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Number of items: 135.
Journal Article
Whitley, Kevin D., Grimshaw, James, Roberts, David M., Karinou, Eleni, Stansfeld, Phillip J. and Holden, SΓ©amus (2024) Peptidoglycan synthesis drives a single population of septal cell wall synthases during division in Bacillus subtilis. Nature Microbiology . doi:10.1038/s41564-024-01650-9 ISSN 2058-5276. (In Press)
Marmont, Lindsey S., Orta, Anna K., Baileeves, Becca W. A., Sychantha, David, FernΓ‘ndez-Galliano, Ana, Li, Yancheng E., Greene, Neil G., Corey, Robin A., Stansfeld, Phillip J., Clemons, William M. and Bernhardt, Thomas G. (2024) Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa. Nature Microbiology, 9 (3). pp. 763-775. doi:10.1038/s41564-024-01603-2 ISSN 2058-5276.
Whitley, Kevin D., Grimshaw, James, Roberts, David M., Karinou, Eleni, Stansfeld, Phillip J. and Holden, SΓ©amus (2024) A one-track model for spatiotemporal coordination of Bacillus subtilis septal 2 cell wall synthesis. Nature Microbiology . ISSN 2058-5276. (In Press)
BoΜhning, Jan, Graham, Miles, Letham, Suzanne C., Davis, Luke K., Schulze, Ulrike, Stansfeld, Phillip J., Corey, Robin A., Pearce, Philip , Tarafder, Abul K. and Bharat, Tanmay A. M. (2023) Biophysical basis of filamentous phage tactoid-mediated antibiotic tolerance in P. aeruginosa. Nature Communications, 14 . 8429. doi:10.1038/s41467-023-44160-8 ISSN 2041-1723.
Ansell, T. Bertie, Song, Wanling, Coupland, Claire E., Carrique, LoΓ―c, Corey, Robin A., Duncan, Anna L., Cassidy, C. Keith, Geurts, Maxwell M. G., Rasmussen, Tim, Ward, Andrew B., Siebold, Christian, Stansfeld, Phillip J. and Sansom, Mark S. P. (2023) LipIDens : simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins. Nature Communications, 14 (1). 7774. doi:10.1038/s41467-023-43392-y ISSN 2041-1723.
Yang, Yiying, Chen, Haoxiang, Corey, Robin A., Morales, Violette, Quentin, Yves, Froment, Carine, Caumont-Sarcos, Anne, Albenne, CΓ©cile, Burlet-Schiltz, Odile, Ranava, David, Stansfeld, Phillip J., Marcoux, Julien and Ieva, Raffaele (2023) LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry. Nature Communications, 14 (1). 6368. doi:10.1038/s41467-023-42007-w ISSN 2041-1723.
Cassidy, C. Keith, Qin, Zhuan, Frosio, Thomas, Gosink, Khoosheh, Yang, Zhengyi, Sansom, Mark S. P., Stansfeld, Phillip J., Parkinson, John S. and Zhang, Peijun (2023) Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells. mBio, 14 (5). e00793-23. doi:10.1128/mbio.00793-23 ISSN 2150-7511.
Nygaard, Rie, Graham, Chris L. B., Belcher Dufrisne, Meagan, Colburn, Jonathan D., Pepe, Joseph, Hydorn, Molly A., Corradi, Silvia, Brown, Chelsea M., Ashraf, Khuram U., Vickery, Owen N. et al.
(2023)
Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex.
Nature Communications, 14
(1).
5151.
doi:10.1038/s41467-023-40483-8
ISSN 2041-1723.
Xu, Dijin, Jiang, Weiqian, Wu, Lizhen, Gaudet, Ryan G., Park, Eui-Soon, Su, Maohan, Cheppali, Sudheer Kumar, Cheemarla, Nagarjuna R., Kumar, Pradeep, Uchil, Pradeep D., Grover, Jonathan R., Foxman, Ellen F., Brown, Chelsea M., Stansfeld, Phillip J., Bewersdorf, Joerg, Mothes, Walther, Karatekin, Erdem, Wilen, Craig B. and MacMicking, John D. (2023) PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection. Nature, 619 . pp. 819-827. doi:10.1038/s41586-023-06322-y ISSN 0028-0836.
Fuss, Michael F., Wieferig, Jan-Philip, Corey, Robin A., Hellmich, Yvonne, TascΓ³n, Igor, Sousa, Joana S., Stansfeld, Phillip J., Vonck, Janet and HΓ€nelt, Inga (2023) Cyclic di-AMP traps proton-coupled K + transporters of the KUP family in an inward-occluded conformation. Nature Communications, 14 (1). 3683. doi:10.1038/s41467-023-38944-1 ISSN 2041-1723.
Cook, Jonathan P., Baverstock, Tyler C., McAndrew, Martin B. L., Roper, David I., Stansfeld, Phillip J. and Crow, Allister (2023) Activator-induced conformational changes regulate division-associated peptidoglycan amidases. Proceedings of the National Academy of Sciences of the United States of America, 120 (24). e2302580120. doi:10.1073/pnas.2302580120 ISSN 0027-8424.
Couves, Emma C., Gardner, Scott, Voisin, Tomas B., Bickel, Jasmine K., Stansfeld, Phillip J., Tate, Edward W. and Bubeck, Doryen (2023) Structural basis for membrane attack complex inhibition by CD59. Nature Communications, 14 (1). 890. doi:10.1038/s41467-023-36441-z ISSN 2041-1723.
Severi, Emmanuele, Batista, Mariana R. B., Lannoy, Adelie, Stansfeld, Phillip J. and Palmer, Tracy (2023) Characterization of a TatA/TatB binding site on the TatC component of the Escherichia coli twin arginine translocase. Microbiology, 169 (2). 001298. doi:10.1099/mic.0.001298 ISSN 1465-2080.
Brown, Chelsea M., Corey, Robin A., GrΓ©lard, Axelle , Gao, Ya, Kyo Choi, Yeol, Luna, Emanuel, Gilleron, Martine, Destainville, Nicolas, Nigou, JΓ©rΓ΄me, Loquet, Antoine, Fullam, Elizabeth, Im, Wonpil, Stansfeld, Phillip J. and Chavent, Matthieu (2023) Supramolecular organisation and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane. Proceedings of the National Academy of Sciences of the United States of America, 120 (5). e2212755120. doi:10.1073/pnas.2212755120 ISSN 0027-8424.
Marmont, Lindsey S., Orta, Anna K., Baileeves, Becca W. A., Sychantha, David, FernΓ‘ndez-Galliano, Ana, Li, Yancheng E., Greene, Neil G., Corey, Robin A., Stansfeld, Phillip J., Clemons Jr., William M. and Bernhardt , Thomas G. (2023) A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall. Nature microbiology . ISSN 2058-5276. (In Press)
Corey, Robin A., Harrison, Noah, Stansfeld, Phillip J., Sansom, Mark S. P. and Duncan, Anna L. (2022) Cardiolipin, and not monolysocardiolipin, preferentially binds to the interface of complexes III and IV. Chemical Science, 13 (45). pp. 13489-13498. doi:10.1039/d2sc04072g ISSN 2041-6520.
