2022

Connelly, Erin, Lee, Christina, Furner-Pardoe, Jessica, Del Genio, Charo I. and Harrison, Freya (2022) A case study of the Ancientbiotics collaboration. Patterns, 3 (12). 100632. doi:10.1016/j.patter.2022.100632 ISSN 2666-3899.

Bruce, Julie, Oyedemi, Blessing, Parsons, Nick and Harrison, Freya (2022) Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers. Scientific Reports, 12 (1). 19656. doi:10.1038/s41598-022-22700-4 ISSN 2045-2322.

Garcia Maset, Ramón, Hapeshi, Alexia, Hall, Stephen C. L., Dalgliesh, Robert M., Harrison, Freya and Perrier, Sébastien (2022) Evaluation of the antimicrobial activity in host-mimicking media and in vivo toxicity of antimicrobial polymers as functional mimics of AMPs. ACS Applied Materials & Interfaces, 14 (29). pp. 32855-32868. doi:10.1021/acsami.2c05979 ISSN 1944-8252.

Harrison, Freya, Furner-Pardoe, Jessica and Connelly, Erin (2022) An assessment of the evidence for antibacterial activity of stinging nettle (Urtica dioica) extracts. Access Microbiology, 4 (3). 000336. doi:10.1099/acmi.0.000336 ISSN 2516-8290.

Harrington, Niamh, Littler, Jenny and Harrison, Freya (2022) Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung. Applied and Environmental Microbiology, 88 (3). e01789-21. doi:10.1128/AEM.01789-21 ISSN 0099-2240.

2021

(2021) Model systems to study the chronic, polymicrobial infections in cystic fibrosis : current approaches and exploring future directions. mBio, 12 (5). e0176321. doi:10.1128/mBio.01763-21 ISSN 2150-7511.

O'Brien, Thomas James, Hassan, Marwa Mohsen, Harrison, Freya and Welch, Martin (2021) An in vitro model for the cultivation of polymicrobial biofilms under continuous-flow conditions [version 1; peer review: 2 approved]. F1000Research, 10 . p. 801. doi:10.12688/f1000research.55140.1 ISSN 2046-1402.

Harrington, Niamh, Sweeney, Esther, Alav, Ilyas, Allen, Freya, Moat, John and Harrison, Freya (2021) Antibiotic efficacy testing in an ex vivo model of Pseudomonas aeruginosa and Staphylococcus aureus biofilms in the Cystic Fibrosis lung. Journal of Visualized Experiments (167). e62187. doi:10.3791/62187 ISSN 1940-087X.

Sweeney, Esther, Harrington, Niamh, Harley Henriques, Alicia G., Hassan, Marwa M., Crealock-Ashurst, Branagh, Smyth, Alan R., Hurley, Matthew N., Tormo-Mas, María Ángeles and Harrison, Freya (2021) An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection. Microbiology, 167 (1). doi:10.1099/mic.0.000987 ISSN 1350-0872.

2020

Harrington, Niamh, Sweeney, Esther and Harrison, Freya (2020) Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection. Biofilm, 2 . 100024. doi:10.1016/j.bioflm.2020.100024 ISSN 2590-2075.

Sweeney, Esther, Sabnis, Akshay, Edwards, Andrew M. and Harrison, Freya (2020) Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa. Microbiology, 166 (12). pp. 1171-1180. doi:10.1099/mic.0.000995 ISSN 1350-0872.

Anonye, Blessing O., Nweke, Valentine, Furner-Pardoe, Jessica, Gabrilska, Rebecca, Rafiq, Afshan, Ukachukwu, Faith, Bruce, Julie, Lee, Christina, Unnikrishnan, Meera, Rumbaugh, Kendra P., Snyder, Lori A. S. and Harrison, Freya (2020) The safety profile of Bald’s eyesalve for the treatment of bacterial infections. Scientific Reports, 10 (1). 17513. doi:10.1038/s41598-020-74242-2 ISSN 2045-2322.

Hassan, Marwa, Harrington, Niamh, Sweeney, Esther and Harrison, Freya (2020) Predicting antibiotic-associated virulence of pseudomonas aeruginosa using an ex vivo lung biofilm model. Frontiers in Microbiology, 11 . 568510. doi:10.3389/fmicb.2020.568510 ISSN 1664-302X.

