2020

Hill, Emily, Dale, Nicholas and Wall, Mark J. (2020) Moderate changes in CO2 modulate the firing of neurons in the VTA and substantia nigra. iScience . 101343. doi:10.1016/j.isci.2020.101343

Bolborea, Matei, Pollatzek, Eric, Benford, Heather, Sotelo-Hitschfeld, Tamara and Dale, Nicholas (2020) Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network. Proceedings of the National Academy of Sciences of the United States of America, 117 (25). pp. 14473-14481. 201919887. doi:10.1073/pnas.1919887117

2019

Dospinescu, Valentin-Mihai, Nijjar, Sarbjit, Spanos, Fokion, Cook, Jonathan P., de Wolf, Elizabeth, Biscotti, Maria Assunta, Gerdol, Marco and Dale, Nicholas (2019) Structural determinants of CO2-sensitivity in the β connexin family suggested by evolutionary analysis. Communications Biology, 2 (1). 331 . doi:10.1038/s42003-019-0576-2

Cook, Jonathan P., de Wolf, Elizabeth and Dale, Nicholas (2019) Cx26 keratitis ichthyosis deafness syndrome mutations trigger alternative splicing of Cx26 to prevent expression and cause toxicity in vitro. Royal Society Open Science , 6 (8). 191128. doi:10.1098/rsos.191128

Dale, Nicholas, Tian, Faming, Sagoo, Ravjit, Phillips, Norman, Imray, C. (Chris) and Roffe, Christine (2019) Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling . doi:10.1007/s11302-019-09647-4 (In Press)

Martin, Alexander J., Dale, Nicholas, Imray, Christopher H. E., Roffe, Christine, Smith, Craig J., Tian, Faming and Price, Christopher I. (2019) The association between early neurological deterioration and whole blood purine concentration during acute stroke. Biomarker Research, 7 (1). doi:10.1186/s40364-019-0158-y

2017

Tian, Faming, Bibi, Fakhra, Dale, Nicholas and Imray, C. (Chris) (2017) Blood purine measurements as a rapid real-time indicator of reversible brain ischaemia. Purinergic Signalling, 13 (4). pp. 521-528. doi:10.1007/s11302-017-9578-z

Lazutkaite, Greta, Soldà, Alice, Lossow, Kristina, Meyerhof, Wolfgang and Dale, Nicholas (2017) Amino acid sensing in hypothalamic tanycytes via umami taste receptors. Molecular Metabolism, 6 (11). pp. 1480-1492. doi:10.1016/j.molmet.2017.08.015

Benford, Heather Elizabeth, Bolborea, Matei, Pollatzek, Eric, Lossow, Kristina, Hermans-Borgmeyer, Irm, Liu, Beihui, Meyerhof, Wolfgang, Kasparov, Sergey and Dale, Nicholas (2017) A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes. Glia, 65 (5). pp. 773-789. doi:10.1002/glia.23125

de Wolf, Elizabeth, Cook, Jonathan and Dale, Nicholas (2017) Evolutionary adaptation of the sensitivity of connexin26 hemichannels to CO2. Proceedings of the Royal Society B: Biological Sciences, 284 . doi:10.1098/rspb.2016.2723

2016

de Wolf, Elizabeth, van de Wiel, Joseph, Cook, Jonathan and Dale, Nicholas (2016) Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro. Physiological Reports, 4 (22). e13038.

Bjorness, T. E., Dale, Nicholas, Mettlach, G., Sonneborn, A., Sahin, B., Fienberg, A. A., Yanagisawa, M., Bibb, J. A. and Greene, R. W. (2016) An adenosine-mediated Glial-Neuronal circuit for homeostatic sleep. Journal of Neuroscience, 36 (13). pp. 3709-3721. doi:10.1523/JNEUROSCI.3906-15.2016

2015

Burnstock, Geoffrey and Dale, Nicholas (2015) Purinergic signalling during development and ageing. Purinergic Signalling, 11 (3). pp. 277-305. doi:10.1007/s11302-015-9452-9

Lopatář, Ján, Dale, Nicholas and Frenguelli, Bruno G. (2015) Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations. Neuropharmacology, Volume 93 . pp. 219-228. doi:10.1016/j.neuropharm.2015.01.014

Bjerring, Peter Nissen, Dale, Nicholas and Larsen, Fin Stolze (2015) Acute hyperammonemia and systemic inflammation is associated with increased extracellular brain adenosine in rats : a biosensor study. Neurochemical Research, Volume 40 (Number 2). pp. 258-264. doi:10.1007/s11064-014-1357-4

