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Number of items: 250.
2023
Cao, Kaiming, Zhu, Yang, Hou, Zhuanghao, Liu, Manman, Yang, Yanyan, Hu, Hongze, Dai, Yi, Wang, Yu, Yuan, Siming, Huang, Guangming, Mei, Jiaming, Sadler, Peter J. and Liu, Yangzhong (2023) Ξ±-Synuclein as a target for metallo-anti-neurodegenerative agents. Angewandte Chemie International Edition, 62 (1). e202215360. doi:10.1002/anie.202215360 ISSN 1433-7851.
2022
Wang, Fang-Xin, Prokes, Ivan, Song, Lijiang, Shi, Huayun and Sadler, Peter J. (2022) Reactions of cisplatin and oxaliplatin with penicillin G : implications for drug inactivation and biological activity. JBIC Journal of Biological Inorganic Chemistry, 27 . pp. 695-704. doi:10.1007/s00775-022-01958-z ISSN 0949-8257.
Shi, Huayun and Sadler, Peter J. (2022) Advances in the design of photoactivated platinum anticancer complexes. Advances in Inorganic Chemistry, 80 . pp. 95-127. doi:10.1016/bs.adioch.2022.07.001 ISSN 0898-8838.
Sink, Alexandra, Banerjee, Samya, Wolny, Juliusz A., Imberti, Cinzia, Lant, Edward C., Walker, Marc, SchΓΌnemann, Volker and Sadler, Peter J. (2022) Kinetics and mechanism of sequential ring methyl CβH activation in cyclopentadienyl rhodium(iii) complexes. Dalton Transactions, 51 (42). pp. 16070-16081. doi:10.1039/D2DT02079C ISSN 1477-9226.
Frei, Angelo, Elliott, Alysha G., Kan, Alex, Dinh, Hue, BrΓ€se, Stefan, Bruce, Alice E., Bruce, Mitchell R., Chen, Feng, Humaidy, Dhirgam, Jung, Nicole et al.
(2022)
Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments.
JACS Au, 2
(10).
pp. 2277-2294.
doi:10.1021/jacsau.2c00308
ISSN 2691-3704.
Zhu, Zilin, Wei, Li, Lai, Yidan, Carter, Oliver W. L., Banerjee, Samya, Sadler, Peter J. and Huang, Huaiyi (2022) Photocatalytic glucose-appended bio-compatible Ir(iii) anticancer complexes. Dalton Transactions, 51 (29). pp. 10875-10879. doi:10.1039/d2dt01134d ISSN 1477-9234.
Bisceglie, Franco, Pelosi, Giorgio, Orsoni, NicolΓ², Pioli, Marianna, Carcelli, Mauro, Pelagatti, Paolo, Pinelli, Silvana and Sadler, Peter J. (2022) Light triggers the antiproliferative activity of naphthalimide-conjugated (Ξ·6-arene)ruthenium(II) complexes. International Journal of Molecular Sciences, 23 (14). 7624. doi:10.3390/ijms23147624 ISSN 1422-0067.
Chen, Feng, Romero-CanelΓ³n, Isolda, Habtemariam, Abraha, Song, Ji-Inn, Banerjee, Samya, Clarkson, Guy J., Song, Lijiang, Prokes, Ivan and Sadler, Peter J. (2022) Effect of cysteine thiols on the catalytic and anticancer activity of Ru(ii) sulfonyl-ethylenediamine complexes. Dalton Transactions, 51 (11). pp. 4447-4457. doi:10.1039/D1DT03856G ISSN 1477-9226.
Farley, Sarah J., Salassa, Luca, Pizarro, Ana M. and Sadler, Peter J. (2022) Photoactive platinum(II) azopyridine complexes. Photochemistry and Photobiology, 98 (1). pp. 92-101. doi:10.1111/php.13405 ISSN 0031-8655.
2021
Bolitho, Elizabeth, Sanchez-Cano, Carlos, Shi, Huayun, Quinn, Paul D., Harkiolaki, Maria, Imberti, Cinzia and Sadler, Peter J. (2021) Single-cell chemistry of photoactivatable platinum anticancer complexes. Journal of the American Chemical Society, 143 (48). pp. 20224-20240. doi:10.1021/jacs.1c08630 ISSN 1520-5126.
Needham, Russell J., Prokes, Ivan, Habtemariam, Abraha, Romero-CanelΓ³n, Isolda, Clarkson, Guy J. and Sadler, Peter J. (2021) NMR studies of group 8 metallodrugs : 187Os-enriched organo-osmium half-sandwich anticancer complex. Dalton Transactions, 50 (37). pp. 12970-12981. doi:10.1039/d1dt02213j ISSN 1477-9234.
Wang, Fang-Xin, Liu, Jie-Wei, Hong, Xiao-Qiao, Tan, Cai-Ping, Zhang, Li, Chen, Wen-Hua, Sadler, Peter J. and Mao, Zong-Wan (2021) Anion-responsive manganese porphyrin facilitates chloride transport and induces immunogenic cell death. CCS Chemistry, 5 (7). pp. 2409-2419. doi:10.31635/ccschem.021.202101212 ISSN 2096-5745.
Shi, Huayun, Kasparkova, Jana, SouliΓ©, ClΓ©ment, Clarkson, Guy J., Imberti, Cinzia, Novakova, Olga, Paterson, Martin J., Brabec, Viktor and Sadler, Peter J. (2021) DNAβintercalative platinum anticancer complexes photoactivated by visible light. Chemistry β A European Journal, 27 (41). pp. 10711-10716. doi:10.1002/chem.202101168 ISSN 1521-3765.
Everett, James, Lermyte, Frederik, Brooks, Jake, Tjendana-Tjhin, Vindy, Plascencia-Villa, G., Hands-Portman, Ian, Donnelly, Jane M., Billimoria, Kharmen, Perry, G. H., Zhu, X., Sadler, P. J., O'Connor, Peter B., Collingwood, Joanna F. and Telling, N.D. (2021) Biogenic metallic elements in the human brain? Science Advances, 7 (24). eabf6707. doi:10.1126/sciadv.abf6707 ISSN 2375-2548.
Coverdale, James P. C., Guy, Collette S., Bridgewater, Hannah E., Needham, Russell J., Fullam, Elizabeth and Sadler, Peter J. (2021) Osmiumβarene complexes with high potency towards Mycobacterium tuberculosis. Metallomics, 13 (4). mfab007. doi:10.1093/mtomcs/mfab007 ISSN 1756-5901.
Bolitho, Elizabeth, Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez-Cano, Carlos and Sadler, Peter J. (2021) Tracking reactions of asymmetric organo-osmium transfer hydrogenation catalysts in cancer cells. Angewandte Chemie International Edition, 60 (12). pp. 6462-6472. doi:10.1002/anie.202016456 ISSN 1433-7851.
Kumar, Swati, Needham, Russell J., Abraham, Kristin, Bridgewater, Hannah E., Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, SΓ©bastien, Sadler, Peter J. and LΓ©vi, Francis A. (2021) Dose and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice. Metallomics, 13 (2). mfaa003. doi:10.1093/mtomcs/mfaa003 ISSN 1756-5901.
2020
Donnelly, Jane M., Lermyte, Frederik, Wolny, Juliusz A., Walker, M., Breeze, B. G., Needham, Russell J., MΓΌller, C. S., O'Connor, Peter B., SchΓΌnemann, Volker, Collingwood, Joanna F. and Sadler, Peter J. (2020) Data for Cu(III)βbis-thiolato complex forms an unusual mono-thiolato Cu(III)βperoxido adduct. [Dataset]
Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, Vindy Tjendana, Sadler, Peter J., Telling, Neil D. and Collingwood, Joanna F. (2020) Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. Journal of Trace Elements in Medicine and Biology, 62 . 126555. doi:10.1016/j.jtemb.2020.126555 ISSN 0946-672X.
