2020

Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Biotinylated photoactive Pt(IV) anticancer complexes. Chemical Communications, 56 (15). pp. 2320-2323. doi:10.1039/c9cc07845b

Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Data for Biotinylated photoactive Pt(IV) anticancer complexes. [Dataset]

Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, Vindy Tjendana, Sadler, Peter J., Telling, Neil D. and Collingwood, Joanna F. (2020) Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. Journal of Trace Elements in Medicine and Biology . 126555. doi:10.1016/j.jtemb.2020.126555 (In Press)

Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, V., Banerjee, Samya, O’Connor, Peter B., Morrison, C., Sadler, P. J., Telling, Neil D. and Collingwood, Joanna F. (2020) Label-free nano-imaging of neuromelanin in Parkinson’s disease cases using soft x-ray spectromicroscopy. Angewandte Chemie (International Edition) . doi:10.1002/anie.202000239 (In Press)

2019

Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng, Habtemariam, Abraha and Sadler, Peter J. (2019) ‘Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta . 119396. doi:10.1016/j.ica.2019.119396 (In Press)

Zhang, Wen-Ying, Bridgewater, Hannah E., Banerjee, Samya, Soldevila-Barreda, Joan J., Clarkson, Guy J., Shi, Huayun, Imberti, Cinzia and Sadler, Peter J. (2019) Ligand-controlled reactivity and cytotoxicity of cyclometalated rhodium(III) complexes. European Journal of Inorganic Chemistry . doi:10.1002/ejic.201901055

Huang, Huaiyi, Banerjee, Samya, Qiu, Kangqiang, Zhang, Pingyu, Blacque, Olivier, Malcomson, Thomas, Paterson, Martin J., Clarkson, Guy J., Staniforth, Michael, Stavros, Vasilios G., Gasser, Gilles, Chao, Hui and Sadler, Peter J. (2019) Targeted photoredox catalysis in cancer cells. Nature Chemistry, 11 . pp. 1041-1048. doi:10.1038/s41557-019-0328-4

Lermyte, Frederik, Everett, James, Brooks, Jake, Bellingeri, Francesca, Billimoria, Kharmen, Sadler, Peter J., O’Connor, Peter B., Telling, Neil D. and Collingwood, Joanna F. (2019) Emerging approaches to investigate the influence of transition metals in the proteinopathies. Cells, 8 (10). 1231. doi:10.3390/cells8101231

Lermyte, Frederik, Everett, James, Lam, Yuko P. Y., Wootton, Christopher, Brooks, Jake, Barrow, Mark P., Telling, Neil D., Sadler, P. J., O'Connor, Peter B. and Collingwood, Joanna F. (2019) Data for Metal ion binding to the amyloid beta monomer studied by native top-down FTICR mass spectrometry. [Dataset]

Lermyte, Frederik, Everett, James, Lam, Yuko P. Y., Wootton, Christopher, Brooks, Jake, Barrow, Mark P., Telling, Neil D., Sadler, P. J., O'Connor, Peter B. and Collingwood, Joanna F. (2019) Metal ion binding to the amyloid beta monomer studied by native top-down FTICR mass spectrometry. Journal of The American Society for Mass Spectrometry, 30 (10). pp. 2123-2134. doi:10.1007/s13361-019-02283-7

Shi, Huayun, Wang, Qian, Venkatesh, Venkatesh, Feng, Guokai, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng and Sadler, P. J. (2019) Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide. Dalton Transactions . doi:10.1039/c9dt00909d (In Press)

Shi, Huayun, Imberti, Cinzia and Sadler, P. J. (2019) Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy. Inorganic Chemistry Frontiers . doi:10.1039/c9qi00288j (In Press)

Banerjee, Samya, Capper, Miles S., Clarkson, Guy J., Huang, Huaiyi and Sadler, Peter J. (2019) Dual-action platinum(II) Schiff base complexes : photocytotoxicity and cellular imaging. Polyhedron . doi:10.1016/j.poly.2019.04.024 (In Press)

Banerjee, Samya, Omlor, Andreas, Wolny, Juliusz A., Han, Yisong, Lermyte, Frederik, Godfrey, Amy, O'Connor, Peter B., Schünemann, Volker, Danaie, Mohsen and Sadler, Peter J. (2019) Generation of maghemite nanocrystals from iron–sulfur centres. Dalton Transactions . doi:10.1039/C9DT00514E (In Press)

Shi, Huayun, Clarkson, Guy J. and Sadler, Peter J. (2019) Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands. Inorganica Chimica Acta, 489 . pp. 230-235. doi:10.1016/j.ica.2019.02.016 (In Press)

Zhang, Pingyu, Huang, Huaiyi, Banerjee, Samya, Clarkson, Guy J., Ge, Chen, Imberti, Cinzia and Sadler, Peter J. (2019) Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy. Angewandte Chemie International Edition, 58 (8). pp. 2350-2354. doi:10.1002/anie.201813002

Gondim, Ana C. S., Roberta da Silva, Suzete, Mathys, Leen, Noppen, Sam, Liekens, Sandra, Holanda Sampaio, Alexandre, Nagano, Celso S., Renata Costa Rocha, Cintia, Nascimento, Kyria S., Cavada, Benildo S., Sadler, Peter J. and Balzarini, Jan (2019) Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity. MedChemComm, 10 (3). pp. 390-398. doi:10.1039/c8md00508g

Wootton, Christopher, Millett, Adam J., Lopez-Clavijo, Andrea F., Chiu, Cookson, Barrow, Mark P., Clarkson, Guy J., Sadler, P. J. and O'Connor, Peter B. (2019) Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. Analyst . doi:10.1039/C8AN02094A (In Press)

2018

Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16). pp. 7330-7344. doi:10.1021/acs.jmedchem.8b00906

Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Data for Biguanide iridium(III) complexes with potent antimicrobial activity. [Dataset]

