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Number of items: 98.
2023
Micelli, Carmina, Dai, Yunfei, Raustad, Nicole, Isberg, Ralph R., Dowson, Christopher G., Lloyd, Adrian J., Geisinger, Edward, Crow, Allister and Roper, David I. (2023) A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape. Proceedings of the National Academy of Sciences of the United States of America, 120 (8). e2215237120. doi:10.1073/pnas.2215237120 ISSN 0027-8424.
2022
Stefanini, Irene, Stoakes, Emily, Wu, Houdini H. T., Xu-McCrae, Li, Hussain, Abid, Moat, John, Dowson, Christopher G., David, Miruna D. and Constantinidou, Chrystala (2022) Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility. Microbiology Spectrum, 10 (6). e01827-22. doi:10.1128/spectrum.01827-22 ISSN 2165-0497.
Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo and Dowson, Christopher G. (2022) Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1). pp. 165-179. doi:10.1093/plphys/kiac176 ISSN 1532-2548.
Ghionis, A., Barker, T. and Dowson, Christopher G. (2022) AMR policy dialogue : driving innovative solutions for antimicrobial discovery. Coventry: University of Warwick.
2021
Tran, Wendy, Kusay, Ali S., Hawkins, Paige M. E., Cheung, Chen-Yi, Nagalingam, Gayathri, Pujari, Venugopal, Ford, Daniel J., Stoye, Alexander, Ochoa, Jessica L., Audette, Rebecca E. et al.
(2021)
Synthetic sansanmycin analogues as potent mycobacterium tuberculosis translocase I inhibitors.
Journal of Medicinal Chemistry, 64
(23).
pp. 17326-17345.
doi:10.1021/acs.jmedchem.1c01407
ISSN 1520-4804.
Cama, J., Leszczynski, R., Tang, P. K., Khalid, A., Lok, V., Dowson, Christopher G. and Ebata, A. (2021) To push or to pull? In a post-COVID world, supporting and incentivizing antimicrobial drug development must become a governmental priority. ACS Infectious Diseases, 7 (8). pp. 2029-2042. doi:10.1021/acsinfecdis.0c00681 ISSN 2373-8227.
Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J., Boyle, Grant A., Paterson, Neil G., McAuley, Katherine E., Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, JΓΌrgen, Chibale, Kelly, Schofield, Christopher J. and Dowson, Christopher G. (2021) High-throughput crystallography reveals boron-containing inhibitors of a Penicillin-binding protein with di- and tricovalent binding modes. Journal of Medicinal Chemistry, 64 (15). pp. 11379-11394. doi:10.1021/acs.jmedchem.1c00717 ISSN 0022-2623.
York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, FΓΌlΓΆp, Vilmos, Dowson, Christopher G., Khalid, Syma and Roper, David I. (2021) Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7). pp. 731-742. doi:10.1016/j.str.2021.03.001 ISSN 0969-2126.
Klug, Dana M., Idiris, Fahima I. M., Blaskovich, Mark A. T., von Delft, Frank, Dowson, Christopher G., Kirchhelle, Claas, Roberts, Adam P., Singer, Andrew C. and Todd, Matthew H. (2021) There is no market for new antibiotics : this allows an open approach to research and development. Wellcome Open Research, 6 . 146. doi:10.12688/wellcomeopenres.16847.1 ISSN 2398-502X.
Aggarwal, Surya D. , Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R and Hiller, N Luisa (2021) A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14). e2018089118. doi:10.1073/pnas.2018089118 ISSN 0027-8424.
2020
Styles, Kathryn, Thummeepak, Rapee, Leungtongkam, Udomluk, Smith, Sophie, Christie, Gabrielle S., Millard, Andrew D., Moat, John, Dowson, Christopher G., Wellington, Elizabeth M. H., Sitthisak, Sutthirat and Sagona, Antonia P. (2020) Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii. Antibiotics, 9 (4). 200. doi:10.3390/antibiotics9040200 ISSN 2079-6382.
Jacques, Laura C., Panagiotou, Stavros, Baltazar, Murielle, Senghore, Madikay, Khandaker, Shadia, Xu, Rong, Bricio-Moreno, Laura, Yang, Marie, Dowson, Christopher G., Everett, Dean B., Neill, Daniel R. and Kadioglu, Aras (2020) Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nature Communications, 11 (1). 1892 . doi:10.1038/s41467-020-15751-6 ISSN 2041-1723.
Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822 ISSN 0002-7863.
Kidd, Sarah L., Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias et al.
(2020)
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Chemical Science, 11
(39).
pp. 10792-10801.
doi:10.1039/D0SC01232G
ISSN 2041-6520.
2019
Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J. and Roper, David I. (2019) Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21). pp. 9703-9717. doi:10.1021/acs.jmedchem.9b01131 ISSN 0022-2623.
Bellini, Dom, Koekemoer, LizbΓ©, Newman, Hector and Dowson, Christopher G. (2019) Novel and improved crystal structures of H. influenzae, E. coli and P. aeruginosa penicillin-binding protein 3 (PBP3) and N. gonorrhoeae PBP2 : toward a better understanding of Ξ²-Lactam target-mediated resistance. Journal of Molecular Biology, 431 (18). pp. 3501-3519. doi:10.1016/j.jmb.2019.07.010 ISSN 0022-2836.
Hind, Charlotte K., Dowson, Christopher G., Sutton, J. Mark, Jackson, Thomas, Clifford, Melanie, Garner, R. Colin and Czaplewski, Lloyd (2019) Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy, 63 . e00769. doi:10.1128/AAC.00769-19 ISSN 0066-4804.
Hu, Qingfeng, Yu, Yan, Gu, Dongshi, Xie, Li, Chen, Xingrou, Xu, Ning, Ruan, Jennifer Jin, Dowson, Christopher G. and Ruan, Benfang Helen (2019) Precise Measurement of Time Dependent Cell Growth and Detection of Partial Drug Resistance in Infectious Microbial. ACS Infectious Diseases, 5 (7). pp. 1252-1263. doi:10.1021/acsinfecdis.9b00132 ISSN 2373-8227.
Massarweh, Ahmad, Bosco, Michael, Chantret, Isabelle, LΓ©ger, Thibaut, Jamal, Layla, Roper, David I., Dowson, Christopher G., Busca, Patricia, Bouhss, Ahmed, Gravier-Pelletier, Christine and Moore, Stuart E. H. (2019) Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities. Molecules, 24 (11). 2135. doi:10.3390/molecules24112135 ISSN 1420-3049.
Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, CalvopiΓ±a, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J. and Brem, JΓΌrgen (2019) Profiling interactions of vaborbactam with metallo-Ξ²-lactamases. Bioorganic & Medicinal Chemistry Letters, 29 (15). pp. 1981-1984. doi:10.1016/j.bmcl.2019.05.031 ISSN 0960-894X.
Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P., Aimon, Anthony, Amitai, Gabriel, Bellini, Dom et al.
(2019)
Rapid covalent-probe discovery by electrophile-fragment screening.
Journal of the American Chemical Society, 141
(22).
pp. 8951-8968.
doi:10.1021/jacs.9b02822
ISSN 0002-7863.
Dougan, Gordon, Dowson, Chris and Overington, John (2019) Meeting the discovery challenge of drug-resistant infections : progress and focusing resources. In: Next Generation Antibiotic Discovery Symposium, Jan 2018. Published in: Drug Discovery Today, 24 (2). pp. 452-461. doi:10.1016/j.drudis.2018.11.015 ISSN 1359-6446.
2018
Γster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, JΓ³zef R. (2018) Structural studies suggest aggregation as one of the modes of action for teixobactin. Chemical Science, 9 (47). pp. 8850-8859. doi:10.1039/c8sc03655a ISSN 2041-6520.
Γster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, JΓ³zef R. (2018) Data for Structural studies suggest aggregation as one of the modes of action for teixobactin. [Dataset]
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16). pp. 7330-7344. doi:10.1021/acs.jmedchem.8b00906 ISSN 1520-4804.
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Data for Biguanide iridium(III) complexes with potent antimicrobial activity. [Dataset]
Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma and Roper, David I. (2018) The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2 . pp. 54-66. doi:10.1016/j.tcsw.2018.06.002 ISSN 2468-2330.
