Journal Article

Carpenter, Byron (2018) Current applications of mini G proteins to study the structure and function of G protein-coupled receptors. AIMS Bioengineering, 5 (4). pp. 209-225. doi:10.3934/bioeng.2018.4.209

Tsai, Ching-Ju, Pamula, Filip, Nehmé, Rony, Mühle, Jonas, Weinert, Tobias, Flock, Tilman, Nogly, Przemyslaw, Edwards, Patricia C., Carpenter, Byron, Gruhl, Thomas, Ma, Pikyee, Deupi, Xavier, Standfuss, Jörg, Tate, Christopher G. and Schertler, Gebhard F. X. (2018) Crystal structure of rhodopsin in complex with a mini-G_o sheds light on the principles of G protein selectivity. Science Advances, 4 (9). eaat7052. doi:10.1126/sciadv.aat7052

Yen, Hsin-Yung, Hoi, Kin Kuan, Liko, Idlir, Hedger, George, Horrell, Michael R., Song, Wanling, Wu, Di, Heine, Philipp, Warne, Tony, Lee, Yang, Carpenter, Byron, Plückthun, Andreas, Tate, Christopher G., Sansom, Mark S. P. and Robinson, Carol V. (2018) PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling. Nature, 559 (7714). pp. 423-427. doi:10.1038/s41586-018-0325-6

Wan, Qingwen, Okashah, Najeah, Inoue, Asuka, Nehmé, Rony, Carpenter, Byron, Tate, Christopher G. and Lambert, Nevin A. (2018) Mini G protein probes for active G protein– coupled receptors (GPCRs) in live cells. Journal of Biological Chemistry, 293 . pp. 7466-7473. doi:10.1074/jbc.RA118.001975

García-Nafría, Javier, Lee, Yang, Bai, Xiaochen, Carpenter, Byron and Tate, Christopher G. (2018) Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein. eLife, 2018 (7). e35946. doi:10.7554/eLife.35946

Carpenter, Byron and Lebon, Guillaume (2017) Human adenosine A2A receptor : molecular mechanism of ligand binding and activation. Frontiers in Pharmacology, 8 . 898. doi:10.3389/fphar.2017.00898

Carpenter, Byron and Tate, Christopher G. (2017) Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. Current Opinion in Structural Biology, 45 . pp. 124-132. doi:10.1016/j.sbi.2017.04.010

Carpenter, Byron and Tate, Christopher G. (2017) Expression and purification of mini G proteins from Escherichia coli. Bio-protocol, 7 (8). e2235.

Carpenter, Byron and Tate, Christopher G. (2017) Expression, purification and crystallisation of the adenosine A2A receptor bound to an engineered Mini G protein. Bio-protocol, 7 (8). e2234.

Nehmé, Rony, Carpenter, Byron, Singhal, Ankita, Strege, Annette, Edwards, Patricia C., White, Courtney F., Du, Haijuan, Grisshammer, Reinhard and Tate, Christopher G. (2017) Mini-G proteins : novel tools for studying GPCRs in their active conformation. PLoS One, 12 (4). e0175642. doi:10.1371/journal.pone.0175642

Carpenter, Byron and Tate, Christopher G. (2016) Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation. Protein Engineering Design and Selection, 29 (12). pp. 583-594. doi:10.1093/protein/gzw049

Carpenter, Byron, Nehmé, Rony, Warne, Tony, Leslie, Andrew G. W. and Tate, Christopher G. (2016) Structure of the adenosine A2A receptor bound to an engineered G protein. Nature, 536 (7614). pp. 104-107. doi:10.1038/nature18966

Carpenter, Byron, Hemsworth, Glyn R., Wu, Zida, Maamra, Mabrouka, Strasburger, Christian J., Ross, Richard J. and Artymiuk, Peter J. (2012) Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20 (3). pp. 487-497. doi:10.1016/j.str.2012.01.019

Miguel, R. N., Chen, S., Nikfarjam, L., Kominami, S., Carpenter, Byron, Dal Pra, C., Betterle, C., Zanchetta, R., Nakamatsu , T., Powell, M., Hewer, R., Blundell , T. L., Smith, B. R. and Furmaniak, J. (2005) Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling. European Journal of Endocrinology, 153 (6). pp. 949-961. doi:10.1530/eje.1.02044

Book Item

Strege, Annette, Carpenter, Byron, Edwards, Patricia C. and Tate, Christopher G. (2017) Strategy for the thermostabilization of an agonist-bound GPCR coupled to a G protein. In: Ziegler, Christine, (ed.) Methods In Enzymology. A Structure-Function Toolbox for Membrane Transporter and Channels, 594 . Elsevier, pp. 243-264. ISBN 9780128123539 (In Press)