Shi, Huayun, Imberti, Cinzia, Clarkson, Guy J. and Sadler, Peter J. (2020) Axial functionalisation of photoactive diazido platinum(IV) anticancer complexes. Inorganic Chemistry Frontiers, 7 (19). pp. 3533-3540. doi:10.1039/D0QI00685H ISSN 2052-1553.
Novohradsky, Vojtech, Pracharova, Jitka, Kasparkova, Jana, Imberti, Cinzia, Bridgewater, Hannah E., Sadler, Peter J. and Brabec, Viktor (2020) Induction of immunogenic cell death in cancer cells by a photoactivated platinum(iv) prodrug. Inorganic Chemistry Frontiers, 7 (21). pp. 4150-4159. doi:10.1039/d0qi00991a ISSN 2052-1553.
Shi, Huayun, Imberti, Cinzia, Clarkson, Guy J. and Sadler, Peter J. (2020) Data for Axial functionalisation of photoactive diazido platinum(IV) anticancer complexes. [Dataset]
Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, Vindy Tjendana, Sadler, P. J., Telling, Neil D. and Collingwood, Joanna F. (2020) Data for Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. [Dataset]
Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, Vindy Tjendana , Banerjee, Samya, OβConnor, Peter B., Morrison, Christopher M. , Sadler, Peter J., Telling, Neil D. and Collingwood, Joanna F. (2020) Label-free nano-imaging of neuromelanin in the brain by soft x-ray spectromicroscopy. Angewandte Chemie (International Edition), 59 (29). pp. 11984-11991. doi:10.1002/anie.202000239 ISSN 1433-7851.
Shi, Huayun and Sadler, Peter J. (2020) How promising is phototherapy for cancer? British Journal of Cancer, 123 . pp. 871-873. ISSN 0007-0920 doi:10.1038/s41416-020-0926-3
Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-CanelΓ³n, Isolda, Zeng, Musheng, Habtemariam, Abraha and Sadler, Peter J. (2020) Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta, 503 . 119396. doi:10.1016/j.ica.2019.119396 ISSN 0020-1693.
Zhang, Wen-Ying, Bridgewater, Hannah E., Banerjee, Samya, Soldevila-Barreda, Joan J., Clarkson, Guy J., Shi, Huayun, Imberti, Cinzia and Sadler, Peter J. (2020) Ligand-controlled reactivity and cytotoxicity of cyclometalated rhodium(III) complexes. European Journal of Inorganic Chemistry, 2020 (11-12). pp. 1052-1060. doi:10.1002/ejic.201901055 ISSN 1434-1948.
Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Biotinylated photoactive Pt(IV) anticancer complexes. Chemical Communications, 56 (15). pp. 2320-2323. doi:10.1039/c9cc07845b ISSN 1359-7345.
Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Data for Biotinylated photoactive Pt(IV) anticancer complexes. [Dataset]
2019
Banerjee, Samya, Capper, Miles S., Clarkson, Guy J., Huang, Huaiyi and Sadler, Peter J. (2019) Dual-action platinum(II) Schiff base complexes : photocytotoxicity and cellular imaging. Polyhedron, 172 . pp. 157-166. doi:10.1016/j.poly.2019.04.024 ISSN 0277-5387.
Huang, Huaiyi, Banerjee, Samya, Qiu, Kangqiang, Zhang, Pingyu, Blacque, Olivier, Malcomson, Thomas, Paterson, Martin J., Clarkson, Guy J., Staniforth, Michael, Stavros, Vasilios G., Gasser, Gilles, Chao, Hui and Sadler, Peter J. (2019) Targeted photoredox catalysis in cancer cells. Nature Chemistry, 11 . pp. 1041-1048. doi:10.1038/s41557-019-0328-4 ISSN 1755-4330.
Lermyte, Frederik, Everett, James, Brooks, Jake, Bellingeri, Francesca, Billimoria, Kharmen, Sadler, Peter J., OβConnor, Peter B., Telling, Neil D. and Collingwood, Joanna F. (2019) Emerging approaches to investigate the influence of transition metals in the proteinopathies. Cells, 8 (10). 1231. doi:10.3390/cells8101231 ISSN 2073-4409.
Lermyte, Frederik, Everett, James, Lam, Yuko P. Y., Wootton, Christopher, Brooks, Jake, Barrow, Mark P., Telling, Neil D., Sadler, P. J., O'Connor, Peter B. and Collingwood, Joanna F. (2019) Data for Metal ion binding to the amyloid beta monomer studied by native top-down FTICR mass spectrometry. [Dataset]
Lermyte, Frederik, Everett, James, Lam, Yuko P. Y., Wootton, Christopher, Brooks, Jake, Barrow, Mark P., Telling, Neil D., Sadler, P. J., O'Connor, Peter B. and Collingwood, Joanna F. (2019) Metal ion binding to the amyloid beta monomer studied by native top-down FTICR mass spectrometry. Journal of The American Society for Mass Spectrometry, 30 (10). pp. 2123-2134. doi:10.1007/s13361-019-02283-7 ISSN 1044-0305.
Banerjee, Samya, Omlor, Andreas, Wolny, Juliusz A., Han, Yisong, Lermyte, Frederik, Godfrey, Amy, O'Connor, Peter B., SchΓΌnemann, Volker, Danaie, Mohsen and Sadler, Peter J. (2019) Generation of maghemite nanocrystals from ironβsulfur centres. Dalton Transactions, 48 (26). pp. 9564-9569. doi:10.1039/C9DT00514E ISSN 1477-9226.
Shi, Huayun, Imberti, Cinzia and Sadler, P. J. (2019) Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy. Inorganic Chemistry Frontiers, 6 (7). pp. 1623-1638. doi:10.1039/c9qi00288j ISSN 2052-1553.
Shi, Huayun, Wang, Qian, Venkatesh, Venkatesh, Feng, Guokai, Young, Lawrence S., Romero-CanelΓ³n, Isolda, Zeng, Musheng and Sadler, P. J. (2019) Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide. Dalton Transactions, 48 (24). pp. 8560-8564. doi:10.1039/c9dt00909d ISSN 1477-9226.
Shi, Huayun, Clarkson, Guy J. and Sadler, Peter J. (2019) Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands. Inorganica Chimica Acta, 489 . pp. 230-235. doi:10.1016/j.ica.2019.02.016 ISSN 0020-1693.
Wootton, Christopher, Millett, Adam J., Lopez-Clavijo, Andrea F., Chiu, Cookson, Barrow, Mark P., Clarkson, Guy J., Sadler, P. J. and O'Connor, Peter B. (2019) Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. Analyst, 144 (5). pp. 1575-1581. doi:10.1039/C8AN02094A ISSN 0003-2654.
Zhang, Pingyu, Huang, Huaiyi, Banerjee, Samya, Clarkson, Guy J., Ge, Chen, Imberti, Cinzia and Sadler, Peter J. (2019) Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy. Angewandte Chemie International Edition, 58 (8). pp. 2350-2354. doi:10.1002/anie.201813002 ISSN 1433-7851.
Gondim, Ana C. S., Roberta da Silva, Suzete, Mathys, Leen, Noppen, Sam, Liekens, Sandra, Holanda Sampaio, Alexandre, Nagano, Celso S., Renata Costa Rocha, Cintia, Nascimento, Kyria S., Cavada, Benildo S., Sadler, Peter J. and Balzarini, Jan (2019) Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity. MedChemComm, 10 (3). pp. 390-398. doi:10.1039/c8md00508g ISSN 2040-2503.
