2020

Grigonyte, Aurelija, Harrison, Christian, Macdonald, Paul R., Montero-Blay, Ariadna, Tridgett, Matthew, Duncan, John, Sagona, Antonia P., Constantinidou, Chrystala, Jaramillo, Alfonso and Millard, Andrew D. (2020) Comparison of CRISPR and marker-based methods for the engineering of Phage T7. Viruses, 12 (2). e193. doi:10.3390/v12020193

2017

Unnikrishnan, Meera, Constantinidou, Chrystala, Palmer, Tracy and Pallen, Mark J. (2017) The enigmatic Esx proteins : looking beyond mycobacteria. Trends in Microbiology, 25 (3). pp. 192-204. doi:10.1016/j.tim.2016.11.004

2015

Millard, Andrew D., Westblade, Lars, LiPuma, John J., Vavikolanu, Kranthi, Read, Timothy, Pallen, Mark J., Burd, Eileen and Constantinidou, Chrystala (2015) Genome Sequence of the Pandoraea apista LMG 16407 Type Strain. Journal of Bacteriology, 3 (6). e01300-e01315. doi:10.1128/genomeA.01300-15

2014

Halachev, Mihail R., Chan, Jacqueline, Constantinidou, Chrystala, Cumley, Nicola, Bradley, Craig, Smith-Banks, Matthew, Oppenheim, Beryl and Pallen, Mark J. (2014) Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumannii in Birmingham, England. Genome Medicine, Volume 6 (Number 11). pp. 1-13. Article number 70. doi:10.1186/s13073-014-0070-x

Quick, Joshua, Cumley, Nicola, Wearn, Christopher M., Niebel, Marc, Constantinidou, Chrystala, Thomas, Christopher M., Pallen, Mark J., Moiemen, Naiem S., Bamford, Amy, Oppenheim, Beryl and Loman, Nicholas J. (2014) Seeking the source of Pseudomonas aeruginosa infections in a recently opened hospital : an observational study using whole-genome sequencing. BMJ Open, Volume 4 (Number 11). Article number e006278. doi:10.1136/bmjopen-2014-006278

Quick, Joshua , Constantinidou, Chrystala, Pallen, Mark J., Oppenheim, Beryl and Loman, Nicholas J. (2014) Draft genome sequence of Elizabethkingia meningoseptica isolated from a traumatic wound. Genome Announcements, Volume 2 (Number 3). Article number e00355-14. doi:10.1128/genomeA.00355-14

Sergeant, Martin J., Constantinidou, Chrystala, Cogan, Tristan A., Bedford, Michael R., Penn, Charles W. and Pallen, Mark J. (2014) Extensive microbial and functional diversity within the chicken cecal microbiome. PLoS ONE , Volume 9 (Number 3). Article number e91941. doi:10.1371/journal.pone.0091941

Bingle, Lewis E. H., Constantinidou, Chrystala, Shaw, Robert K., Islam, Md. Shahidul, Patel, Mala, Snyder, Lori A. S., Lee, David J., Penn, C. W., Busby, Stephen J. W. and Pallen, Mark J. (2014) Microarray analysis of the ler regulon in enteropathogenic and enterohaemorrhagic escherichia coli strains. PLoS One, Volume 9 (Number 1). e80160. doi:10.1371/journal.pone.0080160

Quraishi, M. N., Sergeant, Martin J., Kay, Gemma L., Iqbal, Tariq, Constantinidou, Chrystala, Chan, Jacqueline, Trivedi, Palak J., Ferguson, James W., Adams, David H., Pallen, Mark J. and Hirschfield, Gideon (2014) Probing the microbiota in PSC : the gut adherent microbiota of PSC-IBD is distinct to that of IBD and controls. In: The 65th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2014, Nov 2014. Published in: Hepatology, 60 (S1). 264A-267A. ISSN 0270-9139. doi:10.1002/hep.27470

2013

Gladstone, Rebecca A., Loman, Nicholas J., Constantinidou, Chrystala, Tocheva, Anna S., Jefferies, Johanna M. C., Faust, Saul N., O’Connor, Leigh, Chan, Jacqueline, Pallen, Mark J. and Clarke, Stuart C. (2013) Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine. PLoS One, Volume 8 (Number 5). e64731. doi:10.1371/journal.pone.0064731

(2013) Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One, Volume 8 (Number 4). Article number e60933. doi:10.1371/journal.pone.0060933

Loman, Nicholas J., Constantinidou, Chrystala, Christner, Martin, Rohde, Holger, Chan, Jacqueline, Quick, Joshua, Weir, Jacqueline C., Quince, Christopher, Smith, Geoffrey, Betley, Jason R., Aepfelbacher, Martin and Pallen, Mark J. (2013) A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-Toxigenic Escherichia coli O104:H4. JAMA: The Journal of the American Medical Association, Volume 309 (Number 14). pp. 1502-1510. doi:10.1001/jama.2013.3231