Furner-Pardoe, Jessica, Anonye, Blessing O., Cain, Ricky, Moat, John, Ortori, Catherine A., Lee, Christina, Barrett, David A., Corre, Christophe and Harrison, Freya (2020) Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Scientific Reports, 10 (1). 12687. doi:10.1038/s41598-020-69273-8 ISSN 2045-2322.

Connelly, Erin, Del Genio, Charo I., Harrison, Freya and Nacy, Carol A. (2020) Data mining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against infectious agents. mBio, 11 (1). e03136-19. doi:10.1128/mBio.03136-19 ISSN 2150-7511.

2019

Brockhurst, Michael A., Harrison, Freya, Veening, Jan-Willem , Harrison, Ellie , Blackwell, Grace , Iqbal , Zamin and Maclean , Craig (2019) Assessing evolutionary risks of resistance for new antimicrobial therapies. Nature Ecology and Evolution, 3 . pp. 515-517. doi:10.1038/s41559-019-0854-x ISSN 2397-334X.

Harrison, Freya and Connelly, Erin (2019) Could medieval medicine help the fight against antimicrobial resistance? In: Jones, Chris and Kostick, Conor and Oschema, Klaus, (eds.) Making the Medieval Relevant: How Medieval Studies Contribute to Improving our Understanding of the Present. Berlin, Boston: De Gruyter, pp. 113-134. ISBN 9783110546316

2018

Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16). pp. 7330-7344. doi:10.1021/acs.jmedchem.8b00906 ISSN 1520-4804.

Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Data for Biguanide iridium(III) complexes with potent antimicrobial activity. [Dataset]

2017

Davies, Sarah K., Fearn, Sarah, Allsopp, Luke P., Harrison, Freya, Ware, Ecaterina, Diggle, Stephen P., Filloux, Alain, McPhail, David S. and Bundy, Jacob G. (2017) Visualizing antimicrobials in bacterial biofilms : three-dimensional biochemical imaging using TOF-SIMS. mSphere, 2 (4). 2:e00211-17. doi:10.1128/mSphere.00211-17 ISSN 2379-5042.

Harrison, Freya, McNally, Alan, da Silva, Ana C., Heeb, Stephan and Diggle, Stephen P. (2017) Optimised chronic infection models demonstrate that siderophore ‘cheating’ in Pseudomonas aeruginosa is context specific. The ISME Journal, 11 . pp. 2492-2509. doi:10.1038/ismej.2017.103 ISSN 1751-7362.

Mund, Anne, Diggle, Stephen P. and Harrison, Freya (2017) Erratum for Mund et al., "The fitness of pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment". mBio, 8 (3). p. 1. doi:10.1128/mbio.00816-17 ISSN 2150-7511.

Mund, Anne , Diggle, Stephen P., Harrison, Freya and Greenberg, E. Peter (2017) The fitness of pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment. mBio, 8 (3). e00353-17. doi:10.1128/mBio.00353-17 ISSN 2150-7511.

Popat, Roman, Harrison, Freya, da Silva, Ana C., Easton, Scott A. S., McNally, Luke, Williams, Paul and Diggle, Stephen P. (2017) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proceedings of the Royal Society B: Biological Sciences, 284 (1852). 20170200. doi:10.1098/rspb.2017.0200 ISSN 0962-8452.

2016

Granato, Elisa T., Harrison, Freya, Kümmerli, Rolf and Ross-Gillespie, Adin (2016) Do bacterial “virulence factors” always increase virulence? A meta-analysis of pyoverdine production in pseudomonas aeruginosa as a test case. Frontiers in Microbiology, 7 . doi:10.3389/fmicb.2016.01952 ISSN 1664-302X.

Harrison, Freya and Diggle, Stephen P. (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Microbiology, 162 . pp. 1755-1760. doi:10.1099/mic.0.000352 ISSN 1350-0872.

Ruparell, Avika, Dubern, Jean Frederic, Ortori, Cartherine A, Harrison, Freya, Halliday, Nigel M., Emtage, Abigail, Ashawesh, Mahmoud, Laughton, Charles A., Diggle, Stephen P., Williams, P., Barrett, D. A. (David A.) and Hardie, Kim Rachael (2016) The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports, 6 . pp. 1-10. 33101. doi:10.1038/srep33101 ISSN 2045-2322.

