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Rashid, Goran M. M., Rivière, Guillaume, Cottyn-Boitte, Betty, Majira, Amel, Cézard, Laurent, Sodré, Victoria, Lam, Richard, Fairbairn, Julia A., Baumberger, Stéphanie and Bugg, Timothy D. H. (2024) Ether bond cleavage of a phenylcoumaran beta-5 lignin model compound and polymeric lignin catalysed by a LigE-type etherase from Agrobacterium sp. ChemBioChem . e202400132. doi:10.1002/cbic.202400132 ISSN 1439-4227. (In Press)
ChacΟn, Micaela, Percival, Ellen, Bugg, Timothy D. H. and Dixon, Neil (2024) Engineered co-culture for consolidated production of phenylpropanoids directly from aromatic-rich biomass. Bioresource Technology, 391 (Part A). 129935. doi:10.1016/j.biortech.2023.129935 ISSN 0960-8524.
Bugg, Tim (2024) The chemical logic of enzymatic lignin degradation. Chemical Communications . doi:10.1039/D3CC05298B ISSN 1359-7345. (In Press)
Rashid, Goran M. M., SodrΓ©, Victoria, Luo, Jia and Bugg, Timothy D. H. (2023) Overexpression of endogenous multiβcopper oxidases mcoA and mcoC in Rhodococcus jostii RHA1 enhances lignin bioconversion to 2,4βpyridineβdicarboxylic acid. Biotechnology and Bioengineering . doi:10.1002/bit.28620 ISSN 0006-3592. (In Press)
Yasin, Rabia, Rashid, Goran M. M., Ali, Imran and Bugg, Timothy D. H. (2023) Engineering of Rhodococcus jostii RHA1 for utilisation of carboxymethylcellulose. Heliyon, 9 (9). E19511. doi:10.1016/j.heliyon.2023.e19511 ISSN 2405-8440.
Tramontina, Robson, Ciancaglini, Iara, Roman, Ellen K. B., ChacΓ³n, Micaela G., CorrΓͺa, Thamy L. R., Dixon, Neil, Bugg, Timothy D. H. and Squina, Fabio Marcio (2023) Sustainable biosynthetic pathways to value-added bioproducts from hydroxycinnamic acids. Applied Microbiology and Biotechnology, 107 . pp. 4165-4185. doi:10.1007/s00253-023-12571-8 ISSN 0175-7598.
Quareshy, Mussa, Shanmugam, Muralidharan, Cameron, Alexander, Bugg, Tim and Chen, Yin (2023) Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site. The FEBS Journal, 290 (11). pp. 2939-2953. doi:10.1111/febs.16722 ISSN 1742-464X.
Nurika, Irnia, Aristya, Yuvira Ivana, Azizah, Nurul, Sunyoto, Nimas Mayang Sabrina, Suhartini, Sri, Bugg, Timothy D. H. and Barker, Guy C. (2023) Enhancement of the ligninolytic activity of Lysinibacillus sphaericus by the addition of MnSO4 and its impact on subsequent methane production from Oil Palm Empty Fruit Bunches (OPEFB). Bioresource Technology Reports, 22 . 101394. doi:10.1016/j.biteb.2023.101394 ISSN 2589-014X.
Alruwaili, Awatif, Rashid, Goran M. M. and Bugg, Tim (2023) Application of Rhodococcus jostii RHA1 glycolate oxidase as an efficient accessory enzyme for lignin conversion by bacterial Dyp peroxidase enzymes. Green Chemistry, 25 (9). pp. 3549-3560. doi:10.1039/D3GC00475A ISSN 1463-9262.
Alruwaili, Awatif, Rashid, Goran M. M., SodrΓ©, Victoria, Mason, James, Rehman, Zainab, Menakath, Anjali K., Cheung, David L., Brown, Steven P. and Bugg, Timothy D. H. (2023) Elucidation of microbial lignin degradation pathways using synthetic isotope-labelled lignin. RSC Chemical Biology, 4 (1). pp. 47-55. doi:10.1039/d2cb00173j ISSN 2633-0679.
Ehibhatiomhan, Austine O., Rahmanpour, Rahman, Farnaud, Sebastien, Bugg, Timothy D. H. and Mendel-Williams, Sharon (2023) Periplasmic expression of Pseudomonas fluorescens peroxidase Dyp1B and site-directed mutant Dyp1B enzymes enhances polymeric lignin degradation activity in Pseudomonas putida KT2440. Enzyme & Microbial Technology, 162 . 110147. doi:10.1016/j.enzmictec.2022.110147 ISSN 0141-0229.