Ouyang, Ruochen, Costa, Ana Rita, Cassidy, C. Keith, Otwinowska, Aleksandra, Williams, Vera C. J., Latka, Agnieszka, Stansfeld, Phillip J., Drulis-Kawa, Zuzanna, Briers, Yves, Pelt, DaniΓ«l M., Brouns, Stan J. J. and Briegel, Ariane (2022) High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers. Nature Communications, 13 (1). 7241. doi:10.1038/s41467-022-34972-5 ISSN 2041-1723.
Silberberg, Jakob M., Stock, Charlott, Hielkema, Lisa, Corey, Robin A., Rheinberger, Jan, Wunnicke, Dorith, Dubach, Victor R. A., Stansfeld, Phillip J., HΓ€nelt, Inga and Paulino, Cristina (2022) Inhibited KdpFABC transitions into an E1 off-cycle state. eLife, 11 . doi:10.7554/elife.80988 ISSN 2050-084X.
Pipatpolkai, Tanadet, Usher, Samuel G., Vedovato, Natascia, Ashcroft, Frances M. and Stansfeld, Phillip J. (2022) The dynamic interplay of PIP 2 and ATP in the regulation of the K ATP channel. The Journal of Physiology, 600 (20). pp. 4503-4519. doi:10.1113/JP283345 ISSN 0022-3751.
Radhakrishnan, Anjana, Brown, Chelsea M., Guy, Collette S., Cooper, Charlotte, Pacheco-GΓ³mez, RaΓΊl, Stansfeld, Phillip J. and Fullam, Elizabeth (2022) Interrogation of the pathogen box reveals small molecule ligands against the mycobacterial trehalose transporter LpqY-SugABC. RSC Medicinal Chemistry, 13 (10). pp. 1225-1233. doi:10.1039/D2MD00104G ISSN 2632-8682.
Renne, Mike, Corey, Robin, VerΓssimo Ferreira, Joana, Stansfeld, Phillip J. and Carvalho, Pedro (2022) Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters. Journal of Cell Biology, 221 (9). e202112068. doi:10.1083/jcb.202112068 ISSN 0021-9525.
Williams, Sophie I, Yu, Xiulian, Ni, Tao, Gilbert, Robert J C and Stansfeld, Phillip J. (2022) Structural, functional and computational studies of membrane recognition by Plasmodium Perforin-Like Proteins 1 and 2. Journal of molecular biology, 434 (13). 167642. doi:10.1016/j.jmb.2022.167642 ISSN 1089-8638.
Caldwell, Tracy A., Vickery, Owen N., Colburn, Jonathan David, Stansfeld, Phillip J. and Columbus, Linda (2022) Conformational dynamics of the membrane enzyme LspA upon antibiotic and substrate binding. Biophysical Journal, 121 (11). pp. 2078-2083. doi:10.1016/j.bpj.2022.04.038 ISSN 0006-3495.
Oluwole, Abraham O., Corey, Robin A., Brown, Chelsea M., HernΓ‘ndez-Rocamora, Victor M., Stansfeld, Phillip J., Vollmer, Waldemar, Bolla, Jani R. and Robinson, Carol V. (2022) Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients. Nature Communications, 13 (1). 2278. doi:10.1038/s41467-022-29836-x ISSN 2041-1723.
Ashraf, Khuram U., Nygaard, Rie, Vickery, Owen N., Erramilli, Satchal K., Herrera, Carmen M., McConville, Thomas H., Petrou, Vasileios I., Giacometti, Sabrina I., Belcher Dufrisne, Meagan, Nosol, Kamil et al.
(2022)
Structural basis of lipopolysaccharide maturation by the WaaL O-antigen ligase.
Nature, 604
.
pp. 371-376.
doi:10.1038/s41586-022-04555-x
ISSN 0028-0836.
Maloney, Finn P., Kuklewicz, Jeremi, Corey, Robin A., Bi, Yunchen, Ho, Ruoya, Mateusiak, Lukasz, Pardon, Els, Steyaert, Jan, Stansfeld, Phillip J. and Zimmer, Jochen (2022) Structure, substrate-recognition, and initiation of hyaluronan synthase. Nature, 604 . pp. 195-201. doi:10.1038/s41586-022-04534-2 ISSN 0028-0836.
Song, Wanling, Corey, Robin, Ansell, Tillson, Cassidy, C. Keith, Horrell, Michael, Duncan, Anna, Stansfeld, Phillip J. and Sansom, Mark S. P. (2022) PyLipID : A Python package for analysis of protein-lipid interactions from MD simulations. Journal of Chemical Theory and Computation, 18 (2). pp. 1188-1201. doi:10.1021/acs.jctc.1c00708 ISSN 1549-9618.
Herdman, M., von KuΜgelgen, A., Kureisaite-Ciziene, D., Duman, R., El Omari, K., Garman, E. F., Kjaer, A., Kolokouris, D., LoΜwe, J., Wagner, A., Stansfeld, Phillip J. and Bharat, T. (2022) High-resolution mapping of metal ions reveals principles of surface layer assembly in Caulobacter crescentus cells. Structure, 30 (2). pp. 215-228. doi:10.1016/j.str.2021.10.012 ISSN 0969-2126.
Quetschlich, Daniel, Esser, Tim K., Newport, Thomas D., Fiorentino, Francesco, Shutin, Denis, Chen, Siyun, Davis, Rachel, Lovera, Silvia, Liko, Idlir, Stansfeld, Phillip J., Robinson, Carol V. and Martelli, Pier Luigi (2021) NaViA : a program for the visual analysis of complex mass spectra. Bioinformatics, 37 (24). pp. 4876-4878. doi:10.1093/bioinformatics/btab436 ISSN 1367-4803.
Vickery, Owen N. and Stansfeld, Phillip J. (2021) CG2AT2 : an enhanced fragment-based approach for serial multi-scale molecular dynamics simulations. Journal of Chemical Theory and Computation, 17 (10). pp. 6472-6482. doi:10.1021/acs.jctc.1c00295 ISSN 1549-9618.
Ansell, T. Bertie, Curran, Luke, Horrell, Michael R., Pipatpolkai, Tanadet, Letham, Suzanne C., Song, Wanling, Siebold, Christian, Stansfeld, Phillip J., Sansom, Mark S. P. and Corey, Robin A. (2021) Relative affinities of proteinβcholesterol interactions from equilibrium molecular dynamics simulations. Journal of Chemical Theory and Computation, 17 (10). pp. 6548-6558. doi:10.1021/acs.jctc.1c00547 ISSN 1549-9626.