Farrer, Nicola J., Sharma, Gitanjali, Sayers, Rachel, Shaili, Evyenia and Sadler, P. J. (2018) Platinum(iv) azido complexes undergo copper-free click reactions with alkynes. Dalton Transactions, 47 (31). pp. 10553-10560. doi:10.1039/c7dt04183g

Sanchez-Cano, Carlos, Romero-Canelón, Isolda, Geraki, Kalotina and Sadler, Peter J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014

Huang, Huaiyi, Banerjee, Samya and Sadler, Peter J. (2018) Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy. Chembiochem, 19 (15). pp. 1574-1589. doi:10.1002/cbic.201800182

Martin, Esther M., Kondrat, Frances D. L., Stewart, Alan J., Scrivens, James H., Sadler, P. J. and Blindauer, Claudia A. (2018) Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein. Scientific Reports, 8 (1). 8646. doi:10.1038/s41598-018-26924-1

Gothe, Yvonne, Romero-Canelón, Isolda, Marzo, Tiziano, Sadler, P. J., Messori, Luigi and Metzler-Nolte, Nils (2018) Synthesis and mode of action studies on Iridium(I)-NHC anticancer drug candidates. European Journal of Inorganic Chemistry . doi:10.1002/ejic.201800225 (In Press)

Sanchez-Cano, Carlos, Romero-Canelón, Isolda, Gerakic, Kalotina and Sadler, P. J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex. Journal of Inorganic Biochemistry . doi:10.1016/j.jinorgbio.2018.04.014 (In Press)

Chen, Feng, Romero-Canelón, Isolda, Soldevila-Barreda, Joan J., Song, Ji-Inn, Coverdale, James P. C., Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Wills, Martin, Brabec, Viktor and Sadler, P. J. (2018) Transfer hydrogenation and antiproliferative activity of tethered half-sandwich organoruthenium catalysts. Organometallics, 37 (10). pp. 1555-1566. doi:10.1021/acs.organomet.8b00132

Chen, Feng, Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Coverdale, James P. C., Song, Ji-Inn, Clarkson, Guy J., Kasparkova, Jana, Habtemariam, Abraha, Brabec, Viktor, Wolny, Juliusz A., Schünemann, Volker and Sadler, P. J. (2018) Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate. Dalton Transactions, 47 (21). 7178-7189 . doi:10.1039/C8DT00438B

Chellan , Prinessa, Avery, Vicky M., Duffy, Sandra, Triccas, James A., Nagalingam, Gayathri, Tam, Christina, Cheng, Luisa W., Liu, Jenny, Land, Kirkwood M., Clarkson, Guy J., Romero-Canelón, Isolda and Sadler, Peter J. (2018) Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance. Chemistry - A European Journal, 24 (40). pp. 10078-10090. doi:10.1002/chem.201801090

Banerjee, Samya, Soldevila-Barreda, Joan J., Wolny, Juliusz A., Wootton, Christopher, Habtemariam, Abraha, Romero-Canelón, Isolda, Chen, Feng, Clarkson, Guy J., Prokes, Ivan, Song, Lijiang, O'Connor, Peter B., Schünemann, Volker and Sadler, P. J. (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science, 9 (12). pp. 3177-3185. doi:10.1039/c7sc05058e

Gatti, Anna, Habtemariam, Abraha, Romero-Canelón, Isolda, Song, Ji-Inn, Heer, Bindy, Clarkson, Guy J., Rogolino, Dominga, Sadler, P. J. and Carcelli, Mauro (2018) Half-sandwich arene ruthenium(II) and osmium(II) thiosemicarbazone complexes : solution behavior and antiproliferative activity. Organometallics, 37 (6). pp. 891-899. doi:10.1021/acs.organomet.7b00875

Wootton, Christopher, Sanchez-Cano, Carlos, Lopez-Clavijo, Andrea F., Shaili, Evyenia, Barrow, Mark P., Sadler, P. J. and O'Connor, Peter B. (2018) Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes. Chemical Science, 9 . pp. 2733-2739. doi:10.1039/C7SC05135B

Coverdale, James P. C., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Clarkson, Guy J., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2018) Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells. Nature Chemistry, 10 . pp. 347-354. doi:10.1038_nchem.2918

Larnaudie, Sophie, Brendel, Johannes C., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Catrouillet, Sylvain, Sanchis, Joaquin, Coverdale, James P. C., Song, Ji-Inn, Habtemariam, Abraha, Sadler, P. J., Jolliffe, Katrina A. and Perrier, Sébastien (2018) Cyclic peptide–polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes. Biomacromolecules, 19 (1). pp. 239-247. doi:10.1021/acs.biomac.7b01491

Sadler, P. J., Vernooij, Robbin, Joshi, Tanmaya, Horbury, Michael D., Graham, Bim, Izgorodina, Ekaterina I., Stavros, Vasilios G., Spiccia, Leone and Wood, Bayden R. (2018) Spectroscopic studies on photoinduced reactions of the anticancer prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]. Chemistry - A European Journal . doi:10.1002/chem.201705349 (In Press)

Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, V., Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, Peter J. (2018) Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs. [Dataset]

Hearn, Jessica M., Hughes, George Marc, Romero-Canelón, Isolda, Munro, Alison F., Rubio-Ruiz, Belén, Liu, Zhe, Carragher, Neil O. and Sadler, P. J. (2018) Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Metallomics, 10 (1). 93-107 . doi:10.1039/C7MT00242D

Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, Venkatesh, Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, P. J. (2018) Photoactivatable cell-selective dinuclear trans diazido platinum(IV) anticancer prodrugs. Inorganic Chemistry . doi:10.1021/acs.inorgchem.8b02599 (In Press)