Karagoz, P., Khiawjan, S., Marques, M. P. C., Santzouk, S., Bugg, Tim and Lye, G. (2023) Pharmaceutical applications of lignin-derived chemicals and lignin-based materials : linking lignin source and processing with clinical indication. Biomass Conversion and Biorefinery . doi:10.1007/s13399-023-03745-5 ISSN 2190-6815. (In Press)
JimΓ©nez, Diego Javier, ΓztΓΌrk, BaΕak, Wei, Ren, Bugg, Timothy D. H., Amaya Gomez, Carol Viviana, Salcedo Galan, Felipe, Castro-Mayorga, Jinneth Lorena, Saldarriaga, Juan Fernando, Tarazona, Natalia Andrea and Zhou, Ning-Yi (2022) Merging plastics, microbes, and enzymes : highlights from an international workshop. Applied and Environmental Microbiology . doi:10.1128/aem.00721-22 ISSN 0099-2240.
Nurika, Irnia, Shabrina, Eka Nur, Azizah, Nurul, Suhartini, Sri, Bugg, Timothy D. H. and Barker, Guy C. (2022) Application of ligninolytic bacteria to the enhancement of lignocellulose breakdown and methane production from oil palm empty fruit bunches (OPEFB). Bioresource Technology Reports, 17 . 100951. doi:10.1016/j.biteb.2022.100951 ISSN 2589-014X.
GΓ³mez-Γlvarez, Helena, Iturbe, Pablo, Rivero-Buceta, Virginia, Mines, Paul, Bugg, Tim, Nogales, Juan and DΓaz, Eduardo (2022) Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresource Technology, 346 . 126638. doi:10.1016/j.biortech.2021.126638 ISSN 0960-8524.
Kerr, Rachel, Fairbairn, Julia A., Merritt, Andrew T. and Bugg, Timothy D. H. (2021) Peptidomimetic analogues of an Arg-Trp-x-x-Trp motif responsible for interaction of translocase MraY with bacteriophage phiX174 lysis protein E. Bioorganic & Medicinal Chemistry, 52 . 116502. doi:10.1016/j.bmc.2021.116502 ISSN 0968-0896.
Bugg, Tim, Williamson, James J. and Alberti, Fabrizio (2021) Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals. Renewable and Sustainable Energy Reviews , 152 . 111674. doi:10.1016/j.rser.2021.111674 ISSN 1364-0321.
Rouches, E., GΓ³mez-Alvarez, H., Majira, A., MartΓn-Moldes, Z., Nogales, J., DΓaz, E., Bugg, Tim and Baumberger, S. (2021) Assessment strategy for bacterial lignin depolymerization : Kraft lignin and synthetic lignin bioconversion with Pseudomonas putida. Bioresource Technology Reports, 15 . 100742. doi:10.1016/j.biteb.2021.100742 ISSN 2589-014X.
Rashid, Goran M. M. and Bugg, Tim (2021) Enhanced biocatalytic degradation of lignin using combinations of lignin-degrading enzymes and accessory enzymes. Catalysis Science & Technology, 11 (3). pp. 3568-3577. doi:10.1039/D1CY00431J ISSN 2044-4753.
Shanmugam, Muralidharan, Quareshy, Mussa, Cameron, Alexander, Bugg, Timothy D. H. and Chen, Yin (2021) Lightβactivated electron transfer and catalytic mechanism of carnitine oxidation by Rieskeβtype oxygenase from human microbiota. Angewandte Chemie International Edition, 60 (9). pp. 4529-4534. doi:10.1002/anie.202012381 ISSN 1433-7851.
Spence, Edward M., Calvo-Bado, Leonides, Mines, Paul and Bugg, Timothy D. H. (2021) Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin. Microbial Cell Factories, 20 (1). 15. doi:10.1186/s12934-020-01504-z ISSN 1475-2859.
Quareshy, Mussa, Shanmugam, Muralidharan, Townsend, Eleanor, Jameson, Eleanor, Bugg, Timothy D. H., Cameron, Alexander and Chen, Yin (2021) Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer. Journal of Biological Chemistry, 296 . 100038. doi:10.1074/jbc.RA120.016019 ISSN 0021-9258.
DΓaz-GarcΓa, Laura, Bugg, Timothy D. H. and JimΓ©nez, Diego Javier (2020) Exploring the lignin catabolism potential of soil-derived lignocellulolytic microbial consortia by a gene-centric metagenomic approach. Microbial Ecology, 80 . 885-896 . doi:10.1007/s00248-020-01546-1 ISSN 0095-3628.
Spence, Edward M., Scott, Heather T., Dumond, Louison, Calvo-Bado, Leo A., Monaco, Sabrina di, Williamson, James J., Persinoti, Gabriela F., Squina, Fabio M. and Bugg, Timothy D. H. (2020) The hydroxyquinol degradation pathway in Rhodococcus jostii RHA1 and Agrobacterium species is an alternative pathway for degradation of protocatechuic acid and lignin fragments. Applied and Environmental Microbiology, 86 (19). e01561--20. doi:10.1128/AEM.01561-20 ISSN 0099-2240.