2018
Shi, Huayun, Romero-CanelΓ³n, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, Venkatesh, Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, P. J. (2018) Photoactivatable cell-selective dinuclear trans diazido platinum(IV) anticancer prodrugs. Inorganic Chemistry, 57 (22). pp. 14409-14420. doi:10.1021/acs.inorgchem.8b02599 ISSN 0020-1669.
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16). pp. 7330-7344. doi:10.1021/acs.jmedchem.8b00906 ISSN 1520-4804.
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Data for Biguanide iridium(III) complexes with potent antimicrobial activity. [Dataset]
Farrer, Nicola J., Sharma, Gitanjali, Sayers, Rachel, Shaili, Evyenia and Sadler, P. J. (2018) Platinum(iv) azido complexes undergo copper-free click reactions with alkynes. Dalton Transactions, 47 (31). pp. 10553-10560. doi:10.1039/c7dt04183g ISSN 1477-9234.
Sanchez-Cano, Carlos, Romero-CanelΓ³n, Isolda, Gerakic, Kalotina and Sadler, P. J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014 ISSN 0162-0134.
Sanchez-Cano, Carlos, Romero-CanelΓ³n, Isolda, Geraki, Kalotina and Sadler, Peter J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organoβosmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014 ISSN 0162-0134.
Huang, Huaiyi, Banerjee, Samya and Sadler, Peter J. (2018) Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy. Chembiochem, 19 (15). pp. 1574-1589. doi:10.1002/cbic.201800182 ISSN 1439-4227.
Gothe, Yvonne, Romero-CanelΓ³n, Isolda, Marzo, Tiziano, Sadler, P. J., Messori, Luigi and Metzler-Nolte, Nils (2018) Synthesis and mode of action studies on Iridium(I)-NHC anticancer drug candidates. European Journal of Inorganic Chemistry, 2018 (20-21). pp. 2461-2470. doi:10.1002/ejic.201800225 ISSN 1434-1948.
Martin, Esther M., Kondrat, Frances D. L., Stewart, Alan J., Scrivens, James H., Sadler, P. J. and Blindauer, Claudia A. (2018) Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein. Scientific Reports, 8 (1). 8646. doi:10.1038/s41598-018-26924-1 ISSN 2045-2322.
Chen, Feng, Romero-CanelΓ³n, Isolda, Soldevila-Barreda, Joan J., Song, Ji-Inn, Coverdale, James P. C., Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Wills, Martin, Brabec, Viktor and Sadler, P. J. (2018) Transfer hydrogenation and antiproliferative activity of tethered half-sandwich organoruthenium catalysts. Organometallics, 37 (10). pp. 1555-1566. doi:10.1021/acs.organomet.8b00132 ISSN 0276-7333.
Sadler, P. J., Vernooij, Robbin, Joshi, Tanmaya, Horbury, Michael D., Graham, Bim, Izgorodina, Ekaterina I., Stavros, Vasilios G., Spiccia, Leone and Wood, Bayden R. (2018) Spectroscopic studies on photoinduced reactions of the anticancer prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]. Chemistry - A European Journal, 24 (22). pp. 5790-5803. doi:10.1002/chem.201705349 ISSN 0947-6539.
Chen, Feng, Soldevila-Barreda, Joan J., Romero-CanelΓ³n, Isolda, Coverdale, James P. C., Song, Ji-Inn, Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Brabec, Viktor, Wolny, Juliusz A., SchΓΌnemann, Volker and Sadler, P. J. (2018) Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate. Dalton Transactions, 47 (21). 7178-7189 . doi:10.1039/C8DT00438B ISSN 1477-9234.
Chellan , Prinessa, Avery, Vicky M., Duffy, Sandra, Triccas, James A., Nagalingam, Gayathri, Tam, Christina, Cheng, Luisa W., Liu, Jenny, Land, Kirkwood M., Clarkson, Guy J., Romero-CanelΓ³n, Isolda and Sadler, Peter J. (2018) Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance. Chemistry - A European Journal, 24 (40). pp. 10078-10090. doi:10.1002/chem.201801090 ISSN 0947-6539.
Banerjee, Samya, Soldevila-Barreda, Joan J., Wolny, Juliusz A., Wootton, Christopher, Habtemariam, Abraha, Romero-CanelΓ³n, Isolda, Chen, Feng, Clarkson, Guy J., Prokes, Ivan, Song, Lijiang, O'Connor, Peter B., SchΓΌnemann, Volker and Sadler, P. J. (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science, 9 (12). pp. 3177-3185. doi:10.1039/c7sc05058e ISSN 2041-6539.
Gatti, Anna, Habtemariam, Abraha, Romero-CanelΓ³n, Isolda, Song, Ji-Inn, Heer, Bindy, Clarkson, Guy J., Rogolino, Dominga, Sadler, P. J. and Carcelli, Mauro (2018) Half-sandwich arene ruthenium(II) and osmium(II) thiosemicarbazone complexes : solution behavior and antiproliferative activity. Organometallics, 37 (6). pp. 891-899. doi:10.1021/acs.organomet.7b00875 ISSN 0276-7333.
Wootton, Christopher, Sanchez-Cano, Carlos, Lopez-Clavijo, Andrea F., Shaili, Evyenia, Barrow, Mark P., Sadler, P. J. and O'Connor, Peter B. (2018) Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes. Chemical Science, 9 . pp. 2733-2739. doi:10.1039/C7SC05135B ISSN 2041-6520.
Larnaudie, Sophie, Brendel, Johannes C., Romero-CanelΓ³n, Isolda, Sanchez-Cano, Carlos, Catrouillet, Sylvain, Sanchis, Joaquin, Coverdale, James P. C., Song, Ji-Inn, Habtemariam, Abraha, Sadler, P. J., Jolliffe, Katrina A. and Perrier, SΓ©bastien (2018) Cyclic peptideβpolymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes. Biomacromolecules, 19 (1). pp. 239-247. doi:10.1021/acs.biomac.7b01491 ISSN 1526-4602.
Coverdale, James P. C., Romero-CanelΓ³n, Isolda, Sanchez-Cano, Carlos, Clarkson, Guy J., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2018) Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells. Nature Chemistry, 10 . pp. 347-354. doi:10.1038/nchem.2918 ISSN 1755-4330.
Shi, Huayun, Romero-CanelΓ³n, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, V., Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, Peter J. (2018) Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs. [Dataset]
Hearn, Jessica M., Hughes, George Marc, Romero-CanelΓ³n, Isolda, Munro, Alison F., Rubio-Ruiz, BelΓ©n, Liu, Zhe, Carragher, Neil O. and Sadler, P. J. (2018) Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Metallomics, 10 (1). 93-107 . doi:10.1039/C7MT00242D ISSN 1756-5901.
Venkatesh, Venkatesh and Sadler, P. J. (2018) Platinum(IV) prodrugs. In: Sigel, Astrid and Sigel, Helmut and Freisinger, Eva and Sigel, Roland K.O., (eds.) Metallo-Drugs: Development and Action of Anticancer Agents. Metal Ions in Life Sciences, 18 . De Gruyter, pp. 69-108. ISBN 9783110470734
2017
Zhang, Pingyu, Chiu, Cookson K. C., Huang, Huayi, Lam, Yuko P. Y., Habtemariam, Abraha, Malcomson, Thomas, Paterson, Martin J., Clarkson, Guy J., O'Connor, Peter B., Chao, Hui and Sadler, P. J. (2017) Organoiridium photosensitizers induce specific oxidative attack on proteins within cancer cells. Angewandte Chemie International Edition, 56 (47). pp. 14898-14902. doi:10.1002/anie.201709082 ISSN 1433-7851.
Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014 ISSN 0162-0134.