Klug, Yoel A., Deme, Justin C., Corey, Robin A., Renne, Mike F., Stansfeld, Phillip J., Lea, Susan M. and Caralho, Pedro (2021) Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex. Nature Communications, 12 . 5892. doi:10.1038/s41467-021-26162-6 ISSN 2041-1723.
Silberberg, Jakob M., Corey, Robin A., Hielkema, Lisa, Stock, Charlott, Stansfeld, Phillip J., Paulino, Cristina and HΓ€nelt, Inga (2021) Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC. Nature Communications, 12 (1). 5098. doi:10.1038/s41467-021-25242-x ISSN 2041-1723.
Dinsdale, Ria L., Pipatpolkai, Tanadet, Agostinelli, Emilio, Russell, Angela J., Stansfeld, Phillip J. and Tammaro, Paolo (2021) An outer-pore gate modulates the pharmacology of the TMEM16A channel. Proceedings of the National Academy of Sciences of the United States of America, 118 (34). e2023572118. doi:10.1073/pnas.2023572118 ISSN 0027-8424.
Corey, Robin A., Song, Wanling, Duncan, Anna L., Ansell, T. Bertie, Sansom, Mark S. P. and Stansfeld, Phillip J. (2021) Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins. Science Advances, 7 (34). eabh2217. doi:10.1126/sciadv.abh2217 ISSN 2375-2548.
Perkins, Arden, Tudorica, Dan A., Teixeira, Raphael D., Schirmer, Tilman, Zumwalt, Lindsay, Ogba, O. Maduka, Cassidy, C. Keith, Stansfeld, Phillip J., Guillemin, Karen and Cooper, Vaughn S. (2021) A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation. mBio, 12 (3). e00173-21. doi:10.1128/mBio.00173-21 ISSN 2150-7511.
Pipatpolkai, Tanadet, Quetschlich, Daniel and Stansfeld, Phillip J. (2021) From bench to biomolecular simulation : phospholipid modulation of potassium channels. Journal of Molecular Biology . 167105. doi:10.1016/j.jmb.2021.167105 ISSN 0022-2836.
Hammond, Katharine, Cipcigan, Flaviu, Al Nahas, Kareem, Losasso, Valeria, Lewis, Helen, Cama, Jehangir, Martelli, Fausto, Simcock, Patrick W., Fletcher, Marcus, Ravi, Jascindra, Stansfeld, Phillip J., Pagliara, Stefano, Hoogenboom, Bart W., Keyser, Ulrich F., Sansom, Mark S. P., Crain, Jason and Ryadnov, Maxim G. (2021) Switching cytolytic nanopores into antimicrobial fractal ruptures by a single side chain mutation. ACS Nano, 15 (6). pp. 9679-9689. doi:10.1021/acsnano.1c00218 ISSN 1936-0851.
Moseng, Mitchell A., Lyu, Meinan, Pipatpolkai, Tanadet, Glaza, Przemyslaw, Emerson, Corey C., Stewart, Phoebe L., Stansfeld, Phillip J. and Yu, Edward W. (2021) Cryo-EM structures of CusA reveal a mechanism of metal-ion export. mBio, 12 (2). e00452-21. doi:10.1128/mBio.00452-21 ISSN 2150-7511.
Burt, Alister, Cassidy, C. Keith, Stansfeld, Phillip J. and Gutsche, Irina (2021) Alternative architecture of the E. coli chemosensory array. Biomolecules, 11 (4). e495. doi:10.3390/biom11040495 ISSN 2218-273X.
Simcock, Patrick W., Bublitz, Maike, Cipcigan, Flaviu, Ryadnov, Maxim G., Crain, Jason, Stansfeld, Phillip J. and Sansom, Mark S. P. (2021) Membrane binding of antimicrobial peptides is modulated by lipid charge modification. Journal of Chemical Theory and Computation, 17 (2). pp. 1218-1228. doi:10.1021/acs.jctc.0c01025 ISSN 1549-9618.
Furze, Christopher M., Delso, Ignacio, Casal, Enriqueta, Guy, Collette S., Seddon, Chloe, Brown, Chelsea M., Parker, Hadyn L., Radhakrishnan, Anjana, Pacheco-Gomez, Raul, Stansfeld, Phillip J., Angulo, Jesus, Cameron, Alexander D. and Fullam, Elizabeth (2021) Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter. Journal of Biological Chemistry, 296 . 100307. doi:10.1016/j.jbc.2021.100307 ISSN 0021-9258.
Deme, Justin C., Johnson, Steven, Vickery, Owen N., Muellbauer, Amy, Monkhouse, Holly, Griffiths, Thomas, Hennell James, Rory, Berks, Ben C., Coulton, James W., Stansfeld, Phillip J. and Lea, Susan M. (2020) Structures of the stator complex that drives rotation of the bacterial flagellum. Nature microbiology, 5 . pp. 1553-1564. doi:10.1038/s41564-020-0788-8 ISSN 2058-5276.
Baker, Alexander, Richards, Sarah-Jane, Guy, Collette S., Congdon, Thomas R., Hasan, Muhammad, Zwetsloot, Alexander J., Gallo, Angelo, Lewandowski, JΓ³zef R., Stansfeld, Phillip J., Straube, Anne, Walker, Marc, Chessa, Simona, Pergolizzi, Giulia, Dedola, Simone, Field, Robert A. and Gibson, Matthew I. (2020) The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device. ACS Central Science, 6 (11). pp. 2046-2052. doi:10.1021/acscentsci.0c00855 ISSN 2374-7951.
Fiorentino, Francesco, Sauer, Joshua B., Qiu, XingYu, Corey, Robin A., Cassidy, Keith, Mynors-Wallis, Benjamin, Mehmood, Shahid, Bolla, Jani R., Stansfeld, Phillip J. and Robinson, Carol V. (2020) Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide. Nature Chemical Biology, 17 . pp. 187-195. doi:10.1038/s41589-020-00694-2 ISSN 1552-4450.
Cook, Jonathan P., Baverstock, Tyler, McAndrew, Martin B. L., Stansfeld, Phillip J., Roper, David I. and Crow, Allister (2020) Insights into intrinsic resistance and bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain. Proceedings of the National Academy of Sciences of the United States of America, 117 (45). pp. 28355-28365. doi:10.1073/pnas.2017134117 ISSN 0027-8424.
Pipatpolkai, Tanadet , Corey, Robin A., Proks, Peter , Ashcroft, Frances M. and Stansfeld, Phillip J. (2020) Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease. Communications chemistry, 3 . 147. doi:10.1038/s42004-020-00391-0 ISSN 2399-3669.
Stansfeld, Phillip J. (2020) Greasing the gears of mechanosensitive piezo channels with phosphoinositides and cholesterol. Biophysical Journal, 119 (8). pp. 1467-1469. doi:10.1016/j.bpj.2020.08.030 ISSN 0006-3495.