Patel, Bhautikkumar, Kerr, Rachel, Malde, Alpeshkumar K., Zunk, Matthew, Bugg, Timothy D. H., Grant, Gary and Rudrawar, Santosh (2020) Simplified novel muraymycin analogues ; using a serine template strategy for linking key pharmacophores. ChemMedChem, 15 (15). pp. 1429-1438. doi:10.1002/cmdc.202000033 ISSN 1860-7179.
Williamson, James J., Bahrin, Nurfariza, Hardiman, Elizabeth M. and Bugg, Timothy D. H. (2020) Production of substituted styrene bioproducts from lignin and lignocellulose using engineered pseudomonas putida KT2440. Biotechnology Journal, 15 (7). e1900571. doi:10.1002/biot.201900571 ISSN 1860-6768.
Wilkinson, Rachael C., Rahmanpour, Rahman, Jamshidi, Shirin, FΓΌlΓΆp, Vilmos and Bugg, Timothy D. H. (2020) Extracellular alpha/beta-hydrolase from Paenibacillus species shares structural and functional homology to tobacco salicylic acid binding protein 2. Journal of Structural Biology, 210 (3). 107496. doi:10.1016/j.jsb.2020.107496 ISSN 1047-8477.
Bugg, Timothy D. H., Williamson, James J. and Rashid, Goran M. M. (2020) Bacterial enzymes for lignin depolymerisation : new biocatalysts for generation of renewable chemicals from biomass. Current Opinion in Chemical Biology, 55 . pp. 26-33. doi:10.1016/j.cbpa.2019.11.007 ISSN 1367-5931.
Granja-Travez, Rommel Santiago, Persinoti, Gabriela Felix, Squina, Fabio M. and Bugg, Timothy D. H. (2020) Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism. Applied Microbiology and Biotechnology, 104 . pp. 3305-3320. doi:10.1007/s00253-019-10318-y ISSN 0175-7598.
Nurika, Irnia, Eastwood, Daniel C., Bugg, Timothy D. H. and Barker, Guy C. (2020) Biochemical characterization of Serpula lacrymans iron-reductase enzymes in lignocellulose breakdown. Journal of Industrial Microbiology & Biotechnology, 47 (1). pp. 145-154. doi:10.1007/s10295-019-02238-7 ISSN 1367-5435.
Tramontina, Robson, Galman, James L., Parmeggiani, Fabio, Derrington, Sasha R., Bugg, Timothy D. H., Turner, Nicholas J., Squina, Fabio M. and Dixon, Neil (2020) Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass. Green Chemistry, 22 (1). pp. 144-152. doi:10.1039/c9gc02359c ISSN 1463-9270.
Wei, Zhen, Wilkinson, Rachael C., Rashid, Goran M. M., Brown, David, FΓΌlΓΆp, Vilmos and Bugg, Tim (2019) Characterisation of thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5 involved in degradation of aryl-C2 lignin degradation fragments. Biochemistry, 58 (52). pp. 5281-5293. doi:10.1021/acs.biochem.9b00177 ISSN 0006-2960.
Bugg, Tim and Kerr, Rachel V. (2019) Mechanism of action of nucleoside antibacterial natural product antibiotics. Journal of Antibiotics, 72 . pp. 865-876. doi:10.1038/s41429-019-0227-3 ISSN 0021-8820.
Rahmanpour, Rahman, Ehibhatiomhan, Austine, Huang, Yuling, Ashley, Ben, Rashid, Goran M. M., Mendel-Williams, Sharon and Bugg, Timothy D. H. (2019) Protein engineering of pseudomonas fluorescens peroxidase Dyp1B for oxidation of phenolic and polymeric lignin substrates. Enzyme and Microbial Technology, 123 . pp. 21-29. doi:10.1016/j.enzmictec.2019.01.002 ISSN 0141-0229.
Granja-Travez, Rommel Santiago and Bugg, Timothy D. H. (2018) Characterization of multicopper oxidase CopA from Pseudomonas putida KT2440 and Pseudomonas fluorescens Pf-5 : Involvement in bacterial lignin oxidation. Archives of Biochemistry and Biophysics, 660 . pp. 97-107. doi:10.1016/j.abb.2018.10.012 ISSN 0003-9861.
Rashid, Goran M. M., Zhang, Xiaoyang, Wilkinson, Rachael C., FΓΌlΓΆp, Vilmos, Cottyn, Betty, Baumberger, StΓ©phanie and Bugg, Tim (2018) Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical. ACS Chemical Biology . doi:10.1021/acschembio.8b00557 ISSN 1554-8929.
Persinoti, Gabriela F., PaixΓ£o, Douglas A. A., Bugg, Timothy D. H. and Squina, Fabio M. (2018) Genome Sequence of Lysinibacillus sphaericus, a Lignin-Degrading Bacterium Isolated from Municipal Solid Waste Soil. Genome Announcements, 6 (18). e00353-18. doi:10.1128/genomeA.00353-18 ISSN 2169-8287.