Gondim, Ana C. S., Romero-CanelΓ³n, Isolda, Sousa, Eduardo H.S., Blindauer, Claudia A., Butler, Jennifer S., Romero, Maria, Sanchez-Cano, Carlos, Sousa, Bruno L., Chaves, Renata P., Nagano, Celso S., Cavada, Benildo S. and Sadler, P. J. (2017) The potent anti-cancer activity of Dioclea lasiocarpa lectin. Journal of Inorganic Biochemistry, 175 . pp. 179-189. doi:10.1016/j.jinorgbio.2017.07.011 ISSN 0162-0134.
McQuitty, Ruth J., Unterkofler, Sarah, Euser, Tijmen G., Russell, Philip St. J. and Sadler, P. J. (2017) Rapid screening of photoactivatable metallodrugs : photonic crystal fibre microflow reactor coupled to ESI mass spectrometry. RSC Advances , 7 (59). pp. 37340-37348. doi:10.1039/c7ra06735f ISSN 2046-2069.
Zhang, Pingyu and Sadler, Peter J. (2017) Advances in the design of organometallic anticancer complexes. Journal of Organometallic Chemistry, 839 . pp. 5-14. doi:10.1016/j.jorganchem.2017.03.038 ISSN 0022-328X.
Sadler, Peter J. (2017) Biosketch of Peter J. Sadler. Journal of Organometallic Chemistry, 839 . pp. 2-4. ISSN 0022-328X doi:10.1016/j.jorganchem.2017.04.020
Venkatesh, Venkatesh, Mishra, Narendra, Romero-CanelΓ³n, Isolda, Vernooij, Robbin, Shi, Huayun, Coverdale, James P. C., Habtemariam, Abraha, Verma, Sandeep and Sadler, P. J. (2017) Supramolecular photoactivatable anticancer hydrogels. Journal of the American Chemical Society, 139 (16). pp. 5656-5659. doi:10.1021/jacs.7b00186 ISSN 0002-7863.
Needham, Russell J., Sanchez-Cano, Carlos, Zhang, Xin, Romero-CanelΓ³n, Isolda, Habtemariam, Abraha, Cooper, Margaret S., Meszaros, Levente, Clarkson, Guy J., Blower, Philip J. and Sadler, P. J. (2017) In-cell activation of organo-osmium(II) anticancer complexes. Angewandte Chemie International Edition, 56 (4). pp. 1017-1020. doi:10.1002/anie.201610290 ISSN 1433-7851.
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Venkatesh, Venkatesh, Berrocal-Martin, Raul, Wedge, Christopher, Romero-CanelΓ³n, Isolda, Sanchez-Cano, Carlos, Song, Ji-Inn, Coverdale, James P. C., Zhang, Pingyu, Clarkson, Guy J., Habtemariam, Abraha, Magennis, Steven W., Deeth, Robert J. and Sadler, P. J. (2017) Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes. Chemical Science, 8 (12). pp. 8271-8278. doi:10.1039/C7SC03216A ISSN 2041-6520.
2016
Liu, Hong-Ke, Kostrhunova, Hana, Habtemariam, Abraha, Kong, Yaqiong, Deeth, Robert J., Brabec, Viktor and Sadler, P. J. (2016) "Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes. Dalton Transactions, 45 . pp. 18676-18688. doi:10.1039/c6dt03356c ISSN 1477-9226.
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Ude, Ziga, Romero-CanelΓ³n, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)βarene complex of an anti-microbial ciprofloxacin derivative β anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018 ISSN 0162-0134.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-CanelΓ³n, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Venkatesh, Venkatesh, Wedge, Christopher, Romero-CanelΓ³n, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions, 45 . pp. 13034-13037. doi:10.1039/C6DT01382A ISSN 1477-9226.
Vernooij, Robbin, Joshi, Tanmaya, Shaili, Evyenia, Kubeil, Manja, Appadoo, Dominique R. T., Izgorodina, Ekaterina I., Graham, Bim, Sadler, P. J., Wood, Bayden R. and Spiccia, Leone (2016) Data for Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. [Dataset]
Venkatesh, Venkatesh, Wedge, Christopher, Romero-CanelΓ³n, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Data for Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex. [Dataset]
Pitto-Barry, AnaΓ―s, Sadler, P. J. and Barry, Nicolas P. E. (2016) Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications, 52 (20). pp. 3895-3898. c5cc09564f. doi:10.1039/c5cc09564f ISSN 1359-7345.
Vernooij, Robbin, Joshi, Tanmaya, Shaili, Evyenia, Kubeil, Manja, Appadoo, Dominique R. T., Izgorodina, Ekaterina I., Graham, Bim, Sadler, P. J., Wood, Bayden R. and Spiccia, Leone (2016) Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. Inorganic Chemistry, 55 (12). pp. 5983-5992. doi:10.1021/acs.inorgchem.6b00476 ISSN 0020-1669.
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, FlorΓͺncio S., Silva da Silva, Carlos Daniel, Wink, David A., de FranΓ§a Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1Ξ± inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
2015
Soldevila-Barreda, Joan J., Habtemariam, Abraha, Romero-CanelΓ³n, Isolda and Sadler, P, J. (2015) Half-sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry, 153 . pp. 322-333. doi:10.1016/j.jinorgbio.2015.10.008 ISSN 0162-0134.
Romero-CanelΓ³n, Isolda, Phoenix, Ben, Pitto-Barry, AnaΓ―s, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolatoβcarborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
Pitto-Barry, AnaΓ―s, Alves PerdigΓ£o, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a ISSN 1477-9226.
Romero-CanelΓ³n, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Zou, Taotao and Sadler, P. J. (2015) Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today : Technologies, 16 . pp. 7-15. doi:10.1016/j.ddtec.2015.08.002 ISSN 1740-6749.
Barry, Nicolas P. E., Pitto-Barry, AnaΓ―s, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., OβReilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853 ISSN 0897-4756.
Millett, Adam J., Habtemariam, Abraha, Romero-CanelΓ³n, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097 ISSN 0276-7333.
Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
Soldevila-Barreda, Joan J., Romero-CanelΓ³n, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182 ISSN 1364-503X.
Wootton, Christopher, Sanchez-Cano, Carlos, Liu, Hong, Barrow, Mark P., Sadler, P. J. and O'Connor, Peter B. (2015) Binding of an organoβosmium(ii) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution TopβDown FT-ICR mass spectrometry. Dalton Transactions, 44 (8). pp. 3624-3632. doi:10.1039/C4DT03819C ISSN 1477-9226.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
2014
Sousa, Eduardo Henrique Silva, de Mesquita Vieira, Francisca Gilmara, Butler, Jennifer S. (Jennifer Suzanne), Basso, Luiz Augusto, Santiago, DiΓ³genes S., DiΓ³genes, Izaura C.N., Lopes, Luiz Gonzaga de FranΓ§a and Sadler, P. J. (2014) [Fe(CN)5(isoniazid)]3β: an iron isoniazid complex with redox behavior implicated in tuberculosis therapy. Journal of Inorganic Biochemistry, Volume 140 . pp. 236-244. doi:10.1016/j.jinorgbio.2014.08.002 ISSN 0162-0134.
Barry, Nicolas P. E., Pitto-Barry, AnaΓ―s, Romero-CanelΓ³n, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Liu, Zhe , Romero-CanelΓ³n, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing Cβ§N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f ISSN 0276-7333.
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and OβConnor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
Barry, Nicolas P. E., Pitto-Barry, AnaΓ―s, SΓ‘nchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-CanelΓ³n, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Barry, Nicolas P. E., Kemp, Thomas F., Sadler, P. J. and Hanna, John V. (2014) A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes. Dalton Transactions, Volume 43 (Number 13). pp. 4945-4949. doi:10.1039/c3dt53589d ISSN 1477-9226.