Tohidifar, Payman , Bodhankar,, Girija , Pei, Sichong, Cassidy, C. Keith, Walukiewicz, Hanna , Orodal, George , Stansfeld, Phillip J. and Rao, Christopher (2020) The unconventional cytoplasmic sensing mechanism for ethanol chemotaxis in Bacillus subtilis. mBio, 11 . e02177-20. doi:10.1128/mBio.02177-20 ISSN 2150-7511.
Pipatpolkai, Tanadet, Usher, Samuel, Stansfeld, Phillip J. and Ashcroft, Frances M. (2020) New insights into KATP channel gene mutations and neonatal diabetes mellitus. Nature Reviews Endocrinology, 16 (7). pp. 378-393. doi:10.1038/s41574-020-0351-y ISSN 1759-5029.
DomaΕski, Jan, Sansom, Mark S. P., Stansfeld, Phillip J. and Best, Robert B. (2020) Atomistic mechanism of transmembrane helix association. PLOS Computational Biology, 16 (6). e1007919. doi:10.1371/journal.pcbi.1007919 ISSN 1553-7358.
Palmer, Tracy and Stansfeld, Phillip J. (2020) Targeting of proteins to the twin-arginine transport pathway. Molecular Microbiology, 113 (5). pp. 861-871. doi:10.1111/mmi.14461 ISSN 0950-382X.
Rao, Shanlin, Bates, George T., Matthews, Callum R., Newport, Thomas D., Vickery, Owen N. and Stansfeld, Phillip J. (2020) Characterising membrane association and periplasmic transfer of bacterial lipoproteins through molecular dynamics simulations. Structure, 28 (4). pp. 475-487. doi:10.1016/j.str.2020.01.012 ISSN 0969-2126.
Bolla, Jani Reddy, Corey, Robin A., Sahin, Cagla, Gault, Joseph, Hummer, Alissa, Hopper, Jonathan T. S., Lane, David P., Drew, David, Allison, Timothy M., Stansfeld, Phillip J., Robinson, Carol V. and Landreh, Michael (2020) A mass spectrometry-based approach to distinguish annular and specific lipid binding to membrane proteins. Angewandte Chemie International Edition, 59 (9). pp. 3523-3528. doi:10.1002/anie.201914411 ISSN 1433-7851.
Yamamoto, Eiji, DomaΕski,, Jan, Naughton, Fiona B., Best , Robert B., Kalli, Antreas C., Stansfeld, Phillip J. and Sansom, Mark S. P. (2020) Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes. Science Advances, 6 (8). eaay5736. doi:10.1126/sciadv.aay5736 ISSN 2375-2548.
Burt, Alister, Cassidy, C. Keith, Ames, Peter, Bacia-Verloop, Maria, Baulard, Megghane, Huard, Karine, Luthey-Schulten, Zaida, Desfosses, Ambroise, Stansfeld, Phillip J., Margolin, William, Parkinson, John S. and Gutsche, Irina (2020) Complete structure of the chemosensory array core signalling unit in an E. coli 1 minicell strain. Nature Communications, 11 . 743. doi:10.1038/s41467-020-14350-9 ISSN 2041-1723.
Corey, Robin A., Stansfeld, Phillip J. and Sansom, Mark S. P. (2020) The energetics of protein-lipid interactions as viewed by molecular simulations. Biochemical Society Transactions, 48 (1). pp. 25-37. doi:10.1042/BST20190149 ISSN 0300-5127.
TascΓ³n, Igor, Sousa, Joana S., Corey, Robin A., Mills, Deryck J., Griwatz, David, AumΓΌller, Nadine, Mikusevic, Vedrana, Stansfeld, Phillip J., Vonck, Janet and HΓ€nelt, Inga (2020) Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications, 11 (1). 626. doi:10.1038/s41467-020-14441-7 ISSN 2041-1723.
Ni, Tao, Jiao, Fang, Yu, Xiulian, Aden, SaΕ‘a, Ginger, Lucy, Williams, Sophie, Bai, Fangfang, PraΕΎΓ‘k, VojtΔch, Karia, Dimple, Stansfeld, Phillip J., Zhang, Peijun, Munson, George, Anderluh, Gregor, Scheuring, Simon and Gilbert, Robert J. C. (2020) Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Science Advances, 6 (5). eaax8286. doi:10.1126/sciadv.aax8286 ISSN 2375-2548.
von KΓΌgelgen, Andriko, Tang, Haiping, Hardy, Gail G., Kureisaite-Ciziene, Danguole, Brun, Yves V., Stansfeld, Phillip J., Robinson, Carol V. and Bharat, Tanmay A. M. (2020) In situ structure of an intact lipopolysaccharide-bound bacterial surface layer. Cell, 180 (2). P348-358.E15. doi:10.1016/j.cell.2019.12.006 ISSN 0092-8674.
Cassidy, Keith, Himes, Benjamin A., Sun, Dapeng, Ma, Jun, Zhao, Gongpu, Parkinson, John S., Stansfeld, Phillip J., Luthey-Schulten, Z. and Zhang, Peijun (2020) Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations. Communications Biology, 3 (24). doi:10.1038/s42003-019-0748-0 ISSN 2399-3642.
Pye, Valerie E., Rosa, Annachiara, Bertelli, Cinzia, Struwe, Weston B., Maslen, Sarah L., Corey, Robin A., Liko, Idlir, Hassall, Mark, Mattiuzzo, Giada, Ballandras-Colas, Allison, Nans, Andrea, Takeuchi, Yasuhiro, Stansfeld, Phillip J., Skehel, J. Mark, Robinson, Carol V., Pizzato, Massimo and Cherepanov, Peter (2020) A bipartite structural organization defines the SERINC family of HIV-1 restriction factors. Nature Structural & Molecular Biology, 27 . pp. 78-83. doi:10.1038/s41594-019-0357-0 ISSN 1545-9993.
Dijkman, Patricia M., MuΓ±oz-GarcΓa, Juan C., Steven R., Lavington, Suemy Kumagai, Patricia , dos Reis, Rosana I., Yin, Daniel , Stansfeld, Phillip J., Costa-Filho, Antonio JosΓ© and Watt , Anthony (2020) Conformational dynamics of a G protein-coupled receptor helix 8 in lipid membranes. Science Advances, 6 (33). eaav8207. doi:10.1126/sciadv.aav8207 ISSN 2375-2548.
Abraham, Mark, Apostolov, Rossen, Barnoud, Jonathan, Bauer, Paul, Blau, Christian, Bonvin, Alexandre M.J.J., Chavent, Matthieu, Chodera, John, ΔondiΔ-JurkiΔ, Karmen, Delemotte, Lucie et al.
(2019)
Sharing data from molecular simulations.