Granja-Travez, R. S., Wilkinson, Rachael C., Persinoti, G. F., Squina, F. M., FΓΌlΓΆp, Vilmos and Bugg, Tim (2018) Structural and functional characterisation of multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate. FEBS Journal, 285 (9). pp. 1684-1700. doi:10.1111/febs.14437 ISSN 1742-4658.
Moraes, Eduardo C., Alvarez, Thabata M., Persinoti, Gabriela F., Tomazetto, Geizecler, Brenelli, Livia B., PaixΓ£o, Douglas A. A., Ematsu, Gabriela C., Aricetti, Juliana A., Caldana, Camila, Dixon, Neil, Bugg, Tim and Squina, Fabio M. (2018) Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization. Biotechnology for Biofuels, 11 (75). doi:10.1186/s13068-018-1073-4 ISSN 1754-6834.
Eyice, Γzge, Myronova, Natalia, Pol, Arjan, Carrion, Ornella, Todd, Jonathan, Smith, Tom J., Gurman, Stephen J., Cuthbertson, Adam, Mazard, Sophie, Mennink-Kersten, Monique A. S. H. , Bugg, Tim, Andersson, K. Kristoffer, Johnston, Andrew W. B., Op Den Camp, Huub J. M. and SchΓ€fer, Hendrik (2018) Bacterial SBP56 identified as a Cu-dependent methanethiol oxidase widely distributed in the biosphere. ISME Journal, 12 (1). 145-160 . doi:10.1038/ismej.2017.148 ISSN 1751-7362.
Konstantopoulou, Marina, Slator, Paddy J., Taylor, Charles R., Wellington, E. M. H., Allison, Gordon, Harper, Andrea L., Bancroft, Ian and Bugg, Timothy D. H. (2017) Variation in susceptibility to microbial lignin oxidation in a set of wheat straw cultivars : influence of genetic, seasonal and environmental factors. Nordic Pulp and Paper Research Journal, 32 (4). pp. 493-507. ISSN 0283-2631.
Millar, Robert, Rahmanpour, Rahman, Wei Jia Yuan, Eugenie, White, Catharine and Bugg, Tim (2017) Esterase EstK from Pseudomonas putida mt-2 : an enantioselective acetylesterase with activity for deacetylation of xylan and poly(vinylacetate). Biotechnology and Applied Biochemistry, 64 (6). pp. 803-809. ISSN 0885-4513.
Rashid, Goran M. M., Duran-Pena, Maria Jesus, Rahmanpour, Rahman , Sapsford, Devin and Bugg, Tim (2017) Delignification and enhanced gas release from soil containing Lignocellulose by treatment with bacterial lignin degraders. Journal of Applied Microbiology, 123 (1). pp. 159-171. doi:10.1111/jam.13470 ISSN 1364-5072.
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 . 14414 . doi:10.1038/ncomms14414 ISSN 2041-1723.
Rahmanpour, Rahman, King, Lloyd D. W and Bugg, Tim (2017) Identification of an extracellular bacterial flavoenzyme that can prevent re-polymerisation of lignin fragments. Biochemical and Biophysical Research Communications, 482 (1). pp. 57-61. doi:10.1016/j.bbrc.2016.10.144 ISSN 0006-291X.
Awan, Sajjad Zahoor, Chandler, Jake Owen, Harrison, Peter J., Sergeant, Martin J., Bugg, Tim and Thompson, Andrew David (2017) Promotion of germination using hydroxamic acid inhibitors of 9-cis-epoxycarotenoid dioxygenase. Frontiers in Plant Science, 8 . 357. doi:10.3389/fpls.2017.00357 ISSN 1664-462X.
Zhu, Yijun , Ksibe, Amira Z., SchΓ€fer, Hendrik, Blindauer, Claudia A., Bugg, Tim and Chen, Yin (2016) O2-independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris. FEBS Journal, 283 (21). pp. 3979-3993. doi:10.1111/febs.13902 ISSN 1742-464X.
Lancefield, Christopher S., Rashid, Goran M. M., Bouxin, Florent, Wasak, Agata, Tu, Wei-Chien, Hallett, Jason P., Zein, Sharif, Rodriguez, Jaime, Jackson, S. David, Westwood, Nicholas J. and Bugg, Timothy D. H. (2016) An investigation of the chemocatalytic and biocatalytic valorisation of a range of different lignin preparations : the importance of Ξ²-O-4 content. ACS Sustainable Chemistry & Engineering . doi:10.1021/acssuschemeng.6b01855 ISSN 2168-0485.