Martin, K., Baddal, B., Mustafa, N., Perry, C., Underwood, A., Constantinidou, Chrystala, Loman, Nicholas J., Kenna, D. T. and Turton, J. F. (2013) Clusters of genetically similar isolates of Pseudomonas aeruginosa from multiple hospitals in the UK. Journal of Medical Microbiology, Volume 62 (Number 7). pp. 988-1000. doi:10.1099/jmm.0.054841-0

2012

Loman, Nicholas J., Constantinidou, Chrystala, Chan, Jacqueline, Halachev, Mihail R., Sergeant, Martin J., Penn, Charles W., Robinson, Esther R. and Pallen, Mark J. (2012) High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity. Nature Reviews Microbiology, 10 (9). pp. 599-606. doi:10.1038/nrmicro2850

Constantinidou, Chrystala, Sergeant, Martin J., Cogan, Tristan, Penn, Charles W. and Pallen, Mark J. (2012) High-throughput sequencing of 16S rRNA gene amplicons : effects of extraction procedure, primer length and annealing temperature. PLoS One, Volume 7 (Number 5). Article number e38094. doi:10.1371/journal.pone.0038094

Loman, Nicholas J., Misra, Raju V., Dallman, Timothy J., Constantinidou, Chrystala, Gharbia, Saheer E., Wain, John and Pallen, Mark J. (2012) Performance comparison of benchtop high-throughput sequencing platforms. Nature Biotechnology, Volume 30 (Number 5). pp. 434-439. doi:10.1038/nbt.2198

Clark, G., Paszkiewicz, K., Hale, J., Weston, V., Constantinidou, Chrystala, Penn, C., Achtman, Mark and McNally, A. (2012) Genomic analysis uncovers a phenotypically diverse but genetically homogeneous Escherichia coli ST131 clone circulating in unrelated urinary tract infections. Journal of Antimicrobial Chemotherapy, Volume 67 (Number 4). pp. 868-877. doi:10.1093/jac/dkr585

Chan, Jacqueline, Halachev, Mihail R., Loman, Nicholas J., Constantinidou, Chrystala and Pallen, Mark J. (2012) Defining bacterial species in the genomic era : insights from the genus Acinetobacter. BMC Microbiology, 12 (1). 302. doi:10.1186/1471-2180-12-302

Kochar, M., Crosatti, M., Harrison, E. M., Rieck, B., Chan, J., Constantinidou, Chrystala, Pallen, Mark J., Ou, H.-Y. and Rajakumar, Kumar (2012) Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant acinetobacter baumannii strain. Antimicrobial Agents and Chemotherapy, volume 56 (Number 4). pp. 1845-1853. doi:10.1128/AAC.05334-11

Chan, Jacqueline, Pallen, Mark J., Oppenheim, Beryl and Constantinidou, Chrystala (2012) Genome sequencing in clinical microbiology. Nature Biotechnology, Volume 30 (Number 11). pp. 1068-1071. doi:10.1038/nbt.2410

Chan, Jacqueline, Pallen, Mark J., Oppenheim, Beryl and Constantinidou, Chrystala (2012) Genome sequencing in clinical microbiology. Nature Biotechnology, Volume 30 (Number 11). pp. 1068-1071. doi:10.1038/nbt.2410

Abrahams, Katherine A., Cox, Jonathan A. G., Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Fernández, Raquel, Alemparte, Carlos, Remuiñán, Modesto J., Barros, David, Ballell, Lluis and Besra, Gurdyal S. (2012) Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB. PLoS One, Volume 7 (Number 12). Article number e52951. doi:10.1371/journal.pone.0052951

2011

Clarke, D. J., Chaudhuri, R. R., Martin, H. M., Campbell, B. J., Rhodes, J. M., Constantinidou, Chrystala, Pallen, Mark J., Loman, Nicholas J., Cunningham, A. F., Browning, D. F. and Henderson, I. R. (2011) Complete genome sequence of the Crohn's disease-associated adherent-invasive escherichia coliStrain HM605. Journal of Bacteriology, Volume 193 (Number 17). Article number 4540. doi:10.1128/JB.05374-11

Zarrilli, R., Giannouli, M., Rocco, F., Loman, Nicholas J., Haines, A. S., Constantinidou, Chrystala, Pallen, Mark J., Triassi, M. and Di Nocera, P. P. (2011) Genome sequences of three acinetobacter baumannii strains assigned to the multilocus sequence typing genotypes ST2, ST25, and ST78. Journal of Bacteriology, Volume 193 (Number 9). pp. 2359-2360. doi:10.1128/JB.00245-11

Li, G., Tivendale, K. A., Liu, P., Feng, Y., Wannemuehler, Y., Cai, W., Mangiamele, P., Johnson, T. J., Constantinidou, Chrystala, Penn, C. W. and Nolan, L. K. (2011) Transcriptome analysis of avian pathogenic Escherichia coli O1 in chicken serum reveals adaptive responses to systemic infection. Infection and Immunity, Volume 79 (Number 5). pp. 1951-1960. doi:10.1128/IAI.01230-10

2010

Cariss, S. J. L., Constantinidou, Chrystala, Patel, M. D., Takebayashi, Y., Hobman, J. L., Penn, C. W. and Avison, M. B. (2010) YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli. Journal of Bacteriology, Volume 192 (Number 13). pp. 3329-3336. doi:10.1128/JB.01352-09