Venkatesh, Venkatesh and Sadler, P. J. (2018) Platinum(IV) prodrugs. In: Sigel, Astrid and Sigel, Helmut and Freisinger, Eva and Sigel, Roland K.O., (eds.) Metallo-Drugs: Development and Action of Anticancer Agents. Metal Ions in Life Sciences, 18 . De Gruyter, pp. 69-108. ISBN 9783110470734

2017

Zhang, Pingyu, Chiu, Cookson K. C., Huang, Huayi, Lam, Yuko P. Y., Habtemariam, Abraha, Malcomson, Thomas, Paterson, Martin J., Clarkson, Guy J., O'Connor, Peter B., Chao, Hui and Sadler, P. J. (2017) Organoiridium photosensitizers induce specific oxidative attack on proteins within cancer cells. Angewandte Chemie International Edition, 56 (47). pp. 14898-14902. doi:10.1002/anie.201709082

Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014

Gondim, Ana C. S., Romero-Canelón, Isolda, Sousa, Eduardo H.S., Blindauer, Claudia A., Butler, Jennifer S., Romero, Maria, Sanchez-Cano, Carlos, Sousa, Bruno L., Chaves, Renata P., Nagano, Celso S., Cavada, Benildo S. and Sadler, P. J. (2017) The potent anti-cancer activity of Dioclea lasiocarpa lectin. Journal of Inorganic Biochemistry, 175 . pp. 179-189. doi:10.1016/j.jinorgbio.2017.07.011

McQuitty, Ruth J., Unterkofler, Sarah, Euser, Tijmen G., Russell, Philip St. J. and Sadler, P. J. (2017) Rapid screening of photoactivatable metallodrugs : photonic crystal fibre microflow reactor coupled to ESI mass spectrometry. RSC Advances , 7 (59). pp. 37340-37348. doi:10.1039/c7ra06735f

Zhang, Pingyu and Sadler, Peter J. (2017) Advances in the design of organometallic anticancer complexes. Journal of Organometallic Chemistry, 839 . pp. 5-14. doi:10.1016/j.jorganchem.2017.03.038

Sadler, Peter J. (2017) Biosketch of Peter J. Sadler. Journal of Organometallic Chemistry, 839 . pp. 2-4. doi:10.1016/j.jorganchem.2017.04.020

Venkatesh, Venkatesh, Mishra, Narendra, Romero-Canelón, Isolda, Vernooij, Robbin, Shi, Huayun, Coverdale, James P. C., Habtemariam, Abraha, Verma, Sandeep and Sadler, P. J. (2017) Supramolecular photoactivatable anticancer hydrogels. Journal of the American Chemical Society, 139 (16). pp. 5656-5659. doi:10.1021/jacs.7b00186

Needham, Russell J., Sanchez-Cano, Carlos, Zhang, Xin, Romero-Canelón, Isolda, Habtemariam, Abraha, Cooper, Margaret S., Meszaros, Levente, Clarkson, Guy J., Blower, Philip J. and Sadler, P. J. (2017) In-cell activation of organo-osmium(II) anticancer complexes. Angewandte Chemie International Edition, 56 (4). pp. 1017-1020. doi:10.1002/anie.201610290

Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014

Venkatesh, Venkatesh, Berrocal-Martin, Raul, Wedge, Christopher, Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Song, Ji-Inn, Coverdale, James P. C., Zhang, Pingyu, Clarkson, Guy J., Habtemariam, Abraha, Magennis, Steven W., Deeth, Robert J. and Sadler, P. J. (2017) Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes. Chemical Science, 8 (12). pp. 8271-8278. doi:10.1039/C7SC03216A

2016

Liu, Hong-Ke, Kostrhunova, Hana, Habtemariam, Abraha, Kong, Yaqiong, Deeth, Robert J., Brabec, Viktor and Sadler, P. J. (2016) "Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes. Dalton Transactions, 45 . pp. 18676-18688. doi:10.1039/c6dt03356c

Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995

Ude, Ziga, Romero-Canelón, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018

Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f

Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions, 45 . pp. 13034-13037. doi:10.1039/C6DT01382A

Vernooij, Robbin, Joshi, Tanmaya, Shaili, Evyenia, Kubeil, Manja, Appadoo, Dominique R. T., Izgorodina, Ekaterina I., Graham, Bim, Sadler, P. J., Wood, Bayden R. and Spiccia, Leone (2016) Data for Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. [Dataset]

Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Data for Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex. [Dataset]

Pitto-Barry, Anaïs, Sadler, P. J. and Barry, Nicolas P. E. (2016) Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications, 52 (20). pp. 3895-3898. c5cc09564f. doi:10.1039/c5cc09564f

Vernooij, Robbin, Joshi, Tanmaya, Shaili, Evyenia, Kubeil, Manja, Appadoo, Dominique R. T., Izgorodina, Ekaterina I., Graham, Bim, Sadler, P. J., Wood, Bayden R. and Spiccia, Leone (2016) Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. Inorganic Chemistry, 55 (12). pp. 5983-5992. doi:10.1021/acs.inorgchem.6b00476

Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075

Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A

Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222

2015

Soldevila-Barreda, Joan J., Habtemariam, Abraha, Romero-Canelón, Isolda and Sadler, P, J. (2015) Half-sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry, 153 . pp. 322-333. doi:10.1016/j.jinorgbio.2015.10.008

Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011

Pitto-Barry, Anaïs, Alves Perdigão, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a

Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655

Zou, Taotao and Sadler, P. J. (2015) Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today : Technologies, 16 . pp. 7-15. doi:10.1016/j.ddtec.2015.08.002

Barry, Nicolas P. E., Pitto-Barry, Anaïs, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., O’Reilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853

Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097

Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534

Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582

Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182

Wootton, Christopher, Sanchez-Cano, Carlos, Liu, Hong, Barrow, Mark P., Sadler, P. J. and O'Connor, Peter B. (2015) Binding of an organo–osmium(ii) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top–Down FT-ICR mass spectrometry. Dalton Transactions, 44 (8). pp. 3624-3632. doi:10.1039/C4DT03819C

Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024

2014

Sousa, Eduardo Henrique Silva, de Mesquita Vieira, Francisca Gilmara, Butler, Jennifer S. (Jennifer Suzanne), Basso, Luiz Augusto, Santiago, Diógenes S., Diógenes, Izaura C.N., Lopes, Luiz Gonzaga de França and Sadler, P. J. (2014) [Fe(CN)5(isoniazid)]3−: an iron isoniazid complex with redox behavior implicated in tuberculosis therapy. Journal of Inorganic Biochemistry, Volume 140 . pp. 236-244. doi:10.1016/j.jinorgbio.2014.08.002

Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f

Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f

Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0

Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851

Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j

Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c

Barry, Nicolas P. E., Kemp, Thomas F., Sadler, P. J. and Hanna, John V. (2014) A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes. Dalton Transactions, Volume 43 (Number 13). pp. 4945-4949. doi:10.1039/c3dt53589d

Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161

2013

Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505

Barry, Nicolas P. E., Deeth, Robert J., Clarkson, Guy J., Prokes, Ivan and Sadler, P. J. (2013) Thermochromic organometallic complexes: experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(ii) carboranes with aromatic amine ligands. Dalton Transactions, Volume 42 (Number 7). pp. 2580-2587. doi:10.1039/c2dt32650g

Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028

Lin, Yu, Huang, Yongdong, Zheng, Wei, Wang, Fuyi, Habtemariam, Abraha, Luo, Qun, Li, Xianchan, Wu, Kui, Sadler, P. J. and Xiong, Shaoxiang (2013) Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π. Journal of Inorganic Biochemistry, Volume 128 . pp. 77-84. doi:10.1016/j.jinorgbio.2013.07.029

Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183

Wang, Fuyi, Xu, Jingjing, Wu, Kui, Weidt, Stefan K., Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2013) Competition between glutathione and DNA oligonucleotides for ruthenium(ii) arene anticancer complexes. Dalton Transactions, Volume 42 (Number 9). pp. 3188-3195. doi:10.1039/c2dt32091f

Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519

Barry, Nicolas P. E. and Sadler, P. J. (2013) Challenges for metals in medicine : how nanotechnology may help to shape the future. ACS Nano, Volume 7 (Number 7). pp. 5654-5659. doi:10.1021/nn403220e

Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374

Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a

Cubillas, Ana M., Unterkofler, Sarah, Euser, Tijmen G., Etzold, Bastian J. M., Jones, Anita C., Sadler, P. J., Wasserscheid, Peter and Russell, Philip St.J. (2013) Photonic crystal fibres for chemical sensing and photochemistry. Chemical Society Reviews . doi:10.1039/c3cs60128e

Barry, Nicolas P. E. and Sadler, P. J. (2013) Exploration of the medical periodic table : towards new targets. Chemical Communications, Volume 49 (Number 45). pp. 5106-5131. doi:10.1039/c3cc41143e

Borfecchia, Elisa, Garino, Claudio, Salassa, Luca, Ruiu, Tiziana, Gianolio, Diego, Zhang, Xiaoyi, Attenkofer, Klaus, Chen, Lin X., Gobetto, Roberto, Sadler, P. J. and Lamberti, Carlo (2013) X-ray transient absorption structural characterization of the 3MLCT triplet excited state of cis-[Ru(bpy)2(py)2]2+. Dalton Transactions, Volume 42 (Number 18). pp. 6564-6571. doi:10.1039/c3dt32865a

Liu, Zhe , Deeth, Robert J., Butler, Jennifer S. (Jennifer Suzanne), Habtemariam, Abraha, Newton, Mark E. and Sadler, P. J. (2013) Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie International Edition, Volume 52 (Number 15). pp. 4194-4197. doi:10.1002/anie.201300747

Butler, Jennifer S. (Jennifer Suzanne) and Sadler, P. J. (2013) Targeted delivery of platinum-based anticancer complexes. Current Opinion in Chemical Biology, Volume 17 (Number 2). pp. 175-188. doi:10.1016/j.cbpa.2013.01.004

Scotcher, Jenna, Clarke, David J., Mackay, C. Logan, Hupp, Ted R., Sadler, P. J. and Langridge-Smith, Pat R. R. (2013) Redox regulation of tumour suppressor protein p53 : identification of the sites of hydrogen peroxide oxidation and glutathionylation. Chemical Science, Volume 4 (Number 3). pp. 1257-1269. doi:10.1039/c2sc21702c

Wu, Kui, Hu, Wenbing, Luo, Qun, Li, Xianchan, Xiong, Shaoxiang, Sadler, P. J. and Wang, Fuyi (2013) Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry : ladder-sequencing versus top-down. Journal of The American Society for Mass Spectrometry, Volume 24 (Number 3). pp. 410-420. doi:10.1007/s13361-012-0539-z

Barone, Carmen R., Coletti, Cecilia, McQuitty, Ruth J., Farrer, Nicola J., Lorusso, Giuseppe, Maresca, Luciana, Marrone, Alessandro, Natile, Giovanni, Pacifico, Concetta, Parsons, Simon, Re, Nazzareno, Sadler, P. J. and White, Fraser J. (2013) Photo-isomerisation of alkenyl complexes of platinum(ii) : structural, spectroscopic, kinetic and computational investigations. Dalton Transactions, Volume 42 (Number 19). pp. 6840-6851. doi:10.1039/c3dt32354d

Pizarro, Ana M. and Sadler, P. J. (2013) Cancer chemistry : designing new drugs for cancer treatment. In: Pelengaris , Stella and Khan, Mike, (eds.) The molecular biology of cancer : a bridge from bench to bedside, 2nd Edition. Hoboken, NJ: Wiley-Blackwell. ISBN 9781118022870

Betanzos-Lara, Soledad, Habtemariam, Abraha and Sadler, P. J. (2013) Transfer hydrogenation reactions of photoactivatable N, N '-chelated ruthenium(II) arene complexes. Mexican Chemical Society Journal, Volume 57 (Number 3). pp. 160-168.