Rahmanpour, Rahman , Rea, Dean, Jamshidi, Shirin, FΓΌlΓΆp, Vilmos and Bugg, Tim (2016) Structure of thermobifida fusca DyP-type peroxidase and activity towards kraft lignin and lignin model compounds. Archives of Biochemistry and Biophysics, 594 . pp. 54-60. doi:10.1016/j.abb.2016.02.019 ISSN 0003-9861.
Bugg, Tim, Rodolis, Maria T., Mihalyi, Agnes and Jamshidi, Shirin (2016) Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage <phi>X174 lysis protein E, and cationic antibacterial peptides. Bioorganic and Medicinal Chemistry . doi:10.1016/j.bmc.2016.03.018 ISSN 0968-0896.
Mycroft, Zoe, Gomis, Maria, Mine, Paul, Law, Paul and Bugg, Tim (2015) Biocatalytic conversion of lignin to aromatic dicarboxylic acids in Rhodococcus jostii RHA1 by re-routing aromatic degradation pathways. Green chemistry, 17 (11). pp. 4974-4979. doi:10.1039/c5gc01347j ISSN 1463-9262.
Harrison, Peter J., Newgas, Sophie A., Descombes, Flora, Shepherd, Sarah A., Thompson, Andrew J. and Bugg, Tim (2015) Biochemical characterization and selective inhibition of Ξ²-carotenecis-transisomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway. FEBS Journal . doi:10.1111/febs.13400 ISSN 1742-464X.
Rashid, Goran M. M., Taylor, Charles R. (Charles Robert), Liu, Yangqingxu, Zhang, Xiaoyang, Rea, Dean, FΓΌlΓΆp, Vilmos and Bugg, Tim (2015) Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation. ACS chemical biology, 10 (10). pp. 2286-2294. doi:10.1021/acschembio.5b00298 ISSN 1554-8929.
Rodolis, Maria T., Mihalyi, Agnes, Ducho, Christian, Eitel, Kornelia, Gust, Bertolt, Goss, Rebecca J. M. and Bugg, Tim (2014) Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a proteinβprotein interaction site in translocase MraY. Chemical Communications, 50 (86). pp. 13023-13025. doi:10.1039/c4cc06516f ISSN 1359-7345.
Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. (Michael J.) and Bugg, Tim (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. doi:10.1099/mic.0.079442-0 ISSN 1350-0872.
Rodolis, Maria T., Mihalyi, Agnes, O'Reilly, Amy M., Slikas, Justinas, Roper, David I., Hancock, Robert E. W. and Bugg, Tim (2014) Identification of a novel inhibition site in Translocase MraY based upon the site of interaction with Lysis Protein E from Bacteriophage ΟX174. Chembiochem, Volume 15 (Number 9). pp. 1300-1308. doi:10.1002/cbic.201402064 ISSN 1439-4227.
Van Norman, Jaimie M., Zhang, Jingyuan, Cazzonelli, Christopher I., Pogson, Barry J., Harrison, Peter J. , Bugg, Tim, Chan, Kai Xun, Thompson, Andrew J. and Benfey, Philip N. (2014) Periodic root branching inArabidopsis requires synthesis of an uncharacterized carotenoid derivative. Proceedings of the National Academy of Sciences of the United States of America, Volume 111 (Number 13). E1300-E1309. doi:10.1073/pnas.1403016111 ISSN 0027-8424.
Zhu, Yijun , Jameson, Eleanor, Cosatti, Marialuisa , SchΓ€fer, Hendrik, Rajakumar, Kumar , Bugg, Tim and Chen, Yin (2014) Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proceedings of the National Academy of Sciences of the United States of America, 111 (11). pp. 4268-4273. doi:10.1073/pnas.1316569111 ISSN 0027-8424.
Bugg, Tim (2014) How to break the rules of dioxygen activation. Chemistry & Biology, Volume 21 (Number 2). pp. 168-169. doi:10.1016/j.chembiol.2014.01.007 ISSN 1074-5521.
Harrison, Peter J. and Bugg, Tim (2014) Enzymology of the carotenoid cleavage dioxygenases : Reaction mechanisms, inhibition and biochemical roles. Archives of Biochemistry and Biophysics, Volume 544 . pp. 105-111. doi:10.1016/j.abb.2013.10.005 ISSN 0003-9861.
Williams, Allison H., Boneca, Ivo G., Burrows, Lori L. and Bugg, Tim (2014) The dynamics of peptidoglycan structure and function : conference report on the 3rd Great Wall Symposium. Research in Microbiology, Volume 165 (Number 1). pp. 60-67. doi:10.1016/j.resmic.2013.11.002 ISSN 0923-2508.
Brown, Kieron, Vial, Sarah C. M., Dedi, Neesha, Westcott, James, Scally, Stephen, Bugg, Tim, Charlton, Peter A. and Cheetham, Graham M. T. (2013) Crystal structure of the Pseudomonas aeruginosa MurG : UDP-GlcNAc substrate complex. Protein and Peptide Letters, Volume 20 (Number 9). pp. 1002-1008. doi:10.2174/0929866511320090006 ISSN 0929-8665.