2009

Bailey, A. M., Constantinidou, Chrystala, Ivens, Alasdair, Garvey, M. I., Webber, Mark A., Coldham, N., Hobman, J. L., Wain, J., Woodward, M. J. and Piddock, Laura J. V. (2009) Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. Journal of Antimicrobial Chemotherapy, Volume 64 (Number 5). pp. 973-985. doi:10.1093/jac/dkp320

Moen, Birgitte, Janbu, Astrid Oust, Langsrud, Solveig, Langsrud, Øyvind, Hobman, Jon L., Constantinidou, Chrystala, Kohler, Achim and Rudi, Knut (2009) Global responses of Escherichia colito adverse conditions determined by microarrays and FT-IR spectroscopy. Canadian Journal of Microbiology, Volume 55 (Number 6). pp. 714-728. doi:10.1139/W09-016

2007

Hobman, J. L., Patel, M. D., Hidalgo-Arroyo, G. A., Cariss, S. J. L., Avison, M. B., Penn, C. W. and Constantinidou, Chrystala (2007) Comparative genomic hybridization detects secondary chromosomal deletions in escherichia coli K-12 MG1655 mutants and highlights instability in the flhDC region. Journal of Bacteriology, Volume 189 (Number 24). pp. 8786-8792. doi:10.1128/JB.00977-07

Kamal, N., Dorrell, N., Jagannathan, A., Turner, S. M., Constantinidou, Chrystala, Studholme, David J., Marsden, G., Hinds, J., Laing, K. G., Wren, B. W. and Penn, C. W. (2007) Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the 54-dependent regulon in Campylobacter jejuni. Microbiology, Volume 153 (Number 9). pp. 3099-3111. doi:10.1099/mic.0.2007/007401-0

Tree, Jai J., Ulett, Glenn C., Hobman, Jon L., Constantinidou, Chrystala, Brown, Nigel L., Kershaw, Christopher, Schembri, Mark A., Jennings, Michael P. and McEwan, Alastair G. (2007) The multicopper oxidase (CueO) and cell aggregation in Escherichia coli. Environmental Microbiology, Volume 9 (Number 8). pp. 2110-2116. doi:10.1111/j.1462-2920.2007.01320.x

Filenko, N., Spiro, S., Browning, D. F., Squire, D., Overton, T. W., Cole, J. and Constantinidou, Chrystala (2007) The NsrR regulon of escherichia coli K-12 includes genes encoding the hybrid cluster protein and the periplasmic, respiratory nitrite reductase. Journal of Bacteriology, Volume 189 (Number 12). pp. 4410-4417. doi:10.1128/JB.00080-07

Roe, A. J., Tysall, L., Dransfield, T., Wang, D., Fraser-Pitt, D., Mahajan, A., Constantinidou, Chrystala, Inglis, N., Downing, A., Talbot, R., Smith, D. G. E. and Gally, D. L. (2007) Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157 : H7. Microbiology, Volume 153 (number 5). pp. 1350-1360. doi:10.1099/mic.0.2006/003707-0

2006

Low, Alison S., Holden, Nicola, Rosser, Tracy, Roe, Andrew J., Constantinidou, Chrystala, Hobman, Jon L., Smith, David G. E., Low, J. Christopher and Gally, David L. (2006) Analysis of fimbrial gene clusters and their expression in enterohaemorrhagic Escherichia coli O157:H7. Environmental Microbiology, Volume 8 (Number 6). pp. 1033-1047. doi:10.1111/j.1462-2920.2006.00995.x

Griffiths, L., Overton, T.W., Patel, M.D., Hobman, J.L., Penn, C.W., Cole, J.A. and Constantinidou, Chrystala (2006) Microarray analysis of gene regulation by oxygen, nitrate, nitrite, FNR, NarL and NarP during anaerobic growth of Escherichia coli : new insights into microbial physiology. Biochemical Society Transactions, Volume 34 (Number 1). pp. 104-107. doi:10.1042/BST0340104

2005

Constantinidou, Chrystala (2005) A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, narXL, and narQP as Escherichia coli K12 adapts from aerobic to anaerobic Growth. Journal of Biological Chemistry, Volume 281 (Number 8). pp. 4802-4815. doi:10.1074/jbc.M512312200

Kershaw, C. J., Brown, Nigel L. , Constantinidou, Chrystala, Patel, Mala D. and Hobman, Jon L. (2005) The expression profile of Escherichia coli K-12 in response to minimal, optimal and excess copper concentrations. Microbiology, Volume 151 (Number 4). pp. 1187-1198. doi:10.1099/mic.0.27650-0

1993

Parsons, Nicholas R., Ashton, Peter R., Constantinidou, Chrystala, Cole, Jeffrey A. and Smith, Harry (1993) Identification by mass spectrometry of CMP-NANA in diffusible material released from high Mr blood cell fractions that confers serum resistance on gonococci. Microbial Pathogenesis, Volume 14 (Number 4). pp. 329-335. doi:10.1006/mpat.1993.1032