Romero-Canelón, Isolda, Salassa, Luca and Sadler, P. J. (2013) The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway. Journal of Medicinal Chemistry, Volume 56 (Number 3). pp. 1291-1300. doi:10.1021/jm3017442

2012

Garino, Claudio, Gallo, Erik, Smolentsev, Nikolay, Glatzel, Pieter, Gobetto, Roberto, Lamberti, Carlo, Sadler, P. J. and Salassa, Luca (2012) Resonant X-ray emission spectroscopy reveals d–d ligand-field states involved in the self-assembly of a square-planar platinum complex. Physical Chemistry Chemical Physics, Vol.14 (No.44). pp. 15278-15281. doi:10.1039/c2cp42451g

Zhao, Y., Roberts, Gareth M., Greenough, Simon E., Farrer, Nicola J., Peterson, Martin J. , Powell, William H., Stavros, Vasilios G. and Sadler, P. J. (2012) Two-photon-activated ligand exchange in platinum(II) complexes. Angewandte Chemie International Edition, Vol.51 (No.45). pp. 11263-11266. doi:10.1002/anie.201206283

Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9

Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111

Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h

Soldevila-Barreda, Joan J., Bruijnincx, Pieter C. A., Habtemariam, Abraha, Clarkson, Guy J., Deeth, Robert J. and Sadler, P. J. (2012) Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+. Organometallics, Vol.31 (No.16). pp. 5958-5967. doi:10.1021/om3006307

Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952

Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f

Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137

Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z

Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004

Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n

Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745

Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e

Ragazzon, Giulio, Bratsos, Ioannis, Alessio, E. (Enzo), Salassa, Luca, Habtemariam, Abraha, McQuitty, Ruth J., Clarkson, Guy J. and Sadler, P. J. (2012) Design of photoactivatable metallodrugs : selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes. Inorganica Chimica Acta, Vol.393 . pp. 230-238. doi:10.1016/j.ica.2012.06.031

Barry, Nicolas P. E. and Sadler, P. J. (2012) Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies. Chemical Society Reviews, Vol.41 (No.8). pp. 3264-3279. doi:10.1039/c2cs15300a

Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y

Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d

Betanzos-Lara, Soledad, Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Qamar, Bushra and Sadler, P. J. (2012) Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. Angewandte Chemie International Edition, Vol.51 (No.16). pp. 3897-3900. doi:10.1002/anie.201108175

Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y

Westendorf, A. F., Woods, J. A., Korpis, K., Farrer, Nicola J., Salassa, Luca, Robinson, K., Appleyard, V., Murray, K., Grunert, R., Thompson, A. M., Sadler, P. J. and Bednarski, P. J. (2012) Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)] : a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics, Vol.11 (No.9). pp. 1894-1904. doi:10.1158/1535-7163.MCT-11-0959

Butler, Jennifer S. (Jennifer Suzanne), Woods, Julie A., Farrer, Nicola J., Newton, Mark E. and Sadler, P. J. (2012) Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society, Vol.134 (No.40). pp. 16508-16511. doi:10.1021/ja3074159

Ross, Allison, Choi, Jong-Ha, Hunter, Tina M., Pannecouque, Christophe, Moggach, Stephen A., Parsons, Simon, De Clercq, Erik and Sadler, P. J. (2012) Zinc(ii) complexes of constrained antiviral macrocycles. Dalton Transactions, Volume 41 (Number 21). pp. 6408-6418. doi:10.1039/c2dt30140g

Tai, Hui-Chung, Zhao, Y., Farrer, Nicola J., Anastasi, Anna E., Clarkson, Guy J., Sadler, P. J. and Deeth, Robert J. (2012) A computational approach to tuning the photochemistry of platinum(IV) anticancer agents. Chemistry - A European Journal, Vol.18 (No.34). pp. 10630-10642. doi:10.1002/chem.201200782

Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d

2011

Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide — a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b

Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792

Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409

Fu, Ying, Shnyder, Steve D., Habtemariam, Abraha, Clarkson, Guy J., Cooper, Patricia A., Loadman, Paul M., Pizarro, Ana M. and Sadler, P. J. (2011) Organometallic osmium arene anticancer complexes. In: 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, 28 Aug - 1 Sep 2011. Published in: American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.242 17-BIOL. ISSN 0065-7727.

Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468

Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f

Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250

Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d

Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j

Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k

Scotcher, Jenna, Clarke, D. J., Weidt, Stefan K., Mackay, C. Logan, Hupp, Theodore, Sadler, P. J. and Langridge-Smith, Pat R. R. (2011) Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.22 (No.5). pp. 888-897. doi:10.1007/s13361-011-0088-x

Westendorf, Aron, Zerzankova, Lenka, Salassa, Luca, Sadler, P. J., Brabec, V. (Viktor) and Bednarski, Patrick J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, Vol.105 (No.5). pp. 652-662. doi:10.1016/j.jinorgbio.2011.01.003

Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932

Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Costantini, Giovanni, Scrivens, James H., Mukherjee, Arindam and Sadler, P. J. (2011) Human transferrin : association and fibril formation. American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.241 (No.171-BIOL ).