Meigh, Louise, Cook, Daniel Sean, Zhang, Jie and Dale, Nicholas (2015) Rational design of new NO and redox sensitivity into connexin26 hemichannels. Open Biology, Volume 5 (Number 2). pp. 1-9. Article number 140208. doi:10.1098/rsob.140208

2014

Meigh, Louise, Hussain, Naveed, Mulkey, Daniel K. and Dale, Nicholas (2014) Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2. eLife, Volume 3 . Article number e04249. doi:10.7554/eLife.04249

Tian, Faming, Greplová, Marta, Frébort, Ivo, Dale, Nicholas and Napier, R. (Richard) (2014) A highly selective biosensor with nanomolar sensitivity based on cytokinin dehydrogenase. PLoS One, Volume 9 (Number 3). Article number e90877. doi:10.1371/journal.pone.0090877

Sims, Robert E. and Dale, Nicholas (2014) Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase : an in vitro rat study. PLoS One, Volume 9 (Number 1). Article number e87481. doi:10.1371/journal.pone.0087481

2013

Wall, Mark J. and Dale, Nicholas (2013) Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus. The Journal of Physiology, Volume 591 (Number 16). pp. 3853-3871. doi:10.1113/jphysiol.2013.253450

Sims, Robert E., Wu, Houdini Ho Tin and Dale, Nicholas (2013) Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study. PLoS One, Vol.8 (No.1). e53814. doi:10.1371/journal.pone.0053814

Meigh, Louise, Greenhalgh, Sophie A., Rodgers, Thomas L., Cann, Martin J., Roper, David I. and Dale, Nicholas (2013) CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits. eLife, Volume 2 . Article number e01213. doi:10.7554/eLife.01213

Bolborea, Matei and Dale, Nicholas (2013) Hypothalamic tanycytes : potential roles in the control of feeding and energy balance. Trends in Neurosciences, Vol.36 (No.2). pp. 91-100. doi:10.1016/j.tins.2012.12.008

2012

Masse, Karine and Dale, Nicholas (2012) Purines as potential morphogens during embryonic development. Purinergic Signalling, Vol.8 (No.3). pp. 503-521. doi:10.1007/s11302-012-9290-y

Schmitt, L. Ian, Sims, Robert E., Dale, Nicholas and Haydon, Philip G (2012) Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine. The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol.32 (No.13). pp. 4417-4425. doi:10.1523/JNEUROSCI.5689-11.2012

Klyuch, Boris P., Dale, Nicholas and Wall, Mark J. (2012) Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release. Journal of Neuroscience, Vol.32 (No.11). pp. 3842-3847. doi:10.1523/JNEUROSCI.6052-11.2012

Dale, Nicholas and Frenguelli, Bruno G. (2012) Measurement of purine release with microelectrode biosensors. Purinergic Signalling, Vol.8 (No.S1). pp. 27-40. doi:10.1007/s11302-011-9273-4

Klyuch, Boris P., Dale, Nicholas and Wall, Mark J. (2012) Receptor-mediated modulation of activity-dependent adenosine release in rat cerebellum. Neuropharmacology, Vol.62 (No.2). pp. 815-824. doi:10.1016/j.neuropharm.2011.09.007

Yang, G. K., Squires, Paul E., Tian, Faming, Kieffer, T. J., Kwok, Y. N. and Dale, Nicholas (2012) Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets. Islets, Vol.4 (No.1). doi:10.4161/isl.4.1.19037

Dale, Nicholas (2012) A classic review on extracellular ATP and its signalling functions that helped to define the field's agenda for many years. Biochemical Journal, Volume 2012 (Number 1). c3-c6. doi:10.1042/BJ20121145

2011

Huckstepp, Robert T. R. and Dale, Nicholas (2011) Redefining the components of central CO2 chemosensitivity : towards a better understanding of mechanism. The Journal of Physiology, 589 (23). pp. 5561-5579. doi:10.1113/jphysiol.2011.214759

Kowalska, Marta, Tian, Faming, Šmehilová, Mária, Galuszka, Petr, Frébort, Ivo, Napier, R. (Richard) and Dale, Nicholas (2011) Prussian Blue acts as a mediator in a reagentless cytokinin biosensor. Analytica Chimica Acta, Vol.701 (No.2). pp. 218-223. doi:10.1016/j.aca.2011.06.018

Lopatář, Ján, Dale, Nicholas and Frenguelli, Bruno G. (2011) Minor contribution of ATP P2 receptors to electrically-evoked electrographic seizure activity in hippocampal slices : evidence from purine biosensors and P2 receptor agonists and antagonists. Neuropharmacology, Vol.61 (No.1-2). pp. 25-34. doi:10.1016/j.neuropharm.2011.02.011