Journal of Chemical Information and Modeling, 59
(10).
pp. 4093-4099.
doi:10.1021/acs.jcim.9b00665
ISSN 1549-9596.
Parker, Joanne L., Corey, Robin A., Stansfeld, Phillip J. and Newstead, Simon (2019) Structural basis for substrate speciο¬city and regulation of nucleotide sugar transporters in the lipid bilayer. Nature Communications, 10 . 4657. doi:10.1038/S41467-019-12673-w ISSN 2041-1723.
Corey, Robin A., Vickery, Owen N., Sansom, Mark S. P. and Stansfeld, Phillip J. (2019) Insights into membrane proteinβlipid interactions from free energy calculations. Journal of Chemical Theory and Computation, 15 (10). pp. 5727-5736. doi:10.1021/acs.jctc.9b00548 ISSN 1549-9618.
Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A. et al.
(2019)
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nature Communications, 10
(1).
3956 .
doi:10.1038/s41467-019-11753-1
ISSN 2041-1723.
RinnΓ©, Susanne, Kiper, Aytug K., Vowinkel, Kirsty S., RamΓrez, David, Schewe, Marcus, Bedoya, Mauricio, Aser, Diana, Gensler, Isabella, Netter, Michael F., Stansfeld, Phillip J., Baukrowitz, Thomas, Gonzalez, Wendy and Decher, Niels (2019) The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels. eLife, 8 . doi:10.7554/eLife.39476 ISSN 2050-084X.
Caffalette, Christopher A., Corey, Robin A., Sansom, Mark S. P., Stansfeld, Phillip J. and Zimmer, Jochen (2019) A lipid gating mechanism for the channel-forming O antigen ABC transporter. Nature Communications, 10 (1). 824. doi:10.1038/s41467-019-08646-8 ISSN 2041-1723.
Rao, Shanlin, Klesse, Gianni, Stansfeld, Phillip J., Tucker, Stephen J. and Sansom, Mark S. P. (2019) A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates. Proceedings of the National Academy of Sciences of the United States of America, 116 (28). pp. 13989-13995. doi:10.1073/pnas.1902702116 ISSN 0027-8424.
Autzen, Henriette E., KoldsΓΈ, Heidi, Stansfeld, Phillip J., Gourdon, Pontus, Sansom, Mark S. P. and Nissen, Poul (2018) Interactions of a bacterial Cu(I)-ATPase with a complex lipid environment. Biochemistry, 57 (28). pp. 4063-4073. doi:10.1021/acs.biochem.8b00326 ISSN 0006-2960.
Chavent, Matthieu, Karia, Dimple, Kalli, Antreas C., DomaΕski, Jan, Duncan, Anna L., Hedger, George, Stansfeld, Phillip J., Seiradake, Elena, Jones, E. Yvonne and Sansom, Mark S. P. (2018) Interactions of the EphA2 kinase domain with PIPs in membranes : implications for receptor function. Structure, 26 (7). 1025-1034.e2. doi:10.1016/j.str.2018.05.003 ISSN 0969-2126.
Liko, Idlir, Degiacomi, Matteo T., Lee, Sejeong, Newport, Thomas D., Gault, Joseph, Reading, Eamonn, Hopper, Jonathan T. S., Housden, Nicholas G., White, Paul, Colledge, Matthew, Sula, Altin, Wallace, B. A., Kleanthous, Colin, Stansfeld, Phillip J., Bayley, Hagan, Benesch, Justin L. P., Allison, Timothy M. and Robinson, Carol V. (2018) Lipid binding attenuates channel closure of the outer membrane protein OmpF. Proceedings of the National Academy of Sciences of the United States of America, 115 (26). pp. 6691-6696. doi:10.1073/pnas.1721152115 ISSN 0027-8424.
Rao, Shanlin, Lynch, Charlotte I., Klesse, Gianni, Oakley, Georgia E., Stansfeld, Phillip J., Tucker, Stephen J. and Sansom, Mark S. P. (2018) Water and hydrophobic gates in ion channels and nanopores. Faraday Discussions, 209 . pp. 231-247. doi:10.1039/C8FD00013A ISSN 0301-7249.
El Ghachi, Meriem, Howe, Nicole, Huang, Chia-Ying, Olieric, Vincent, Warshamanage, Rangana, TouzΓ©, Thierry, Weichert, Dietmar, Stansfeld, Phillip J., Wang, Meitian, Kerff, Fred and Caffrey, Martin (2018) Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis. Nature Communications, 9 (1). 1078 . doi:10.1038/s41467-018-03477-5 ISSN 2041-1723.
Ni, Tao, Williams, Sophie I., Rezelj, SaΕ‘a, Anderluh, Gregor, Harlos, Karl, Stansfeld, Phillip J. and Gilbert, Robert J. C. (2018) Structures of monomeric and oligomeric forms of the Toxoplasma gondiiperforin-like protein 1. Science Advances, 4 (3). eaaq0762. doi:10.1126/sciadv.aaq0762 ISSN 2375-2548.
DomaΕski, Jan, Sansom, Mark S. P., Stansfeld, Phillip J. and Best, Robert B. (2018) Balancing force field proteinβlipid interactions to capture transmembrane HelixβHelix association. Journal of Chemical Theory and Computation, 14 (3). pp. 1706-1715. doi:10.1021/acs.jctc.7b00983 ISSN 1549-9618.
Newport, Thomas D., Sansom, Mark S. P. and Stansfeld, Phillip J. (2018) The MemProtMD database : a resource for membrane-embedded protein structures and their lipid interactions. Nucleic Acids Research, 47 (D1). D390-D397. doi:10.1093/nar/gky1047 ISSN 0305-1048.
DomaΕski, Jan, Hedger, George, Best, Robert B., Stansfeld, Phillip J. and Sansom, Mark S. P. (2017) Convergence and sampling in determining free energy landscapes for membrane protein association. The Journal of Physical Chemistry B, 121 (15). pp. 3364-3375. doi:10.1021/acs.jpcb.6b08445 ISSN 1520-6106.
Habersetzer, Johann, Moore, Kristoffer, Cherry, Jon, Buchanan, Grant, Stansfeld, Phillip J. and Palmer, Tracy (2017) Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli. Open Biology, 7 (8). 170091. doi:10.1098/rsob.170091 ISSN 2046-2441.
Tolia, Niraj H, Cutts, Erin E., Laasch, Niklas, Reiter, Dirk M., Trenker, Raphael, Slater, Leanne M., Stansfeld, Phillip J. and Vakonakis, Ioannis (2017) Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions. PLoS Pathogens, 13 (8). e1006552. doi:10.1371/journal.ppat.1006552 ISSN 1553-7374.
Stansfeld, Phillip J. (2017) Computational studies of membrane proteins : from sequence to structure to simulation. Current Opinion in Structural Biology, 45 . pp. 133-141. doi:10.1016/j.sbi.2017.04.004 ISSN 0959-440X.
