American Society for Mass Spectrometry, Volume 25 (Number 4). pp. 673-683. doi:10.1007/s13361-013-0799-2
2013
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a
Romero-Canelón, Isolda, Salassa, Luca and Sadler, P. J. (2013) The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway. Journal of Medicinal Chemistry, Volume 56 (Number 3). pp. 1291-1300. doi:10.1021/jm3017442
2012
Romero-Canelón, Isolda (2012) Design and mechanism of action of organometallic anticancer complexes. PhD thesis, University of Warwick.
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e
This list was generated on Thu May 19 16:39:38 2022 BST.