Frayling, Cameron, Britton, Ruth and Dale, Nicholas (2011) ATP-mediated glucosensing by hypothalamic tanycytes. Journal of Physiology, Volume 589 (Number 9). pp. 2275-2286. doi:10.1113/jphysiol.2010.202051

Dale, Nicholas (2011) Purinergic signaling in hypothalamic tanycytes : potential roles in chemosensing. Seminars in Cell and Developmental Biology, Vol.22 (No.2). pp. 237-244. doi:10.1016/j.semcdb.2011.02.024

Klyuch, Boris P., Richardson, Magnus J. E., Dale, Nicholas and Wall, Mark J. (2011) The dynamics of single spike-evoked adenosine release in the cerebellum. Journal of Physiology, The, Vol.589 (No.2). pp. 283-295. doi:10.1113/jphysiol.2010.198986

Huckstepp, Robert T. R. and Dale, Nicholas (2011) CO2-dependent opening of an inwardly rectifying K+ channel. Pfluegers Archiv, Vol.461 (No.3). pp. 337-344. doi:10.1007/s00424-010-0916-z

2010

Huckstepp, Robert T. R., Eason, Robert, Sachdev, Anshu and Dale, Nicholas (2010) CO2-dependent opening of connexin 26 and related beta connexins. Journal of Physiology, Vol.588 (No.20). pp. 3921-3931. doi:10.1113/jphysiol.2010.192096

Huckstepp, Robert T. R., Bihi, Rachid Id, Eason, Robert, Spyer, K. Michael, Dicke, Nikolai, Willecke, Klaus, Marina, Nephtali, Gourine, Alexander V. and Dale, Nicholas (2010) Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. Journal of Physiology, Vol.588 (No.20). pp. 3901-3920. doi:10.1113/jphysiol.2010.192088

Forsythe, Ian D., Grubb, Blair D. and Dale, Nicholas (2010) An introduction to Peter Stanfield's festschrift. Journal of Physiology, The, Vol.588 (No.17). pp. 3139-3140. doi:10.1113/jphysiol.2010.196006

Wall, Mark J., Eason, Robert and Dale, Nicholas (2010) Biosensor measurement of purine release from cerebellar cultures and slices. Purinergic Signalling, Vol.6 (No.3). pp. 339-348. doi:10.1007/s11302-010-9185-8

Tian, Faming, Wu, Wenjue, Broderick, Michael, Vamvakaki, Vicky, Chaniotakis, Nikos and Dale, Nicholas (2010) Novel microbiosensors prepared utilizing biomimetic silicification method. Biosensors and Bioelectronics, Vol.25 (No.11). pp. 2408-2413. doi:10.1016/j.bios.2010.03.015

Masse, Karine, Bhamra, Surinder, Allsop, Gavin, Dale, Nicholas and Jones, Elizabeth A. (2010) Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction. International Journal of Developmental Biology, Vol.54 (No.1). pp. 181-193. doi:10.1387/ijdb.092879km

2009

Dale, Nicholas and Frenguelli, Bruno G. (2009) Release of adenosine and ATP during ischemia and epilepsy. Current Neuropharmacology, Vol.7 (No.3). pp. 160-179. doi:10.2174/157015909789152146

Tian, Faming, Gourine, Alexander V., Huckstepp, Robert T. R. and Dale, Nicholas (2009) A microelectrode biosensor for real time monitoring of L-glutamate release. Analytica Chimica Acta, Vol.645 (No.1-2). pp. 86-91. doi:10.1016/j.aca.2009.04.048

Etherington, Lori-An V., Patterson, Graham E., Meechan, Louise, Boison, Detlev, Irving, Andrew J., Dale, Nicholas and Frenguelli, Bruno G. (2009) Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacology, Vol.56 (No.2). pp. 429-437. doi:10.1016/j.neuropharm.2008.09.016

Dale, Nicholas (2009) Novel mechanisms of central chemosensitivity. In: The XXXVI International Congress of Physiological Sciences (IUPS2009), Kyoto, Japan, July 27-August 01, 2009. Published in: Journal of Physiological Sciences, Vol.59 (Suppl. 1). p. 73. ISSN 1880-6546.