Liu, Zhe , Romero-CanelΓ³n, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
2013
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Barry, Nicolas P. E., Deeth, Robert J., Clarkson, Guy J., Prokes, Ivan and Sadler, P. J. (2013) Thermochromic organometallic complexes: experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(ii) carboranes with aromatic amine ligands. Dalton Transactions, Volume 42 (Number 7). pp. 2580-2587. doi:10.1039/c2dt32650g ISSN 1477-9226.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028 ISSN 0304-4165.
Lin, Yu, Huang, Yongdong, Zheng, Wei, Wang, Fuyi, Habtemariam, Abraha, Luo, Qun, Li, Xianchan, Wu, Kui, Sadler, P. J. and Xiong, Shaoxiang (2013) Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase Ο. Journal of Inorganic Biochemistry, Volume 128 . pp. 77-84. doi:10.1016/j.jinorgbio.2013.07.029 ISSN 0162-0134.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Wang, Fuyi, Xu, Jingjing, Wu, Kui, Weidt, Stefan K., Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2013) Competition between glutathione and DNA oligonucleotides for ruthenium(ii) arene anticancer complexes. Dalton Transactions, Volume 42 (Number 9). pp. 3188-3195. doi:10.1039/c2dt32091f ISSN 1477-9226.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Barry, Nicolas P. E. and Sadler, P. J. (2013) Challenges for metals in medicine : how nanotechnology may help to shape the future. ACS Nano, Volume 7 (Number 7). pp. 5654-5659. doi:10.1021/nn403220e ISSN 1936-0851.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Hearn, Jessica M., Romero-CanelΓ³n, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Cubillas, Ana M., Unterkofler, Sarah, Euser, Tijmen G., Etzold, Bastian J. M., Jones, Anita C., Sadler, P. J., Wasserscheid, Peter and Russell, Philip St.J. (2013) Photonic crystal fibres for chemical sensing and photochemistry. Chemical Society Reviews . doi:10.1039/c3cs60128e ISSN 0306-0012.
Barry, Nicolas P. E. and Sadler, P. J. (2013) Exploration of the medical periodic table : towards new targets. Chemical Communications, Volume 49 (Number 45). pp. 5106-5131. doi:10.1039/c3cc41143e ISSN 1359-7345.
Borfecchia, Elisa, Garino, Claudio, Salassa, Luca, Ruiu, Tiziana, Gianolio, Diego, Zhang, Xiaoyi, Attenkofer, Klaus, Chen, Lin X., Gobetto, Roberto, Sadler, P. J. and Lamberti, Carlo (2013) X-ray transient absorption structural characterization of the 3MLCT triplet excited state of cis-[Ru(bpy)2(py)2]2+. Dalton Transactions, Volume 42 (Number 18). pp. 6564-6571. doi:10.1039/c3dt32865a ISSN 1477-9226.
Liu, Zhe , Deeth, Robert J., Butler, Jennifer S. (Jennifer Suzanne), Habtemariam, Abraha, Newton, Mark E. and Sadler, P. J. (2013) Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie International Edition, Volume 52 (Number 15). pp. 4194-4197. doi:10.1002/anie.201300747 ISSN 1433-7851.
Butler, Jennifer S. (Jennifer Suzanne) and Sadler, P. J. (2013) Targeted delivery of platinum-based anticancer complexes. Current Opinion in Chemical Biology, Volume 17 (Number 2). pp. 175-188. doi:10.1016/j.cbpa.2013.01.004 ISSN 1367-5931.
Scotcher, Jenna, Clarke, David J., Mackay, C. Logan, Hupp, Ted R., Sadler, P. J. and Langridge-Smith, Pat R. R. (2013) Redox regulation of tumour suppressor protein p53 : identification of the sites of hydrogen peroxide oxidation and glutathionylation. Chemical Science, Volume 4 (Number 3). pp. 1257-1269. doi:10.1039/c2sc21702c ISSN 2041-6520.
Wu, Kui, Hu, Wenbing, Luo, Qun, Li, Xianchan, Xiong, Shaoxiang, Sadler, P. J. and Wang, Fuyi (2013) Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry : ladder-sequencing versus top-down. Journal of The American Society for Mass Spectrometry, Volume 24 (Number 3). pp. 410-420. doi:10.1007/s13361-012-0539-z ISSN 1044-0305.
Barone, Carmen R., Coletti, Cecilia, McQuitty, Ruth J., Farrer, Nicola J., Lorusso, Giuseppe, Maresca, Luciana, Marrone, Alessandro, Natile, Giovanni, Pacifico, Concetta, Parsons, Simon, Re, Nazzareno, Sadler, P. J. and White, Fraser J. (2013) Photo-isomerisation of alkenyl complexes of platinum(ii) : structural, spectroscopic, kinetic and computational investigations. Dalton Transactions, Volume 42 (Number 19). pp. 6840-6851. doi:10.1039/c3dt32354d ISSN 1477-9226.
Pizarro, Ana M. and Sadler, P. J. (2013) Cancer chemistry : designing new drugs for cancer treatment. In: Pelengaris , Stella and Khan, Mike, (eds.) The molecular biology of cancer : a bridge from bench to bedside, 2nd Edition. Hoboken, NJ: Wiley-Blackwell. ISBN 9781118022870
Betanzos-Lara, Soledad, Habtemariam, Abraha and Sadler, P. J. (2013) Transfer hydrogenation reactions of photoactivatable N, N '-chelated ruthenium(II) arene complexes. Mexican Chemical Society Journal, Volume 57 (Number 3). pp. 160-168. ISSN 1870-249X.
Romero-CanelΓ³n, Isolda, Salassa, Luca and Sadler, P. J. (2013) The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway. Journal of Medicinal Chemistry, Volume 56 (Number 3). pp. 1291-1300. doi:10.1021/jm3017442 ISSN 0022-2623.
2012
Garino, Claudio, Gallo, Erik, Smolentsev, Nikolay, Glatzel, Pieter, Gobetto, Roberto, Lamberti, Carlo, Sadler, P. J. and Salassa, Luca (2012) Resonant X-ray emission spectroscopy reveals dβd ligand-field states involved in the self-assembly of a square-planar platinum complex. Physical Chemistry Chemical Physics, Vol.14 (No.44). pp. 15278-15281. doi:10.1039/c2cp42451g ISSN 1463-9076.
Zhao, Y., Roberts, Gareth M., Greenough, Simon E., Farrer, Nicola J., Peterson, Martin J. , Powell, William H., Stavros, Vasilios G. and Sadler, P. J. (2012) Two-photon-activated ligand exchange in platinum(II) complexes. Angewandte Chemie International Edition, Vol.51 (No.45). pp. 11263-11266. doi:10.1002/anie.201206283 ISSN 1521-3773.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, RΓΆmer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
BarragΓ‘n, Flavia, Carrion-Salip, Dolors, GΓ³mez-Pinto, Irene, GonzΓ‘lez-CantΓ³, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, GonzΓ‘lez, Carlos A., Massaguer, Anna and MarchΓ‘n, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
Soldevila-Barreda, Joan J., Bruijnincx, Pieter C. A., Habtemariam, Abraha, Clarkson, Guy J., Deeth, Robert J. and Sadler, P. J. (2012) Improved catalytic activity of rutheniumβarene complexes in the reduction of NAD+. Organometallics, Vol.31 (No.16). pp. 5958-5967. doi:10.1021/om3006307 ISSN 0276-7333.
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, SchΓΌnemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the βVenus flytrapβ cleft of FbpA : MΓΆssbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004 ISSN 0304-4165.
Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n ISSN 1520-5126.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanineβguanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Romero-CanelΓ³n, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Ragazzon, Giulio, Bratsos, Ioannis, Alessio, E. (Enzo), Salassa, Luca, Habtemariam, Abraha, McQuitty, Ruth J., Clarkson, Guy J. and Sadler, P. J. (2012) Design of photoactivatable metallodrugs : selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(NβNβ²)(py)]2+ complexes. Inorganica Chimica Acta, Vol.393 . pp. 230-238. doi:10.1016/j.ica.2012.06.031 ISSN 0020-1693.