Rahmanpour, Rahman and Bugg, Tim (2013) Assembly in vitro of rhodococcus jostii RHA1 encapsulin and peroxidase DypB to form a nano-compartment. FEBS Journal, Volume 280 (Issue 9). pp. 2097-2104. doi:10.1111/febs.12234 ISSN 1742-464x.
Sandhu, Sandeep, Schouten, James A., Thompson, Julie, Davis, Mark and Bugg, Tim (2012) Detection of Staphylococcus aureus cell walls by enzyme-linked immunoassay using antibodies prepared from a semi-synthetic peptidoglycan precursor. The Analyst, Vol.137 (No.5). pp. 1130-1136. doi:10.1039/c2an16036f ISSN 0003-2654.
Bugg, Tim (2012) Biosynthesis : imaging cell-wall biosynthesis live. Nature Chemistry, Vol.5 (No.1). pp. 10-12. doi:10.1038/nchem.1538 ISSN 1755-4330.
Taylor, C. R. (Charles R.), Hardiman, E. M., Ahmad, Mussawar, Sainsbury, P. D., Norris, Paul R. and Bugg, Tim (2012) Isolation of bacterial strains able to metabolize lignin from screening of environmental samples. Journal of Applied Microbiology, Volume 113 (Number 3). pp. 521-530. doi:10.1111/j.1365-2672.2012.05352.x ISSN 1364-5072.
Coles, Stuart R., Ahmad, Mark, Barker, Guy C., Bugg, Tim, Clark, Andrew J., Collis, Alana and Kirwan, Kerry (2012) Wealth out of waste. In: 19th Annual Meeting of the BioEnvironmental Polymer Society - BEPS, Vienna, Austria, 28-30 Sep 2012 (Unpublished)
Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006 ISSN 0167-7799.
Roberts, Joseph N., Singh, Rahul, Grigg, Jason C., Murphy, Michael E. P., Bugg, Tim and Eltis, Lindsay D. (2011) Characterization of dye-decolorizing peroxidases from Rhodococcus jostii RHA1. Biochemistry, Vol.50 (No.23). pp. 5108-5119. doi:10.1021/bi200427h ISSN 0006-2960.
Ahmad, Mark, Roberts, Joseph N., Hardiman, Elizabeth M, Singh, Rahul, Eltis, Lindsay D. and Bugg, Tim (2011) Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase. Biochemistry, Vol.50 (No.23). pp. 5096-5107. doi:10.1021/bi101892z ISSN 0006-2960.
Hattersley, John G., PΓ©rez-VelΓ‘zquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009 ISSN 01692607.
Bugg, Tim, Ahmad, Mark, Hardiman, Elizabeth M. and Rahmanpour, Rahman (2011) Pathways for degradation of lignin in bacteria and fungi. Natural Product Reports, Vol.28 (No.12). pp. 1883-1896. doi:10.1039/c1np00042j ISSN 0265-0568.
Bugg, Tim, Ahmad, Mark, Hardiman, Elizabeth M. and Singh, Rahul (2011) The emerging role for bacteria in lignin degradation and bio-product formation. Current Opinion in Biotechnology, Vol.22 (No.3). pp. 394-400. doi:10.1016/j.copbio.2010.10.009 ISSN 0958-1669.
LΓ³pez-RΓ‘ez, Juan A., Kohlen, Wouter, Charnikhova, Tatsiana, Mulder, Patrick, Undas, Anna K., Sergeant, Martin J., Verstappen, Francel, Bugg, Tim, Thompson, Andrew J., Ruyter-Spira, Carolien and Bouwmeester, Harro (2010) Does abscisic acid affect strigolactone biosynthesis? New Phytologist, Vol.87 (No.2). pp. 343-354. doi:10.1111/j.1469-8137.2010.03291.x ISSN 0028-646X.
Ahmad, Mark, Taylor, C. R. (Charles R.), Pink, David, Burton, Kerry S., Eastwood, Daniel C., Bending, G. D. and Bugg, Tim (2010) Development of novel assays for lignin degradation : comparative analysis of bacterial and fungal lignin degraders. Molecular BioSystems, Vol.6 (No.5). pp. 815-821. doi:10.1039/b908966g ISSN 1742-206X.
Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S. and Bugg, Tim (2010) Inhibition of escherichia coli glycosyltransferase MurG and mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics. Bioorganic & Medicinal Chemistry, Vol.18 (No.7). pp. 2651-2663. doi:10.1016/j.bmc.2010.02.026 ISSN 0968-0896.
Xin, Meite and Bugg, Tim (2010) Biomimetic formation of 2-tropolones by dioxygenase-catalysed ring expansion of substituted 2,4-cyclohexadienones. ChemBioChem, Vol.11 (No.2). pp. 272-276. doi:10.1002/cbic.200900631 ISSN 1439-4227.