2008

Wall, Mark J. and Dale, Nicholas (2008) Activity-dependent release of Adenosine: a critical re-evaluation of mechanism. Current Neuropharmacology, Vol.6 (No.4). pp. 329-337. doi:10.2174/157015908787386087

Wall, Mark J., Wigmore, Geoffery, Lopatář, Ján, Frenguelli, Bruno G. and Dale, Nicholas (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, Vol.55 (No.7). pp. 1251-1258. doi:10.1016/j.neuropharm.2008.08.005

Gourine, Alexander V., Dale, Nicholas, Korsak, Alla, Llaudet, Enrique, Tian, Faming, Huckstepp, Robert T. R. and Spyer, K. Michael (2008) Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway. The Journal of Physiology, Volume 586 (Number 16). pp. 3963-3978. doi:10.1113/jphysiol.2008.154567

Dale, Nicholas (2008) Dynamic ATP signalling and neural development. The Journal of Physiology, Vol.586 (No.10). pp. 2429-2436. doi:10.1113/jphysiol.2008.152207

Dale, Nicholas (2008) From chemoreception to eye development - fundamental roles of ATP signalling. In: Purines 2008 Meeting, Copenhagen, Denmark, 29 June – 2 July 2008. Published in: Purinergic Signalling, Vol.4 (Suppl.1). S1-S1. ISSN 1573-9546.

2007

Gourine, Alexander V., Dale, Nicholas, Llaudet, Enrique, Poputnikov, Dmitry M., Spyer, K. Michael and Gourine, Valery N. (2007) Release of ATP in the central nervous system during systemic inflammation : real-time measurement in the hypothalamus of conscious rabbits. Journal of Physiology, Vol.585 (No.1). pp. 305-316. doi:10.1113/jphysiol.2007.143933

Masse, Karine, Bhamra, Surinder, Eason, Robert, Dale, Nicholas and Jones, Elizabeth A. (2007) Purine-mediated signalling triggers eye development. Nature, Vol.449 (No.7165). pp. 1058-1062. doi:10.1038/nature06189

Tian, Faming, Llaudet, Enrique and Dale, Nicholas (2007) Ruthenium purple-mediated microelectrode biosensors based on sol-gel film. Analytical Chemistry, Vol.79 (No.17). pp. 6760-6766. doi:10.1021/ac070822f

Wall, Mark J., Atterbury, Alison and Dale, Nicholas (2007) Control of basal extracellular adenosine concentration in rat cerebellum. Journal of Physiology, Vol.582 (No.1). pp. 137-151. doi:10.1113/jphysiol.2007.132050

Wall, Mark J. and Dale, Nicholas (2007) Auto-inhibition of rat parallel fibre-Purkinje cell synapses by activity-dependent adenosine release. Journal of Physiology, Vol.581 (No.2). pp. 553-565. doi:10.1113/jphysiol.2006.126417

Frenguelli, Bruno G., Wigmore, Geoffrey, Llaudet, Enrique and Dale, Nicholas (2007) Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. Journal of Neurochemistry, Vol.101 (No.5). pp. 1400-1413. doi:10.1111/j.1471-4159.2006.04425.x

Kung, David, Beylin, Alexander, Miekisiak, Grzegorz Jerzy, Sandler, Adam Lance, Yoo, JiSuk Kristen, Dale, Nicholas and Winn, H. Richard (2007) Changes in brain extracellular adenosine (ADOe) during acute hypoxia. In: Experimental Biology 2007 Annual Meeting, Washington, DC, April 28-May 02, 2007. Published in: FASEB Journal, Vol.21 (No.6). A1387-A1387. ISSN 0892-6638.

2006

Dale, Nicholas (2006) The acid nature of CO2-evoked adenosine release in the CNS. JOURNAL OF PHYSIOLOGY-LONDON, 574 (3). p. 633. doi:10.1113/jphysiol.2006.115022

Masse, Karine, Eason, Robert, Bhamra, Surinder, Dale, Nicholas and Jones, Elizabeth A. (2006) Comparative genomic and expression analysis of the conserved NTPDase gene family in Xenopus. Genomics, Vol.87 (No.3). pp. 366-381. doi:10.1016/j.ygeno.2005.11.003

2005

Gourine, Alexander V., Llaudet, Enrique, Dale, Nicholas and Spyer, K. Michael (2005) Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response. Journal of Neuroscience, Vol.25 (No.5). pp. 1211-1218. doi:10.1523/JNEUROSCI.3763-04.2005

2002

Dale, Nicholas (2002) Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? Journal of Neuroscience, Vol.22 (No.23). pp. 10461-10469.

2001

Pearson, Tim, Nuritova, Feruza, Caldwell, Darren, Dale, Nicholas and Frenguelli, Bruno G. (2001) A depletable pool of adenosine in area CA1 of the rat hippocampus. Journal of Neuroscience, Vol.21 (No.7). pp. 2298-2307.