Wiktor, Maciej, Weichert, Dietmar, Howe, Nicole, Huang, Chia-Ying, Olieric, Vincent, Boland, CoilΓn, Bailey, Jonathan, Vogeley, Lutz, Stansfeld, Phillip J., Buddelmeijer, Nienke, Wang, Meitian and Caffrey, Martin (2017) Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis. Nature Communications, 8 (1). 15952 . doi:10.1038/ncomms15952 ISSN 2041-1723.
Rao, Shanlin, Klesse, Gianni, Stansfeld, Phillip J., Tucker, Stephen J. and Sansom, Mark S. P. (2017) A BEST example of channel structure annotation by molecular simulation. Channels, 11 (4). pp. 347-353. doi:10.1080/19336950.2017.1306163 ISSN 1933-6950.
Gupta, Kallol, Donlan, Joseph A. C., Hopper, Jonathan T. S., Uzdavinys, Povilas, Landreh, Michael, Struwe, Weston B., Drew, David, Baldwin, Andrew J., Stansfeld, Phillip J. and Robinson, Carol V. (2017) The role of interfacial lipids in stabilizing membrane protein oligomers. Nature, 541 (7637). pp. 421-424. doi:10.1038/nature20820 ISSN 0028-0836.
Alcock, Felicity, Stansfeld, Phillip J., Basit, Hajra, Habersetzer, Johann, Baker, Matthew A. B., Palmer, Tracy, Wallace, Mark I. and Berks, Ben C. (2016) Assembling the tat protein translocase. eLife, 5 . e20718. doi:10.7554/eLife.20718 ISSN 2050-084X.
LΓΆrinczi, Eva, Helliwell, Matthew, Finch, Alina, Stansfeld, Phillip J., Davies, Noel W., Mahaut-Smith, Martyn, Muskett, Frederick W. and Mitcheson, John S. (2016) Calmodulin regulates human ether Γ Go-Go 1 (hEAG1) potassium channels through interactions of the eag domain with the cyclic nucleotide binding homology domain. Journal of Biological Chemistry, 291 (34). pp. 17907-17918. doi:10.1074/jbc.M116.733576 ISSN 0021-9258.
Bolivar, Juan H., MuΓ±oz-GarcΓa, Juan C., Castro-Dopico, Tomas, Dijkman, Patricia M., Stansfeld, Phillip J. and Watts, Anthony (2016) Interaction of lipids with the neurotensin receptor 1. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (6). pp. 1278-1287. doi:10.1016/j.bbamem.2016.02.032 ISSN 0005-2736.
Gu, Yinghong, Li, Huanyu, Dong, Haohao, Zeng, Yi, Zhang, Zhengyu, Paterson, Neil G., Stansfeld, Phillip J., Wang, Zhongshan, Zhang, Yizheng, Wang, Wenjian and Dong, Changjiang (2016) Structural basis of outer membrane protein insertion by the BAM complex. Nature, 531 (7592). pp. 64-69. doi:10.1038/nature17199 ISSN 0028-0836.
Vogeley, L., El Arnaout, T., Bailey, J., Stansfeld, Phillip J., Boland, C. and Caffrey, M. (2016) Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Science, 351 (6275). pp. 876-880. doi:10.1126/science.aad3747 ISSN 0036-8075.
Li, Dianfan, Stansfeld, Phillip J., Sansom, Mark S. P., Keogh, Aaron, Vogeley, Lutz, Howe, Nicole, Lyons, Joseph A., Aragao, David, Fromme, Petra, Fromme, Raimund et al.
(2015)
Ternary structure reveals mechanism of a membrane diacylglycerol kinase.
Nature Communications, 6
(1).
10140 .
doi:10.1038/ncomms10140
ISSN 2041-1723.
Paci, Emanuele, Sharma, Satyan, Kim, Brian N., Stansfeld, Phillip J., Sansom, Mark S. P. and Lindau, Manfred (2015) A coarse grained model for a lipid membrane with physiological composition and leaflet asymmetry. PLoS One, 10 (12). e0144814. doi:10.1371/journal.pone.0144814 ISSN 1932-6203.
Cléon, François, Habersetzer, Johann, Alcock, Felicity, Kneuper, Holger, Stansfeld, Phillip J., Basit, Hajra, Wallace, Mark I., Berks, Ben C. and Palmer, Tracy (2015) The TatC component of the twin-arginine protein translocase functions as an obligate oligomer. Molecular Microbiology, 98 (1). pp. 111-129. doi:10.1111/mmi.13106 ISSN 0950-382X.
Cutts, E. E., Inglis, A., Stansfeld, Phillip J., Vakonakis, I. and Hatzopoulos, G. N. (2015) The centriolar protein CPAP G-box : an amyloid fibril in a single domain. Biochemical Society Transactions, 43 (5). pp. 838-843. doi:10.1042/BST20150082 ISSN 0300-5127.
Stansfeld, Phillip J., Goose, Joseph E., Caffrey, Martin, Carpenter, Elisabeth P., Parker, Joanne L., Newstead, Simon and Sansom, Mark S. P. (2015) MemProtMD : automated insertion of membrane protein structures into explicit lipid membranes. Structure, 23 (7). pp. 1350-1361. doi:10.1016/j.str.2015.05.006 ISSN 0969-2126.
Gu, Yinghong, Stansfeld, Phillip J., Zeng, Yi, Dong, Haohao, Wang, Wenjian and Dong, Changjiang (2015) Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD. Structure, 23 (3). pp. 496-504. doi:10.1016/j.str.2015.01.001 ISSN 0969-2126.
Wojdyla, Justyna A., Cutts, Erin, Kaminska, Renata, Papadakos, Grigorios, Hopper, Jonathan T. S., Stansfeld, Phillip J., Staunton, David, Robinson, Carol V. and Kleanthous, Colin (2015) Structure and function of the escherichia coli Tol-Pal stator protein TolR. Journal of Biological Chemistry, 290 (44). pp. 26675-26687. doi:10.1074/jbc.M115.671586 ISSN 0021-9258.
Chavent, Matthieu, Chetwynd, Alan P., Stansfeld, Phillip J. and Sansom, Mark S. P. (2014) Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain : insights into the mechanism of receptor activation. Biochemistry, 53 (42). pp. 6641-6652. doi:10.1021/bi500800x ISSN 0006-2960.
Dong, Haohao, Xiang, Quanju, Gu, Yinghong, Wang, Zhongshan, Paterson, Neil G., Stansfeld, Phillip J., He, Chuan, Zhang, Yizheng, Wang, Wenjian and Dong, Changjiang (2014) Structural basis for outer membrane lipopolysaccharide insertion. Nature, 511 (7507). pp. 52-56. doi:10.1038/nature13464 ISSN 0028-0836.