Winn, M. (Michael), Goss, Rebecca J. M., Kimura, Ken-ichi and Bugg, Tim (2010) Antimicrobial nucleoside antibiotics targeting cell wall assembly : recent advances in structure-function studies and nucleoside biosynthesis. Natural Product Reports, Vol.27 (No.2). pp. 279-304. ISSN 0265-0568 doi:10.1039/b816215h
Ahmad, Mark, Bugg, Tim, Clark, Andrew J., Coles, Stuart R., Collis, Alana, Kirwan, Kerry, Koncsag, Claudia I., Barker, Guy C., Burton, Kerry S., Eastwood, Daniel C. and Pink, David (2010) Wealth out of waste. In: 3rd International IUPAC Conference on Green Chemistry, Ottawa, Ontario, Canada, Aug 15-18, 2010
Bugg, Tim (2009) Oxygenases get to grips with polypeptides. Structure, Vol.17 (No.7). pp. 913-914. ISSN 0969-2126 doi:10.1016/j.str.2009.06.004
Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395 ISSN 0264-6021.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028 ISSN 0968-0896.
Sergeant, Martin J., Li, J.J., Fox, C., Brookbank, N., Rea, Dean, Bugg, Tim and Thompson, Andrew J. (2009) Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching. Journal of Biological Chemistry, Vol.284 (No.8). pp. 5257-5264. doi:10.1074/jbc.M805453200 ISSN 0021-9258.
Vinatier, Virginie, Blakey, Carl B., Braddick, Darren, Johnson, Benjamin R. G., Evans, Stephen D. and Bugg, Tim (2009) In vitro biosynthesis of bacterial peptidoglycan using D-Cys-containing precursors : fluorescent detection of transglycosylation and transpeptidation. Chemical Communications (No.27). pp. 4037-4039. doi:10.1039/b819869a ISSN 1359-7345.
Brivio, Michela, Schlosrich, Janne, Ahmad, Mark, Tolond, Caroline and Bugg, Tim (2009) Investigation of acid-base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry. Organic & Biomolecular Chemistry, Vol.7 (No.7). pp. 1368-1373. doi:10.1039/b821559f ISSN 1477-0520.
Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim and Levesque, Roger C. (2008) Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC Biochemistry, Vol.9 (No.33). doi:10.1186/1471-2091-9-33 ISSN 1471-2091.
De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200 ISSN 0021-9258.
Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., FΓΌlΓΆp, Vilmos, Bugg, Tim and Roper, David I. (2008) Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry, Vol.47 (No.38). pp. 9955-9965. doi:10.1021/bi800943g ISSN 0006-2960.
Dodd, Charlotte E., Johnson, Benjamin R. G., Vinatier, Virginie, Bugg, Tim, Bushby, Richard J., Jeuken, Lars J. C. and Evans, Stephen D. (2008) COLL 53-Peptidoglycan biosynthesis on lipid bilayers. In: 236th National Meeting of the American-Chemical-Society, Philadelphia, PA, Aug 17-21, 2008. Published in: Abstracts of papers of the American Chemical Society, Vol.236 ISSN 0065-7727.
Xin, Meite and Bugg, Tim (2008) Evidence from mechanistic probes for distinct hydroperoxide rearrangement mechanisms in the intradiol and extradiol catechol dioxygenases. Journal of the American Chemical Society, Vol.130 (No.31). pp. 10422-10430. doi:10.1021/ja8029569 ISSN 0002-7863.
Dodd, Charlotte E., Johnson, Benjamin R. G., Jeuken, Lars J. C., Bugg, Tim, Bushby, Richard J. and Evans, Stephen D. (2008) Native E. coli inner membrane incorporation in solid-supported lipid bilayer membranes. Biointerphases, Vol.3 (No.2). FA59-FA67. doi:10.1116/1.2896113 ISSN 1559-4106.
Bugg, Tim and Ramaswamy, S. (2008) Non-heme iron-dependent dioxygenases : unravelling catalytic mechanisms for complex enzymatic oxidations. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 134-140. ISSN 1367-5931 doi:10.1016/j.cbpa.2007.12.007
Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200 ISSN 0021-9258.
Mainardi, Jean-Luc, Villet, Regis, Bugg, Tim, Mayer, Claudine and Arthur, Michel (2008) Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria. FEMS Microbiology Reviews, Vol.32 (No.2). pp. 386-408. ISSN 0168-6445 doi:10.1111/j.1574-6976.2007.00097.x
Bouhss, Ahmed, Trunkfield, Amy E., Bugg, Tim and Mengin-Lecreulx, Dominique (2008) The biosynthesis of peptidoglycan lipid-linked intermediates. FEMS Microbiology Reviews, Vol.32 (No.2). pp. 208-233. ISSN 0168-6445 doi:10.1111/j.1574-6976.2007.00089.x
Li, C. (Chen), Hassler, Melanie and Bugg, Tim (2008) Catalytic promiscuity in the alpha/beta-hydrolase superfamily: Hydroxamic acid formation, C-C bondformation, ester and thioester hydrolysis in the C-C hydrolase family. Chembiochem, Vol.9 (No.1). pp. 71-76. doi:10.1002/cbic.200700428 ISSN 1439-4227.