Barry, Nicolas P. E. and Sadler, P. J. (2012) Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies. Chemical Society Reviews, Vol.41 (No.8). pp. 3264-3279. doi:10.1039/c2cs15300a ISSN 0306-0012.
Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y ISSN 0893-228X.
Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d ISSN 1756-5901.
Betanzos-Lara, Soledad, Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Qamar, Bushra and Sadler, P. J. (2012) Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. Angewandte Chemie International Edition, Vol.51 (No.16). pp. 3897-3900. doi:10.1002/anie.201108175 ISSN 1433-7851.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Westendorf, A. F., Woods, J. A., Korpis, K., Farrer, Nicola J., Salassa, Luca, Robinson, K., Appleyard, V., Murray, K., Grunert, R., Thompson, A. M., Sadler, P. J. and Bednarski, P. J. (2012) Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)] : a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics, Vol.11 (No.9). pp. 1894-1904. doi:10.1158/1535-7163.MCT-11-0959 ISSN 1535-7163.
Butler, Jennifer S. (Jennifer Suzanne), Woods, Julie A., Farrer, Nicola J., Newton, Mark E. and Sadler, P. J. (2012) Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society, Vol.134 (No.40). pp. 16508-16511. doi:10.1021/ja3074159 ISSN 0002-7863.
Ross, Allison, Choi, Jong-Ha, Hunter, Tina M., Pannecouque, Christophe, Moggach, Stephen A., Parsons, Simon, De Clercq, Erik and Sadler, P. J. (2012) Zinc(ii) complexes of constrained antiviral macrocycles. Dalton Transactions, Volume 41 (Number 21). pp. 6408-6418. doi:10.1039/c2dt30140g ISSN 1477-9226.
Tai, Hui-Chung, Zhao, Y., Farrer, Nicola J., Anastasi, Anna E., Clarkson, Guy J., Sadler, P. J. and Deeth, Robert J. (2012) A computational approach to tuning the photochemistry of platinum(IV) anticancer agents. Chemistry - A European Journal, Vol.18 (No.34). pp. 10630-10642. doi:10.1002/chem.201200782 ISSN 0947-6539.
Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d ISSN 2041-6520.
2011
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, LΓΌ, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide β a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409 ISSN 0947-6539.
Fu, Ying, Shnyder, Steve D., Habtemariam, Abraha, Clarkson, Guy J., Cooper, Patricia A., Loadman, Paul M., Pizarro, Ana M. and Sadler, P. J. (2011) Organometallic osmium arene anticancer complexes. In: 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, 28 Aug - 1 Sep 2011. Published in: American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.242 17-BIOL. ISSN 0065-7727.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d ISSN 1359-7345.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k ISSN 0003-2700.
Scotcher, Jenna, Clarke, D. J., Weidt, Stefan K., Mackay, C. Logan, Hupp, Theodore, Sadler, P. J. and Langridge-Smith, Pat R. R. (2011) Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.22 (No.5). pp. 888-897. doi:10.1007/s13361-011-0088-x ISSN 1044-0305.
Westendorf, Aron, Zerzankova, Lenka, Salassa, Luca, Sadler, P. J., Brabec, V. (Viktor) and Bednarski, Patrick J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, Vol.105 (No.5). pp. 652-662. doi:10.1016/j.jinorgbio.2011.01.003 ISSN 01620134.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Costantini, Giovanni, Scrivens, James H., Mukherjee, Arindam and Sadler, P. J. (2011) Human transferrin : association and fibril formation. American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.241 (No.171-BIOL ). ISSN 0065-7727
Ronconi, Luca and Sadler, P. J. (2011) Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions, Vol.40 (No.1). pp. 262-268. doi:10.1039/c0dt00546k ISSN 1477-9226.
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Farrer, Nicola J. and Sadler, P. J. (2011) Medicinal inorganic chemistry : state of the art, new trends, and a vision of the future. In: Alessio, E. (Enzo) , (ed.) Bioinorganic medicinal chemistry. Weinheim : Chichester: Wiley-VCH : John Wiley [distributor], pp. 1-48. ISBN 9783527326310
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
BarragΓ‘n, Flavia, LΓ³pez-SenΓn, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, P. J. and MarchΓ‘n, Vicente (2011) Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society, Vol.133 (No.35). pp. 14098-14108. doi:10.1021/ja205235m ISSN 0002-7863.
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, LΓΌ, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilideβa model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structureβactivity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e ISSN 1477-9226.
Li, Huilin, Lin, Tzu-Yung, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Barrow, Mark P., Pizarro, Ana M., Qi, Yulin, Sadler, P. J. and OβConnor, Peter B. (2011) Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry, Vol.83 (No.24). pp. 9507-9515. doi:10.1021/ac202267g ISSN 0003-2700.
2010
Salassa, Luca, Borfecchia, Elisa, Ruiu, Tiziana, Garino, Claudio, Gianolio, Diego, Gobetto, Roberto, Sadler, P. J., Cammarata, Marco, Wulff, Michael and Lamberti, Carlo (2010) Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry, Vol.49 (No.23). pp. 11240-11248. doi:10.1021/ic102021k ISSN 0020-1669.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399 ISSN 1433-7851.
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Williams, Jonathan P., Brown, Jeffery M., Campuzano, Iain and Sadler, P. J. (2010) Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chemical Communications, Vol.46 (No.30). pp. 5458-5460. doi:10.1039/c0cc00358a ISSN 1359-7345.
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Williams, Jonathan P., Phillips, Hazel I. A., Campuzano, Iain and Sadler, P. J. (2010) Shape changes induced by N-terminal platination of ubiquitin by cisplatin. Journal of The American Society for Mass Spectrometry, Vol.21 (No.7). pp. 1097-1106. doi:10.1016/j.jasms.2010.02.012 ISSN 1044-0305.
Novakova, Olga, Malina, J. (Jaroslav), Suchankova, Tereza, Kasparkova, Jana, Bugarcic, Tijana, Sadler, P. J. and Brabec, V. (Viktor) (2010) Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru-II complexes containing terphenyl arenes. Chemistry - A European Journal, Vol.16 (No.19). pp. 5744-5754. doi:10.1002/chem.200903078 ISSN 0947-6539.
Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496 ISSN 0947-6539.
Pizarro, Ana M., Melchart, Michael, Habtemariam, Abraha, Salassa, Luca, Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2010) Controlling the reactivity of ruthenium(II) arene complexes by tether ring-opening. Inorganic Chemistry, Vol.49 (No.7). pp. 3310-3319. doi:10.1021/ic902243q ISSN 0020-1669.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
Farrer, Nicola J., Woods, Julie A., Munk, Vivienne P., Mackay, Fiona S. and Sadler, P. J. (2010) Photocytotoxic trans-Diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology, Vol.23 (No.2). pp. 413-421. doi:10.1021/tx900372p ISSN 0893-228X.
Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u ISSN 0022-2623.
Bergamo, A., Masi, A., Peacock, Anna F. A., Habtemariam, Abraha, Sadler, P. J. and Sava, G. (2010) In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry, Vol.104 (No.1). pp. 79-86. doi:10.1016/j.jinorgbio.2009.10.005 ISSN 0162-0134.
Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2010) Activation mechanisms for organometallic anticancer complexes. In: Jaouen, GΓ©rard and Metzler-Nolte, Nils, (eds.) Medicinal organometallic chemistry. Topics in Organometallic Chemistry, Vol.32 . Berlin ; New York: Springer-Verlag, pp. 21-56. ISBN 9783642131844
Habtemariam, Abraha, Betanzos-Lara, Soledad and Sadler, P. J. (2010) Di-ΞΌ-chloro(ethylbenzoate)diruthenium(II) : [(Ξ·6-etb)RuCl2]2. In: Inorganic Syntheses. Inorganic Syntheses, Vol.35 . Hoboken, NJ: John Wiley & Sons, Inc., pp. 160-163. ISBN 9780471682554
Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578 ISSN 1565-3633.