Berks, Ben C., Lea, Susan M. and Stansfeld, Phillip J. (2014) Structural biology of Tat protein transport. Current Opinion in Structural Biology, 27 . pp. 32-37. doi:10.1016/j.sbi.2014.03.003 ISSN 0959-440X.
Marzian, Stefanie, Stansfeld, Phillip J., Rapedius, Markus, RinnΓ©, Susanne, Nematian-Ardestani, Ehsan, Abbruzzese, Jennifer L., Steinmeyer, Klaus, Sansom, Mark S. P., Sanguinetti, Michael C., Baukrowitz, Thomas and Decher, Niels (2013) Side pockets provide the basis for a new mechanism of Kv channelβspecific inhibition. Nature Chemical Biology, 9 (8). pp. 507-513. doi:10.1038/nchembio.1271 ISSN 1552-4450.
Shintre, C. A., Pike, A. C. W., Li, Q., Kim, J-I., Barr, A. J., Goubin, S., Shrestha, L., Yang, J., Berridge, G., Ross, J. et al.
(2013)
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Proceedings of the National Academy of Sciences of the United States of America, 110
(24).
pp. 9710-9715.
doi:10.1073/pnas.1217042110
ISSN 0027-8424.
Rothwell, Simon W., Stansfeld, Phillip J., Bragg, Laricia, Verkhratsky, Alexej and North, R. Alan (2013) Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domain. Journal of Biological Chemistry, 289 (2). pp. 618-626. doi:10.1074/jbc.M113.529099 ISSN 0021-9258.
Stansfeld, Phillip J., Jefferys, Elizabeth E. and Sansom, Mark S. P. (2013) Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins. Structure, 21 (5). pp. 810-819. doi:10.1016/j.str.2013.03.005 ISSN 0969-2126.
Schmidt, Matthias R., Stansfeld, Phillip J., Tucker, Stephen J. and Sansom, Mark S. P. (2013) Simulation-based prediction of phosphatidylinositol 4,5-Bisphosphate binding to an ion channel. Biochemistry, 52 (2). pp. 279-281. doi:10.1021/bi301350s ISSN 0006-2960.
Hatzopoulos, Georgios N., Erat, Michèle C., Cutts, Erin, Rogala, Kacper B., Slater, Leanne M., Stansfeld, Phillip J. and Vakonakis, Ioannis (2013) Structural analysis of the G-Box domain of the microcephaly protein CPAP suggests a role in centriole architecture. Structure, 21 (11). pp. 2069-2077. doi:10.1016/j.str.2013.08.019 ISSN 0969-2126.
Quigley, A., Dong, Y. Y., Pike, A. C. W., Dong, L., Shrestha, L., Berridge, G., Stansfeld, Phillip J., Sansom, M. S. P., Edwards, A. M., Bountra, C., von Delft, F., Bullock, A. N., Burgess-Brown, N. A. and Carpenter, E. P. (2013) The structural basis of ZMPSTE24-dependent laminopathies. Science, 339 (6127). pp. 1604-1607. doi:10.1126/science.1231513 ISSN 0036-8075.
Andres-Enguix, Isabelle, Shang, Lijun, Stansfeld, Phillip J., Morahan, Julia M., Sansom, Mark S. P., Lafrenière, Ronald G., Roy, Bishakha, Griffiths, Lyn R., Rouleau, Guy A., Ebers, George C., Cader, Zameel M. and Tucker, Stephen J. (2012) Functional analysis of missense variants in the TRESK (KCNK18) K+ channel. Scientific Reports, 2 (1). 237 . doi:10.1038/srep00237 ISSN 2045-2322.
Rapedius, Markus, Schmidt, Matthias R., Sharma, Chetan, Stansfeld, Phillip J., Sansom, Mark S. P., Baukrowitz, Thomas and Tucker, Stephen J. (2012) State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels, 6 (6). pp. 473-478. doi:10.4161/chan.22153 ISSN 1933-6950.
Rollauer, Sarah E., Tarry, Michael J., Graham, James E., JÀÀskelÀinen, Mari, JÀger, Franziska, Johnson, Steven, Krehenbrink, Martin, Liu, Sai-Man, Lukey, Michael J., Marcoux, Julien et al.
(2012)
Structure of the TatC core of the twin-arginine protein transport system.
Nature, 492
(7428).
pp. 210-214.
doi:10.1038/nature11683
ISSN 0028-0836.
WemhΓΆner, Konstantin, Silbernagel, Nicole, Marzian, Stefanie, Netter, Michael F., RinnΓ©, Susanne, Stansfeld, Phillip J. and Decher, Niels (2012) A leucine zipper motif essential for gating of hyperpolarization-activated channels. Journal of Biological Chemistry, 287 (48). pp. 40150-40160. doi:10.1074/jbc.M112.378513 ISSN 0021-9258.
Lumb, Craig N., He, Ju, Xue, Yi, Stansfeld, Phillip J., Stahelin, Robert V., Kutateladze, Tatiana G. and Sansom, Mark S.P. (2011) Biophysical and computational studies of membrane penetration by the GRP1 Pleckstrin Homology Domain. Structure, 19 (9). pp. 1338-1346. doi:10.1016/j.str.2011.04.010 ISSN 0969-2126.
Stansfeld, Phillip J. and Sansom, Mark S. P. (2011) From coarse grained to atomistic : a serial multiscale approach to membrane protein simulations. Journal of Chemical Theory and Computation, 7 (4). pp. 1157-1166. doi:10.1021/ct100569y ISSN 1549-9618.
Stansfeld, Phillip J. and Sansom, Mark S.P. (2011) Molecular simulation approaches to membrane proteins. Structure, 19 (11). pp. 1562-1572. doi:10.1016/j.str.2011.10.002 ISSN 0969-2126.
MΓ€nnikkΓΆ, Roope, Stansfeld, Phillip J., Ashcroft, Alexandra S., Hattersley, Andrew T., Sansom, Mark S. P., Ellard, Sian and Ashcroft, Frances M. (2011) A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated. The Journal of Physiology, 589 (13). pp. 3071-3083. doi:10.1113/jphysiol.2011.209700 ISSN 0022-3751.
Piechotta, Paula L., Rapedius, Markus, Stansfeld, Phillip J., Bollepalli, Murali K., Erhlich, Gunter, Andres-Enguix, Isabelle, Fritzenschaft, Hariolf, Decher, Niels, Sansom, Mark S. P., Tucker, Stephen J. and Baukrowitz, Thomas (2011) The pore structure and gating mechanism of K2P channels. The EMBO Journal, 30 (17). pp. 3607-3619. doi:10.1038/emboj.2011.268 ISSN 0261-4189.
Streit, Anne K., Netter, Michael F., Kempf, Franca, Walecki, Magdalena, RinnΓ©, Susanne, Bollepalli, Murali K., Preisig-MΓΌller, Regina, Renigunta, Vijay, Daut, JΓΌrgen, Baukrowitz, Thomas, Sansom, Mark S. P., Stansfeld, Phillip J. and Decher, Niels (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 Open Pore. Journal of Biological Chemistry, 286 (16). pp. 13977-13984. doi:10.1074/jbc.M111.227884 ISSN 0021-9258.