Harrison, Freya and Diggle, Stephen P. (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Working Paper. bioRxiv . (Unpublished)

Granato, Elisa T., Harrison, Freya, Kümmerli, Rolf and Ross-Gillespie, Adin (2016) When is a bacterial "virulence factor" really virulent? Working Paper. bioRxiv . (Unpublished)

Popat, Roman, Harrison, Freya, McNally, Luke, Williams, Paul and Diggle, Stephen P. (2016) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Working Paper. bioRxiv . (Unpublished)

Ruparell, Avika, Dubern, Jean Frederic, Ortori, Cartherine A, Harrison, Freya, Halliday, Nigel M, Emtage, Abigail, Ashawesh, Mahmoud, Laughton, Charles A, Diggle, Steve, Williams, Paul, Barrett, David A and Hardie, Kim Rachael (2016) The fitness burden imposed by synthesizing quorum sensing signals. Working Paper. bioRxiv . (Unpublished)

2015

Popat, Roman, Pollitt, Eric J. G., Harrison, Freya, Naghra, Hardeep, Hong, Kar-Wai, Chan, Kok-Gan, Griffin, Ashleigh S., Williams, Paul, Brown, Sam P., West, Stuart A. and Diggle, Stephen P. (2015) Conflict of interest and signal interference lead to the breakdown of honest signaling. Evolution, 69 (9). pp. 2371-2383. doi:10.1111/evo.12751 ISSN 0014-3820.

Harrison, Freya, Roberts, Aled E. L., Gabrilska, Rebecca, Rumbaugh, Kendra P., Lee, Christina and Diggle, Stephen P. (2015) A 1,000-year-old antimicrobial remedy with antistaphylococcal activity. mBio, 6 (4). e01129-15. doi:10.1128/mBio.01129-15 ISSN 2150-7511.

Darch, Sophie E., McNally, Alan, Harrison, Freya, Corander, Jukka, Barr, Helen L., Paszkiewicz, Konrad, Holden, Stephen, Fogarty, Andrew, Crusz, Shanika A. and Diggle, Stephen P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports, 5 . 7649. doi:10.1038/srep07649 ISSN 2045-2322.

2014

Haddad, Anneke D. M., Harrison, Freya, Norman, Thomas and Lau, Jennifer Y.F. (2014) Adolescent and adult risk-taking in virtual social contexts. Frontiers in Psychology, 5 . 1476. doi:10.3389/fpsyg.2014.01476 ISSN 1664-1078.

Harrison, Freya, Muruli, Aneesha, Higgins, Steven and Diggle, Stephen P. (2014) Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of pseudomonas aeruginosa. Infection and Immunity, 82 (8). pp. 3312-3323. doi:10.1128/IAI.01554-14 ISSN 0019-9567.

Barta, Zoltán, Székely, Tamás, Liker, András and Harrison, Freya (2014) Social role specialization promotes cooperation between parents. American Naturalist, 183 (6). pp. 747-761. doi:10.1086/676014 ISSN 0003-0147.

2013

Moore, David, Wigby, Stuart, English, Sinead, Wong, Sonny, Székely, Tamás and Harrison, Freya (2013) Selflessness is sexy : reported helping behaviour increases desirability of men and women as long-term sexual partners. BMC Evolutionary Biology, 13 (1). 182. doi:10.1186/1471-2148-13-182 ISSN 1471-2148.

Harrison, Freya (2013) Bacterial cooperation in the wild and in the clinic : are pathogen social behaviours relevant outside the laboratory? BioEssays, 35 (2). pp. 108-112. doi:10.1002/bies.201200154 ISSN 0265-9247.

Harrison, Freya (2013) Dynamic social behaviour in a bacterium : pseudomonas aeruginosapartially compensates for siderophore loss to cheats. Journal of Evolutionary Biology, 26 (6). pp. 1370-1378. doi:10.1111/jeb.12126 ISSN 1010-061X.

2012

Harrison, Freya (2012) Bacterial cooperation in the wild and in the clinic : are pathogen social behaviours relevant outside the laboratory? BioEssays, 35 (2). pp. 108-112. doi:10.1002/bies.201200154 ISSN 0265-9247.