Ronconi, Luca and Sadler, P. J. (2011) Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions, Vol.40 (No.1). pp. 262-268. doi:10.1039/c0dt00546k

Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d

Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p

Farrer, Nicola J. and Sadler, P. J. (2011) Medicinal inorganic chemistry : state of the art, new trends, and a vision of the future. In: Alessio, E. (Enzo) , (ed.) Bioinorganic medicinal chemistry. Weinheim : Chichester: Wiley-VCH : John Wiley [distributor], pp. 1-48. ISBN 9783527326310

Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e

Barragán, Flavia, López-Senín, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, P. J. and Marchán, Vicente (2011) Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society, Vol.133 (No.35). pp. 14098-14108. doi:10.1021/ja205235m

Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide—a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b

Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e

Li, Huilin, Lin, Tzu-Yung, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Barrow, Mark P., Pizarro, Ana M., Qi, Yulin, Sadler, P. J. and O’Connor, Peter B. (2011) Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry, Vol.83 (No.24). pp. 9507-9515. doi:10.1021/ac202267g

2010

Salassa, Luca, Borfecchia, Elisa, Ruiu, Tiziana, Garino, Claudio, Gianolio, Diego, Gobetto, Roberto, Sadler, P. J., Cammarata, Marco, Wulff, Michael and Lamberti, Carlo (2010) Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry, Vol.49 (No.23). pp. 11240-11248. doi:10.1021/ic102021k

Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y

Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f

Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399

Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009

Williams, Jonathan P., Brown, Jeffery M., Campuzano, Iain and Sadler, P. J. (2010) Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chemical Communications, Vol.46 (No.30). pp. 5458-5460. doi:10.1039/c0cc00358a

Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a

Williams, Jonathan P., Phillips, Hazel I. A., Campuzano, Iain and Sadler, P. J. (2010) Shape changes induced by N-terminal platination of ubiquitin by cisplatin. Journal of The American Society for Mass Spectrometry, Vol.21 (No.7). pp. 1097-1106. doi:10.1016/j.jasms.2010.02.012

Novakova, Olga, Malina, J. (Jaroslav), Suchankova, Tereza, Kasparkova, Jana, Bugarcic, Tijana, Sadler, P. J. and Brabec, V. (Viktor) (2010) Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru-II complexes containing terphenyl arenes. Chemistry - A European Journal, Vol.16 (No.19). pp. 5744-5754. doi:10.1002/chem.200903078

Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496

Pizarro, Ana M., Melchart, Michael, Habtemariam, Abraha, Salassa, Luca, Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2010) Controlling the reactivity of ruthenium(II) arene complexes by tether ring-opening. Inorganic Chemistry, Vol.49 (No.7). pp. 3310-3319. doi:10.1021/ic902243q

Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990

Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614

Farrer, Nicola J., Woods, Julie A., Munk, Vivienne P., Mackay, Fiona S. and Sadler, P. J. (2010) Photocytotoxic trans-Diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology, Vol.23 (No.2). pp. 413-421. doi:10.1021/tx900372p

Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u

Bergamo, A., Masi, A., Peacock, Anna F. A., Habtemariam, Abraha, Sadler, P. J. and Sava, G. (2010) In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry, Vol.104 (No.1). pp. 79-86. doi:10.1016/j.jinorgbio.2009.10.005

Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2010) Activation mechanisms for organometallic anticancer complexes. In: Jaouen, Gérard and Metzler-Nolte, Nils, (eds.) Medicinal organometallic chemistry. Topics in Organometallic Chemistry, Vol.32 . Berlin ; New York: Springer-Verlag, pp. 21-56. ISBN 9783642131844

Habtemariam, Abraha, Betanzos-Lara, Soledad and Sadler, P. J. (2010) Di-μ-chloro(ethylbenzoate)diruthenium(II) : [(η6-etb)RuCl2]2. In: Inorganic Syntheses. Inorganic Syntheses, Vol.35 . Hoboken, NJ: John Wiley & Sons, Inc., pp. 160-163. ISBN 9780471682554

Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578

Farrer, Nicola J., Monk , Nicholas, Heron, Jonathan, Lough, Julie Ann and Sadler, P. J. (2010) (RSC)(2) : chemistry, performance, and pedagogy - an interactive approach to periodic trends. Chemistry Education Research and Practice, Vol.11 (No.4). pp. 308-313. doi:10.1039/c0rp90011g

2009

Rijt, Sabine H. van, Hebden, Andrew J., Amaresekera, Thakshila, Deeth, Robert J., Clarkson, Guy J., Parsons, S. (Simon), McGowan, Patrick C. and Sadler, P. J. (2009) Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes. Journal of Medicinal Chemistry, Vol.52 (No.23). pp. 7753-7764. doi:10.1021/jm900731j

Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003

Salassa, Luca, Phillips, Hazel I. A. and Sadler, P. J. (2009) Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N-3)(2)(OH)(2)(NH3)(2)] : insights from DFT calculations. Physical Chemistry Chemical Physics, Vol.11 (No.44). pp. 10311-10316. doi:10.1039/b912496a

Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g

Stewart, Alan J., Blindauer, Claudia A. and Sadler, P. J. (2009) Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein. Biochimie, Vol.91 (No.11-12). pp. 1518-1522. doi:10.1016/j.biochi.2009.08.002

Williams, Jonathan P., Lough, Julie Ann, Campuzano, Iain, Richardson, K. (Keith) and Sadler, P. J. (2009) Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Communications in Mass Spectrometry, Vol.23 (No.22). pp. 3563-3569. doi:10.1002/rcm.4285

Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366

Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017

Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z

Newstead, Simon, Fowler, Philip W., Bilton, Paul R., Carpenter, Elisabeth P., Sadler, P. J., Campopiano, Dominic J., Sansom, M. S. P. (Mark S. P.) and Iwata, So (2009) Insights into how nucleotide-binding domains power ABC transport. Structure, Vol.17 (NO.9). pp. 1213-1222. doi:10.1016/j.str.2009.07.009

Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g

Wang, Fuyi, Habtemariam, Abraha, van der Geer, Erwin P. L., Deeth, Robert J., Gould, Robert O., Parsons, Simon and Sadler, P. J. (2009) Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry, Vol.14 (No.7). pp. 1065-1076. doi:10.1007/s00775-009-0549-x

Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459

Hu, Wenbing, Luo, Qun, Ma, Xiaoyan, Wu, Kui, Liu, Jianan, Chen, Yi, Xiong, Shaoxiang, Wang, Jianping, Sadler, P. J. and Wang, Fuyi (2009) Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry - A European Journal, Vol.15 (No.27). pp. 6586-6594. doi:10.1002/chem.200900699

Williams, Jonathan P., Bugarcic, Tijana, Habtemariam, Abraha, Giles, K. (Kevin), Campuzano, Iain, Rodger, P. Mark and Sadler, P. J. (2009) Isomer separation and gas-phase configurations of organoruthenium anticancer complexes : ion mobility mass spectrometry and modeling. Journal of The American Society for Mass Spectrometry, Vol.20 (No.6). pp. 1119-1122. doi:10.1016/j.jasms.2009.02.016

Gray, Jennifer C., Pagelot, Alain, Collins, Anna, Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) and ruthenium(II) biphenyl sandwich complexes : x-ray crystal structures and Os-187 NMR spectroscopic studies in solution. European Journal of Inorganic Chemistry, Vol.2009 (No.18). pp. 2673-2677. doi:10.1002/ejic.200900244

Diakos, Connie I., Messerle, Barbara A., del Socorro Murdoch, P., Parkinson, J. A. (John A.), Sadler, P. J., Fenton, Ronald R. and Hambley, Trevor W. (2009) Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz=3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, Vol.48 (No.7). pp. 3047-3056. doi:10.1021/ic802207m

Sadler, P. J. (2009) Precious anticancer drugs. Chemistry & Industry (No.5). pp. 18-20.

Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. doi:10.1016/j.ica.2008.02.039

Salassa, Luca, Garino, Claudio, Salassa, Giovanni, Nervi, Carlo, Gobetto, Roberto, Lamberti, Carlo, Gianolio, Diego, Bizzarri, Ranieri and Sadler, P. J. (2009) Ligand-selective photodissociation from [Ru(bpy)(4AP)(4)](2+) : a spectroscopic and computational study. Inorganic Chemistry, Vol.48 (No.4). pp. 1469-1481. doi:10.1021/ic8015436

Rijt, Sabine H. van, Peacock, Anna F. A., Johnstone, Russell D. L., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry, Vol.48 (No.4). pp. 1753-1762. doi:10.1021/ic8020222

Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206

Sadler, P. J. (2009) Protein recognition of platinated DNA. ChemBioChem, Vol.10 (No.1). pp. 73-74. doi:10.1002/cbic.200800733

Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3

Sadler, P. J. (2009) Dalton Transactions themed issue on Metal Anticancer Compounds. Dalton Transactions (No.48). p. 10647. doi:10.1039/b923498p

Pizarro, Ana M. and Sadler, P. J. (2009) Metal ion–nucleic acid interactions in disease and medicine. In: Hud, Nicholas V. (Nicholas Vincent), (ed.) Nucleic Acid-Metal Ion Interactions. RSC biomolecular sciences . Cambridge, UK: Royal Society of Chemistry, pp. 350-416. ISBN 9780854041954

Rijt, Sabine H. van, Peacock, Anna F. A. and Sadler, P. J. (2009) Osmium arenes : a new class of potential anti-cancer agents. In: Bonetti, Andrea, MD and Leone, Roberto and Muggia, Franco M. and Howell, Stephen B., 1944-, (eds.) Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications. Cancer drug discovery and development . Totowa, N.J. : London: Humana : Springer [distributor], pp. 73-79. ISBN 978-1-60327-458-6

Farrer, Nicola J., Salassa, Luca and Sadler, P. J. (2009) Photoactivated chemotherapy (PACT) : the potential of excited-state d-block metals in medicine. Dalton Transactions, Vol.48 . pp. 10690-10701. doi:10.1039/b917753a

Salassa, Luca, Gianolio, Diego, Garino, Claudio, Salassa, Giovanni, Borfecchia, Elisa, Ruiu, Tiziana, Nervi, Carlo, Gobetto, Roberto, Bizzarri, Ranieri, Sadler, P. J. and Lamberti, Carlo (2009) Structure of [Ru(bpy)(n)(AP)((6-2n))](2+) homogeneous complexes: DFT calculation vs. EXAFS. In: 14th International Conference on X-Ray Absorption Fine Structure (XAFS14), Camerino, Italy, July 26-31, 2009. Published in: Journal of Physics: Conference Series, Vol.190 Article no. 012141. ISBN *****************. ISSN 1742-6596. doi:10.1088/1742-6596/190/1/012141

2008

Bugarcic, Tijana, Habtemariam, Abraha, Stepankova, Jana, Heringova, Pavla, Kasparkova, Jana, Deeth, Robert J., Johnstone, Russell D. L., Prescimone, Alessandro, Parkin, Andrew, Parsons, S. (Simon), Brabec, V. (Viktor) and Sadler, P. J. (2008) The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry, Vol.47 (No.24). pp. 11470-11486. doi:10.1021/ic801361m

Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317

Peacock, Anna F. A. and Sadler, P. J. (2008) Medicinal organometallic chemistry : designing metal arene complexes as anticancer agents. Chemistry - An Asian Journal, Vol.3 (No.11). pp. 1890-1899. doi:10.1002/asia.200800149

Ronconi, Luca and Sadler, P. J. (2008) Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews, Vol.252 (No.21-22). pp. 2239-2277. doi:10.1016/j.ccr.2008.01.016

Petzold, Holm and Sadler, P. J. (2008) Oxidation induced by the antioxidant glutathione (GSH). Chemical Communications (No.37). pp. 4413-4415. doi:10.1039/b805358h

Bugarcic, Tijana, Novakova, Olga, Halamikova, Anna, Zerzankova, Lenka, Vrana, Oldrich, Kasparkova, Jana, Habtemariam, Abraha, Parsons, S. (Simon), Sadler, P. J. and Brabec, V. (Viktor) (2008) Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry, Vol.51 (No.17). pp. 5310-5319. doi:10.1021/jm8003043