Farrer, Nicola J., Monk , Nicholas, Heron, Jonathan, Lough, Julie Ann and Sadler, P. J. (2010) (RSC)(2) : chemistry, performance, and pedagogy - an interactive approach to periodic trends. Chemistry Education Research and Practice, Vol.11 (No.4). pp. 308-313. doi:10.1039/c0rp90011g ISSN 1109-4028.
2009
Rijt, Sabine H. van, Hebden, Andrew J., Amaresekera, Thakshila, Deeth, Robert J., Clarkson, Guy J., Parsons, S. (Simon), McGowan, Patrick C. and Sadler, P. J. (2009) Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes. Journal of Medicinal Chemistry, Vol.52 (No.23). pp. 7753-7764. doi:10.1021/jm900731j ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Salassa, Luca, Phillips, Hazel I. A. and Sadler, P. J. (2009) Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N-3)(2)(OH)(2)(NH3)(2)] : insights from DFT calculations. Physical Chemistry Chemical Physics, Vol.11 (No.44). pp. 10311-10316. doi:10.1039/b912496a ISSN 1463-9076.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
Stewart, Alan J., Blindauer, Claudia A. and Sadler, P. J. (2009) Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein. Biochimie, Vol.91 (No.11-12). pp. 1518-1522. doi:10.1016/j.biochi.2009.08.002 ISSN 0300-9084.
Williams, Jonathan P., Lough, Julie Ann, Campuzano, Iain, Richardson, K. (Keith) and Sadler, P. J. (2009) Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Communications in Mass Spectrometry, Vol.23 (No.22). pp. 3563-3569. doi:10.1002/rcm.4285 ISSN 09514198.
Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366 ISSN 0020-1669.
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
Newstead, Simon, Fowler, Philip W., Bilton, Paul R., Carpenter, Elisabeth P., Sadler, P. J., Campopiano, Dominic J., Sansom, M. S. P. (Mark S. P.) and Iwata, So (2009) Insights into how nucleotide-binding domains power ABC transport. Structure, Vol.17 (NO.9). pp. 1213-1222. doi:10.1016/j.str.2009.07.009 ISSN 0969-2126.
Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g ISSN 1477-9226.
Wang, Fuyi, Habtemariam, Abraha, van der Geer, Erwin P. L., Deeth, Robert J., Gould, Robert O., Parsons, Simon and Sadler, P. J. (2009) Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry, Vol.14 (No.7). pp. 1065-1076. doi:10.1007/s00775-009-0549-x ISSN 0949-8257.
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
Hu, Wenbing, Luo, Qun, Ma, Xiaoyan, Wu, Kui, Liu, Jianan, Chen, Yi, Xiong, Shaoxiang, Wang, Jianping, Sadler, P. J. and Wang, Fuyi (2009) Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry - A European Journal, Vol.15 (No.27). pp. 6586-6594. doi:10.1002/chem.200900699 ISSN 0947-6539.
Williams, Jonathan P., Bugarcic, Tijana, Habtemariam, Abraha, Giles, K. (Kevin), Campuzano, Iain, Rodger, P. Mark and Sadler, P. J. (2009) Isomer separation and gas-phase configurations of organoruthenium anticancer complexes : ion mobility mass spectrometry and modeling. Journal of The American Society for Mass Spectrometry, Vol.20 (No.6). pp. 1119-1122. doi:10.1016/j.jasms.2009.02.016 ISSN 1044-0305.
Gray, Jennifer C., Pagelot, Alain, Collins, Anna, Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) and ruthenium(II) biphenyl sandwich complexes : x-ray crystal structures and Os-187 NMR spectroscopic studies in solution. European Journal of Inorganic Chemistry, Vol.2009 (No.18). pp. 2673-2677. doi:10.1002/ejic.200900244 ISSN 1434-1948.
Diakos, Connie I., Messerle, Barbara A., del Socorro Murdoch, P., Parkinson, J. A. (John A.), Sadler, P. J., Fenton, Ronald R. and Hambley, Trevor W. (2009) Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz=3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, Vol.48 (No.7). pp. 3047-3056. doi:10.1021/ic802207m ISSN 0020-1669.
Sadler, P. J. (2009) Precious anticancer drugs. Chemistry & Industry (No.5). pp. 18-20. ISSN 0009-3068.
Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. doi:10.1016/j.ica.2008.02.039 ISSN 0020-1693.
Salassa, Luca, Garino, Claudio, Salassa, Giovanni, Nervi, Carlo, Gobetto, Roberto, Lamberti, Carlo, Gianolio, Diego, Bizzarri, Ranieri and Sadler, P. J. (2009) Ligand-selective photodissociation from [Ru(bpy)(4AP)(4)](2+) : a spectroscopic and computational study. Inorganic Chemistry, Vol.48 (No.4). pp. 1469-1481. doi:10.1021/ic8015436 ISSN 0020-1669.
Rijt, Sabine H. van, Peacock, Anna F. A., Johnstone, Russell D. L., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry, Vol.48 (No.4). pp. 1753-1762. doi:10.1021/ic8020222 ISSN 0020-1669.
Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206 ISSN 0947-6539.
Sadler, P. J. (2009) Protein recognition of platinated DNA. ChemBioChem, Vol.10 (No.1). pp. 73-74. ISSN 1439-4227 doi:10.1002/cbic.200800733
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Sadler, P. J. (2009) Dalton Transactions themed issue on Metal Anticancer Compounds. Dalton Transactions (No.48). p. 10647. ISSN 1477-9226 doi:10.1039/b923498p
Pizarro, Ana M. and Sadler, P. J. (2009) Metal ionβnucleic acid interactions in disease and medicine. In: Hud, Nicholas V. (Nicholas Vincent), (ed.) Nucleic Acid-Metal Ion Interactions. RSC biomolecular sciences . Cambridge, UK: Royal Society of Chemistry, pp. 350-416. ISBN 9780854041954
Rijt, Sabine H. van, Peacock, Anna F. A. and Sadler, P. J. (2009) Osmium arenes : a new class of potential anti-cancer agents. In: Bonetti, Andrea, MD and Leone, Roberto and Muggia, Franco M. and Howell, Stephen B., 1944-, (eds.) Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications. Cancer drug discovery and development . Totowa, N.J. : London: Humana : Springer [distributor], pp. 73-79. ISBN 978-1-60327-458-6
Farrer, Nicola J., Salassa, Luca and Sadler, P. J. (2009) Photoactivated chemotherapy (PACT) : the potential of excited-state d-block metals in medicine. Dalton Transactions, Vol.48 . pp. 10690-10701. doi:10.1039/b917753a ISSN 1477-9226.
Salassa, Luca, Gianolio, Diego, Garino, Claudio, Salassa, Giovanni, Borfecchia, Elisa, Ruiu, Tiziana, Nervi, Carlo, Gobetto, Roberto, Bizzarri, Ranieri, Sadler, P. J. and Lamberti, Carlo (2009) Structure of [Ru(bpy)(n)(AP)((6-2n))](2+) homogeneous complexes: DFT calculation vs. EXAFS. In: 14th International Conference on X-Ray Absorption Fine Structure (XAFS14), Camerino, Italy, July 26-31, 2009. Published in: Journal of Physics: Conference Series, Vol.190 Article no. 012141. ISBN *****************. doi:10.1088/1742-6596/190/1/012141 ISSN 1742-6596.