Scanlan, Pauline D., Buckling, Angus, Kong, Weidong, Wild, Yvette, Lynch, Susan V. and Harrison, Freya (2012) Gut dysbiosis in cystic fibrosis. Journal of Cystic Fibrosis, 11 (5). pp. 454-455. doi:10.1016/j.jcf.2012.03.007 ISSN 1569-1993.

2011

Harrison, Freya and Buckling, Angus (2011) Wider access to genotypic space facilitates loss of cooperation in a bacterial mutator. PLoS One, 6 (2). e17254. doi:10.1371/journal.pone.0017254 ISSN 1932-6203.

Harrison, Freya and El Mouden, Claire (2011) Exploring the effects of working for endowments on behaviour in standard economic games. PLoS One, 6 (11). e27623. doi:10.1371/journal.pone.0027623 ISSN 1932-6203.

Harrison, Freya, Sciberras, James and James, Richard (2011) Strength of social tie predicts cooperative investment in a human social network. PLoS One, 6 (3). e18338. doi:10.1371/journal.pone.0018338 ISSN 1932-6203.

2010

Harrison, Freya (2010) Getting started with meta-analysis. Methods in Ecology and Evolution, 2 (1). pp. 1-10. doi:10.1111/j.2041-210X.2010.00056.x ISSN 2041-210X.

Racey, Daniel, Inglis, Robert Fredrik, Harrison, Freya, Oliver, Antonio and Buckling, Angus (2010) The effect of elevated mutation rates on the evolution of cooperation and virulence of pseudomonas aeruginosa. Evolution, 64 (2). pp. 515-521. doi:10.1111/j.1558-5646.2009.00821.x ISSN 0014-3820.

2009

Harrison, Freya, Barta, Zoltán, Cuthill, Innes C. and Székely, Tamás (2009) How is sexual conflict over parental care resolved? A meta-analysis. Journal of Evolutionary Biology, 22 (9). pp. 1800-1812. doi:10.1111/j.1420-9101.2009.01792.x ISSN 1010-061X.

Harrison, Freya and Buckling, Angus (2009) Siderophore production and biofilm formation as linked social traits. The ISME Journal, 3 (5). pp. 632-634. doi:10.1038/ismej.2009.9 ISSN 1751-7362.

Kummerli, R., Griffin, A. S., West, S. A., Buckling, A. and Harrison, Freya (2009) Viscous medium promotes cooperation in the pathogenic bacterium Pseudomonas aeruginosa. Proceedings of the Royal Society B: Biological Sciences, 276 (1672). pp. 3531-3538. doi:10.1098/rspb.2009.0861 ISSN 0962-8452.

2008

Harrison, Freya, Paul, Jon, Massey, Ruth C. and Buckling, Angus (2008) Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa. The ISME Journal, 2 (1). pp. 49-55. doi:10.1038/ismej.2007.96 ISSN 1751-7362.

2007

Buckling, Angus, Harrison, Freya, Vos, Michiel, Brockhurst, Michael A., Gardner, Andy, West, Stuart A. and Griffin, Ashleigh (2007) Siderophore-mediated cooperation and virulence in Pseudomonas aeruginosa. FEMS Microbiology Ecology, 62 (2). pp. 135-141. doi:10.1111/j.1574-6941.2007.00388.x ISSN 0168-6496.

Harrison, Freya and Buckling, A. (2007) High relatedness selects against hypermutability in bacterial metapopulations. Proceedings of the Royal Society B: Biological Sciences, 274 (1615). pp. 1341-1347. doi:10.1098/rspb.2006.0408 ISSN 0962-8452.

Harrison, Freya (2007) Microbial ecology of the cystic fibrosis lung. Microbiology, 153 (4). pp. 917-923. doi:10.1099/mic.0.2006/004077-0 ISSN 1350-0872.

2006

Harrison, Freya, Browning, Lucy E., Vos, Michiel and Buckling, Angus (2006) Cooperation and virulence in acute Pseudomonas aeruginosainfections. BMC Biology, 4 (1). 21. doi:10.1186/1741-7007-4-21 ISSN 1741-7007.

2005

Harrison, Freya and Buckling, Angus (2005) Hypermutability impedes cooperation in pathogenic bacteria. Current Biology, 15 (21). pp. 1968-1971. doi:10.1016/j.cub.2005.09.048 ISSN 0960-9822.