DomaΕski, Jan, Stansfeld, Phillip J., Sansom, Mark S. P. and Beckstein, Oliver (2010) Lipidbook : a public repository for force-field parameters used in membrane simulations. Journal of Membrane Biology, 236 (3). pp. 255-258. doi:10.1007/s00232-010-9296-8 ISSN 0022-2631.
Muskett, Frederick W., Thouta, Samrat, Thomson, Steven J., Bowen, Alexander, Stansfeld, Phillip J. and Mitcheson, John S. (2010) Mechanistic insight into Humanether-Γ -go-go-related gene (hERG) K+Channel deactivation gating from the solution structure of the EAG domain. Journal of Biological Chemistry, 286 (8). pp. 6184-6191. doi:10.1074/jbc.M110.199364 ISSN 0021-9258.
Tai, Kaihsu, Stansfeld, Phillip J. and Sansom, Mark S. P. (2009) Ion-blocking sites of the Kir2.1 channel revealed by multiscale modeling. Biochemistry, 48 (36). pp. 8758-8763. doi:10.1021/bi9007808 ISSN 0006-2960.
Stansfeld, Phillip J., Hopkinson, Richard, Ashcroft, Frances M. and Sansom, Mark S. P. (2009) PIP2-Binding site in Kir channels : definition by multiscale biomolecular simulations. Biochemistry, 48 (46). pp. 10926-10933. doi:10.1021/bi9013193 ISSN 0006-2960.
Rouse, Sarah L., Carpenter, Timothy, Stansfeld, Phillip J. and Sansom, Mark S. P. (2009) Simulations of the BM2 proton channel transmembrane domain from influenza virus B. Biochemistry, 48 (42). pp. 9949-9951. doi:10.1021/bi901166n ISSN 0006-2960.
Ashmole, I., Vavoulis, D. V., Stansfeld, Phillip J., Mehta, Puja R., Feng, J. F., Sutcliffe, M. J. and Stanfield, P. R. (2009) The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth. The Journal of Physiology, 587 (20). pp. 4769-4783. doi:10.1113/jphysiol.2009.175430 ISSN 0022-3751.
Stansfeld, Phillip J., Grottesi, Alessandro, Sands, Zara A., Sansom, Mark S. P., Gedeck, Peter, Gosling, Martin, Cox, Brian, Stanfield, Peter R., Mitcheson, John S. and Sutcliffe, Michael J. (2008) Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. Biochemistry, 47 (28). pp. 7414-7422. doi:10.1021/bi800475j ISSN 0006-2960.
Hardman, Rachael M., Stansfeld, Phillip J., Dalibalta, Sarah, Sutcliffe, Michael J. and Mitcheson, John S. (2007) Activation gating of hERG potassium channels. Journal of Biological Chemistry, 282 (44). pp. 31972-31981. doi:10.1074/jbc.M705835200 ISSN 0021-9258.
Stansfeld, Phillip J., Gedeck, Peter, Gosling, Martin, Cox, Brian, Mitcheson, John S. and Sutcliffe, Michael J. (2007) Drug block of the hERG potassium channel : insight from modeling. Proteins: Structure, Function, and Bioinformatics, 68 (2). pp. 568-580. doi:10.1002/prot.21400 ISSN 0887-3585.
Yuill, K. H., Stansfeld, Phillip J., Ashmole, I., Sutcliffe, M. J. and Stanfield, P. R. (2007) The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains. PflΓΌgers Archiv - European Journal of Physiology, 455 (2). pp. 333-348. doi:10.1007/s00424-007-0282-7 ISSN 0031-6768.
Stansfeld, Phillip J., Sutcliffe, Michael J. and Mitcheson, John S. (2006) Molecular mechanisms for drug interactions with hERG that cause long QT syndrome. Expert Opinion on Drug Metabolism & Toxicology, 2 (1). pp. 81-94. doi:10.1517/17425255.2.1.81 ISSN 1742-5255.
Perry, Matthew, Stansfeld, Phillip J., Leaney, Joanne, Wood, Claire, de Groot, Marcel J., Leishman, Derek, Sutcliffe, Michael J. and Mitcheson, John S. (2005) Drug binding interactions in the inner cavity of hERG channels : molecular insights from structure-activity relationships of clofilium and ibutilide analogs. Molecular Pharmacology, 69 (2). pp. 509-519. doi:10.1124/mol.105.016741 ISSN 0026-895X.
Chen, Philip E., Geballe, Matthew T., Stansfeld, Phillip J., Johnston, Alexander R., Yuan, Hongjie, Jacob, Amanda L., Snyder, James P., Traynelis, Stephen F. and Wyllie, David J. A. (2005) Structural features of the glutamate binding site in recombinant NR1/NR2A N-Methyl-d-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Molecular Pharmacology, 67 (5). pp. 1470-1484. doi:10.1124/mol.104.008185 ISSN 0026-895X.
Book Item
Corey, Robin A., Sansom, Mark S. P. and Stansfeld, Phillip J. (2021) Identification and characterization of specific proteinβlipid interactions using molecular simulation. In: Moreira, I. S. and Machuqueiro, M. and MourΓ£o, J., (eds.) Computational Design of Membrane Proteins. Methods in Molecular Biology, 2315 . Springer US, pp. 121-139. ISBN 9781071614679
Tai, Kaihsu, Fowler, Philip, Mokrab, Younes, Stansfeld, Phillip J. and Sansom, Mark S.P. (2008) Molecular modeling and simulation studies of ion channel structures, dynamics and mechanisms. In: Methods in Nano Cell Biology. UNSPECIFIED, pp. 233-265.
Kirton, Stewart B., Stansfeld, Phillip J., Mitcheson, John S. and Sutcliffe, Michael J. (2007) Homology models applied to toxicology. In: Ekins, Sean, (ed.) Computational Toxicology. Wiley-Blackwell Publishing Ltd., pp. 433-468. ISBN 9780470049624
Journal Item
Brown, Chelsea M., Corey, Robin A., Gao, Ya, Kyo Choi, Yeol, Gilleron, Martine, Destainville, Nicolas, Fullam, Elizabeth, Im, Wonpil, Chavent, Matthieu G. and Stansfeld, Phillip J. (2023) Supramolecular organisation and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane. Biophysical Journal, 122 (3). 136a. ISSN 0006-3495 doi:10.1016/j.bpj.2022.11.897
Dataset
Cassidy, Keith, Burt, Alister, Stansfeld, Phillip J. and Gutsche, Irina (2021) Data for Alternative architecture of the E. coli chemosensory array. [Dataset]
This list was generated on Fri Mar 29 06:40:36 2024 GMT.