Gray, Jennifer C., Habtemariam, Abraha, Winnig, Marcel, Meyerhof, Wolfgang and Sadler, P. J. (2008) Sweetening ruthenium and osmium : organometallic arene complexes containing aspartame. Journal of Biological Inorganic Chemistry, Vol.13 (No.7). pp. 1111-1120. doi:10.1007/s00775-008-0396-1

Dougan, Sarah J., Habtemariam, Abraha, McHale, Sarah E., Parsons, S. (Simon) and Sadler, P. J. (2008) Catalytic organometallic anticancer complexes. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.33). pp. 11628-11633. doi:10.1073/pnas.0800076105

Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3

Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w

Euser, T. G., Chen, J. S. Y., Scharrer, M., Russell, Philip St. J., Farrer, Nicola J. and Sadler, P. J. (2008) Quantitative broadband chemical sensing in air-suspended solid-core fibers. Journal of Applied Physics, Vol.103 (No.10). p. 103108. doi:10.1063/1.2924408

Blindauer, Claudia A., Harrison, Mark D., Parkinson, J. A. (John A.), Robinson, N. J. (Nigel J.) and Sadler, P. J. (2008) Isostructural replacement of zinc by cadmium in bacterial metallothionein. In: 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, France, 19-22 May 2008. Published in: Metal Ions in Biology and Medicine, Vol.10 pp. 167-173. ISBN 978-2-7420-0714-1. ISSN 1257-2535.

Petzold, Holm, Xu, Jingjing and Sadler, P. J. (2008) Metal and ligand control of sulfenate reactivity : arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie International Edition, Vol.47 (No.16). pp. 3008-3011. doi:10.1002/anie.200705342

Wang, Fuyi, Weidt, Stefan, Xu, Jingjing, Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 18O-labeling. Journal of The American Society for Mass Spectrometry, Vol.19 (No.4). pp. 544-549. doi:10.1016/j.jasms.2007.12.002

Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013

Ghosh, Surajit, Mukherjee, Arindam, Sadler, P. J. and Verma, Sandeep (2008) Periodic iron nanomineralization in human serum transferrin fibrils. Angewandte Chemie International Edition, Vol.47 (No.12). pp. 2217-2221. doi:10.1002/anie.200705723

Ronconi, Luca and Sadler, P. J. (2008) Unprecedented carbon–carbon bond formation induced by photoactivation of a platinum(iv)-diazido complex. Chemical Communications (2). pp. 235-237. doi:10.1039/b714216a

Farrer, Nicola J. and Sadler, P. J. (2008) Photochemotherapy : targeted activation of metal anticancer complexes. Australian Journal of Chemistry, Vol.61 (No.9). pp. 669-674. doi:10.1071/CH08088

2007

Mackay, Fiona S., Woods, Julie A., Heringova, Pavia, Kasparkova, Jana, Pizarro, Ana M., Moggach, Stephen A., Parsons, Simon, Brabec, V. (Viktor) and Sadler, P. J. (2007) A potent cytotoxic photoactivated platinum complex. Proceedings of the National Academy of Sciences of the United States of America, Vol.104 (No.52). pp. 20743-20748. doi:10.1073/pnas.0707742105

Melchart, Michael, Habtemariam, Abraha, Novakova, Olga, Moggach, Stephen A., Fabbiani, Francesca P. A., Parsons, Simon, Brabec, V. (Viktor) and Sadler, P. J. (2007) Bifunctional amine-tethered Ruthenium(II) arene complexes form monofunctional adducts on DNA. Inorganic Chemistry, Vol.46 (No.21). pp. 8950-8962. doi:10.1021/ic700799w

Dougan, Sarah J., Mukherjee, Arindam, Habtemariam, Abraha and Sadler, P. J. (2007) INOR 147-Kinetically-inert organometallic ruthenium arene complexes: A new class of cancer cell cytotoxic agents. In: UNSPECIFIED. Published in: Abstracts of papers of the American Chemical Society, Vol.234 ISSN 0065-7727.

Blindauer, Claudia A., Razi, M. Tahir, Campopiano, Dominic J. and Sadler, P. J. (2007) Histidine ligands in bacterial metallothionein enhance cluster stability. Journal of Biological Inorganic Chemistry, Vol.12 (No.3). pp. 393-405. doi:10.1007/s00775-006-0196-4

Peacock, Anna F. A., Melchart, Michael, Deeth, Robert J., Habtemariam, Abraha, Parsons, Simon and Sadler, P. J. (2007) Osmium(II) and ruthenium(II) arene maltolato complexes : rapid hydrolysis and nucleobase binding. Chemistry : A European Journal, Volume 13 (Number 9). pp. 2601-2613. doi:10.1002/chem.200601152

Dougan, Sarah J. and Sadler, P. J. (2007) The design of organometallic ruthenium arene anticancer agents. Chimia, Volume 61 (Number 11). pp. 704-715. doi:10.2533/chimia.2007.704

2006

Habtemariam, Abraha, Melchart, Michael, Fernández, Rafael, Parsons, Simon, Oswald, Iain D. H., Parkin, Andrew, Fabbiani, Francesca P. A., Davidson, James E., Dawson, Alice, Aird, Rhona E., Jodrell, Duncan I. and Sadler, P. J. (2006) Structure−activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry, Volume 49 (Number 23). pp. 6858-6868. doi:10.1021/jm060596m

2005

Wang, Fuyi, Xu, Jingjing, Habtemariam, Abraha, Bella, Juraj and Sadler, P. J. (2005) Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex : detection of a sulfenato intermediate. Journal of the American Chemical Society, Volume 127 (Number 50). pp. 17734-17743. doi:10.1021/ja053387k

2002

Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723