Lam, Wai-Ho, Rychli, Kathrin and Bugg, Tim (2008) Cation of a novel beta-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. Organic & Biomolecular Chemistry, Vol.6 (No.11). pp. 1912-1917. doi:10.1039/b802585a ISSN 1477-0520.
Lam, Wai-Ho, Rychli, Kathrin and Bugg, Tim (2008) Identification of a novel Ξ²-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. Organic & Biomolecular Chemistry, Vol.6 (No.11). pp. 1912-1917. doi:10.1039/b802585a ISSN 1477-0520.
Xu, Xiu-Hua, Trunkfield, Amy E., Bugg, Tim and Qing, Feng-Ling (2008) Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors. Organic & Biomolecular Chemistry, Vol.6 (No.1). pp. 157-161. doi:10.1039/b713068f ISSN 1477-0520.
Rea, Dean, FΓΌlΓΆp, Vilmos, Bugg, Tim and Roper, David I. (2007) Structure and mechanism of HpcH : a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.373 (No.4). pp. 866-876. doi:10.1016/j.jmb.2007.06.048 ISSN 0022-2836.
Xin, Meite and Bugg, Tim (2007) BIOL 223-Mechanistic studies of the intradiol catechol dioxygenases. In: UNSPECIFIED. Published in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234 ISSN 0065-7727.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.
Li, Jian-Jun and Bugg, Tim (2007) Investigation of a general base mechanism for ester hydrolysis in C-C hydrolase enzymes of the alpha/beta-hydrolase superfamily : a novel mechanism for the serine catalytic triad. Organic & Biomolecular Chemistry, Volume 5 (Number 3). pp. 507-513. doi:10.1039/b615605c ISSN 1477-0520.
Schlosrich, Janne, Eley, Kirstin L., Crowley, Patrick J. and Bugg, Tim (2006) Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: Identification of mutants with intradiol oxidative cleavage activity. CHEMBIOCHEM, 7 (12). pp. 1899-1908. doi:10.1002/cbic.200600296 ISSN 1439-4227.
Li, Chen, Li, Jian-Jun, Montgomery, Mark G., Wood, Stephen P. and Bugg, Tim (2006) Catalytic role for Arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD. BIOCHEMISTRY, 45 (41). pp. 12470-12479. doi:10.1021/bi061253t ISSN 0006-2960.
Li, Jian-Jun, Li, Chen, Blindauer, Claudia A. and Bugg, Tim (2006) Evidence for a gem-diol reaction intermediate in bacterial C-C hydrolase enzymes BphD and MhpC from C-13 NMR spectroscopy. BIOCHEMISTRY, 45 (41). pp. 12461-12469. doi:10.1021/bi0612519 ISSN 0006-2960.
Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., De Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Timothy D. H. (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5. Molecular BioSystems, 2 (10). pp. 484-491. doi:10.1039/b607908c ISSN 1742-206X.
Mendel, Sharon, Holbourn, Joanne M., Schouten, James A. and Bugg, Tim (2006) Interaction of the transmembrane domain of lysis protein E from bacteriophage phi X174 with bacterial translocase MraY and peptidyi-prolyl isomerase SlyD. MICROBIOLOGY-SGM, 152 (Part 10). pp. 2959-2967. doi:10.1099/mic.0.28776-0 ISSN 1350-0872.
Bugg, Timothy D. H., Lloyd, Adrian J. and Roper, David I. (2006) Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. Infectious Disorders - Drug Targets, 6 (2). pp. 85-106. doi:10.2174/187152606784112128 ISSN 1871-5265.
Paradis-Bleau , Catherine, Beaumont, Mélanie , Boudreault, Lydia , Lloyd, Adrian, Sanschagrina, François , Bugg, Tim and Levesquea, Roger C. (2006) Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. Peptides, Volume 27 (Number 7). pp. 1693-1700. doi:10.1016/j.peptides.2006.01.017 ISSN 0196-9781.
Lloyd, Adrian J., Brandish, Philip E., Gilbey, Andrea M. and Bugg, Timothy D. H. (2004) Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli : catalytic role of conserved aspartic acid residues. Journal of bacteriology, 186 (6). pp. 1747-57. doi:10.1128/JB.186.6.1747-1757.2004 ISSN 0021-9193.
This list was generated on Fri Mar 29 10:22:17 2024 GMT.