2008
Bugarcic, Tijana, Habtemariam, Abraha, Stepankova, Jana, Heringova, Pavla, Kasparkova, Jana, Deeth, Robert J., Johnstone, Russell D. L., Prescimone, Alessandro, Parkin, Andrew, Parsons, S. (Simon), Brabec, V. (Viktor) and Sadler, P. J. (2008) The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry, Vol.47 (No.24). pp. 11470-11486. doi:10.1021/ic801361m ISSN 0020-1669.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Peacock, Anna F. A. and Sadler, P. J. (2008) Medicinal organometallic chemistry : designing metal arene complexes as anticancer agents. Chemistry - An Asian Journal, Vol.3 (No.11). pp. 1890-1899. ISSN 1861-4728 doi:10.1002/asia.200800149
Ronconi, Luca and Sadler, P. J. (2008) Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews, Vol.252 (No.21-22). pp. 2239-2277. ISSN 0010-8545 doi:10.1016/j.ccr.2008.01.016
Petzold, Holm and Sadler, P. J. (2008) Oxidation induced by the antioxidant glutathione (GSH). Chemical Communications (No.37). pp. 4413-4415. doi:10.1039/b805358h ISSN 1359-7345.
Bugarcic, Tijana, Novakova, Olga, Halamikova, Anna, Zerzankova, Lenka, Vrana, Oldrich, Kasparkova, Jana, Habtemariam, Abraha, Parsons, S. (Simon), Sadler, P. J. and Brabec, V. (Viktor) (2008) Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry, Vol.51 (No.17). pp. 5310-5319. doi:10.1021/jm8003043 ISSN 0022-2623.
Gray, Jennifer C., Habtemariam, Abraha, Winnig, Marcel, Meyerhof, Wolfgang and Sadler, P. J. (2008) Sweetening ruthenium and osmium : organometallic arene complexes containing aspartame. Journal of Biological Inorganic Chemistry, Vol.13 (No.7). pp. 1111-1120. doi:10.1007/s00775-008-0396-1 ISSN 0949-8257.
Dougan, Sarah J., Habtemariam, Abraha, McHale, Sarah E., Parsons, S. (Simon) and Sadler, P. J. (2008) Catalytic organometallic anticancer complexes. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.33). pp. 11628-11633. doi:10.1073/pnas.0800076105 ISSN 0027-8424.
Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3 ISSN 0949-8257.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
Euser, T. G., Chen, J. S. Y., Scharrer, M., Russell, Philip St. J., Farrer, Nicola J. and Sadler, P. J. (2008) Quantitative broadband chemical sensing in air-suspended solid-core fibers. Journal of Applied Physics, Vol.103 (No.10). p. 103108. doi:10.1063/1.2924408 ISSN 0021-8979.
Blindauer, Claudia A., Harrison, Mark D., Parkinson, J. A. (John A.), Robinson, N. J. (Nigel J.) and Sadler, P. J. (2008) Isostructural replacement of zinc by cadmium in bacterial metallothionein. In: 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, France, 19-22 May 2008. Published in: Metal Ions in Biology and Medicine, Vol.10 pp. 167-173. ISBN 978-2-7420-0714-1. ISSN 1257-2535.
Petzold, Holm, Xu, Jingjing and Sadler, P. J. (2008) Metal and ligand control of sulfenate reactivity : arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie International Edition, Vol.47 (No.16). pp. 3008-3011. doi:10.1002/anie.200705342 ISSN 1433-7851.
Wang, Fuyi, Weidt, Stefan, Xu, Jingjing, Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 18O-labeling. Journal of The American Society for Mass Spectrometry, Vol.19 (No.4). pp. 544-549. doi:10.1016/j.jasms.2007.12.002 ISSN 1044-0305.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Ghosh, Surajit, Mukherjee, Arindam, Sadler, P. J. and Verma, Sandeep (2008) Periodic iron nanomineralization in human serum transferrin fibrils. Angewandte Chemie International Edition, Vol.47 (No.12). pp. 2217-2221. doi:10.1002/anie.200705723 ISSN 1433-7851.
Ronconi, Luca and Sadler, P. J. (2008) Unprecedented carbonβcarbon bond formation induced by photoactivation of a platinum(iv)-diazido complex. Chemical Communications (2). pp. 235-237. doi:10.1039/b714216a ISSN 1359-7345.
Farrer, Nicola J. and Sadler, P. J. (2008) Photochemotherapy : targeted activation of metal anticancer complexes. Australian Journal of Chemistry, Vol.61 (No.9). pp. 669-674. doi:10.1071/CH08088 ISSN 0004-9425.
2007
Mackay, Fiona S., Woods, Julie A., Heringova, Pavia, Kasparkova, Jana, Pizarro, Ana M., Moggach, Stephen A., Parsons, Simon, Brabec, V. (Viktor) and Sadler, P. J. (2007) A potent cytotoxic photoactivated platinum complex. Proceedings of the National Academy of Sciences of the United States of America, Vol.104 (No.52). pp. 20743-20748. doi:10.1073/pnas.0707742105 ISSN 0027-8424.
Melchart, Michael, Habtemariam, Abraha, Novakova, Olga, Moggach, Stephen A., Fabbiani, Francesca P. A., Parsons, Simon, Brabec, V. (Viktor) and Sadler, P. J. (2007) Bifunctional amine-tethered Ruthenium(II) arene complexes form monofunctional adducts on DNA. Inorganic Chemistry, Vol.46 (No.21). pp. 8950-8962. doi:10.1021/ic700799w ISSN 0020-1669.
Dougan, Sarah J., Mukherjee, Arindam, Habtemariam, Abraha and Sadler, P. J. (2007) INOR 147-Kinetically-inert organometallic ruthenium arene complexes: A new class of cancer cell cytotoxic agents. In: UNSPECIFIED. Published in: Abstracts of papers of the American Chemical Society, Vol.234 ISSN 0065-7727.
Blindauer, Claudia A., Razi, M. Tahir, Campopiano, Dominic J. and Sadler, P. J. (2007) Histidine ligands in bacterial metallothionein enhance cluster stability. Journal of Biological Inorganic Chemistry, Vol.12 (No.3). pp. 393-405. doi:10.1007/s00775-006-0196-4 ISSN 0949-8257.
Peacock, Anna F. A., Melchart, Michael, Deeth, Robert J., Habtemariam, Abraha, Parsons, Simon and Sadler, P. J. (2007) Osmium(II) and ruthenium(II) arene maltolato complexes : rapid hydrolysis and nucleobase binding. Chemistry : A European Journal, Volume 13 (Number 9). pp. 2601-2613. doi:10.1002/chem.200601152 ISSN 0947-6539.
Dougan, Sarah J. and Sadler, P. J. (2007) The design of organometallic ruthenium arene anticancer agents. Chimia, Volume 61 (Number 11). pp. 704-715. doi:10.2533/chimia.2007.704 ISSN 0009-4293.
2006
Habtemariam, Abraha, Melchart, Michael, FernΓ‘ndez, Rafael, Parsons, Simon, Oswald, Iain D. H., Parkin, Andrew, Fabbiani, Francesca P. A., Davidson, James E., Dawson, Alice, Aird, Rhona E., Jodrell, Duncan I. and Sadler, P. J. (2006) Structureβactivity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry, Volume 49 (Number 23). pp. 6858-6868. doi:10.1021/jm060596m ISSN 0022-2623.
2005
Wang, Fuyi, Xu, Jingjing, Habtemariam, Abraha, Bella, Juraj and Sadler, P. J. (2005) Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex : detection of a sulfenato intermediate. Journal of the American Chemical Society, Volume 127 (Number 50). pp. 17734-17743. doi:10.1021/ja053387k ISSN 0002-7863.
2002
Liang, Xiangyang, Parkinson, J. A. (John A.), WeishΓ€upl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
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