Ratamero, Erick Martins, Bellini, Dom, Dowson, Christopher G. and RΓΆmer, Rudolf A. (2018) Touching proteins with virtual bare hands : visualizing proteinβdrug complexes and their dynamics in self-made virtual reality using gaming hardware. Journal of Computer-Aided Molecular Design, 32 (6). pp. 703-709. doi:10.1007/s10822-018-0123-0 ISSN 1573-4951.
Hrast, Martina, JukiΔ, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, HΓ©lΓ¨ne and Gobec, Stanislav (2018) In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB. Chemical Biology & Drug Design, 91 (6). pp. 1101-1112. doi:10.1111/cbdd.13172 ISSN 1747-0285.
2017
Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, FΓΌlΓΆp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S. and Roper, David I. (2017) Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1). 1939 . doi:10.1038/s41467-017-02118-7 ISSN 2041-1723.
Sychantha, David, Jones, Carys S., Little, Dustin J., Moynihan, Patrick J., Robinson, Howard, Galley, Nicola F., Roper, David I., Dowson, Christopher G., Howell, P. Lynne and Clarke, Anthony J. (2017) In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLOS Pathogens, 13 (10). e1006667. doi:10.1371/journal.ppat.1006667 ISSN 1553-7374.
Kuroki, Agnès, Sangwan, Parveen, Qu, Yue, Peltier, Raoul, Sanchez-Cano, Carlos, Moat, John, Dowson, Christopher G., Williams, Elizabeth G. L., Locock, Katherine E. S., Hartlieb, Matthias and Perrier, Sébastien (2017) Sequence control as a powerful tool for improving the selectivity of antimicrobial polymers. ACS Applied Materials & Interfaces, 9 (46). pp. 40117-40126. doi:10.1021/acsami.7b14996 ISSN 1944-8244.
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 . 14414 . doi:10.1038/ncomms14414 ISSN 2041-1723.
Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, KoΕ‘mrlj, Janez and Dowson, Christopher G. (2017) Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127 . pp. 223-234. doi:10.1016/j.ejmech.2016.12.060 ISSN 0223-5234.
2016
Nelson, E Andrea, Wright-Hughes, Alexandra, Brown, Sarah, Lipsky, Benjamin A, Backhouse, Michael, Bhogal, Moninder, Ndosi, Mwidimi, Reynolds, Catherine, Sykes, Gill, Dowson, Christopher G., Edmonds, Michael, Vowden, Peter, Jude, Edward B., Dickie, Tom and Nixon, Jane (2016) Concordance in diabetic foot ulceration : a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers. Health Technology Assessment, 20 (82). doi:10.3310/hta20820 ISSN 1366-5278.
Dowson, Christopher G. and OβReilly, Steven (2016) DNA methylation in fibrosis. European Journal of Cell Biology, 95 (9). pp. 323-330. doi:10.1016/j.ejcb.2016.06.003 ISSN 0171-9335.
AraΓΊjo, Carlos Leonardo de A., Dias, Larissa M., Veras, Adonney A. O., Alves, Jorianne T. C., Cavalcante, Ana LΓdia Q., Dowson, Christopher G., Azevedo, Vasco, Ramos, Rommel T. J., Silva, Artur and Carneiro, Adriana R. (2016) Whole-genome sequence of Corynebacterium pseudotuberculosis 262 biovar equi isolated from cow milk. Genome Announcements, 4 (2). e00176. doi:10.1128/genomeA.00176-16 ISSN 2169-8287.
Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A. and Besra, Gurdyal S. (2016) Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6 . 23191. doi:10.1038/srep23191 ISSN 2045-2322.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
2015
Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X. et al.
(2015)
Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.
Nature Communications, 6
.
pp. 1-11.
7719.
doi:10.1038/ncomms8719
ISSN 2041-1723.
2013
Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.
Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.
Rushton, Laura, Sass, Andrea, Baldwin, Adam, Dowson, Christopher G., Donoghue, Denise and Mahenthiralingam, Eshwar (2013) Key role for efflux in the preservative susceptibility and adaptive resistance of burkholderia cepacia complex bacteria. Antimicrobial Agents and Chemotherapy, 57 (7). pp. 2972-2980. doi:10.1128/AAC.00140-13 ISSN 0066-4804.
Dobrzanska, Dorota A., Cooper, A. (Amy), Dowson, Christopher G., Evans, Stephen D., Fox, David J., Johnson, Benjamin R., Biggs, Caroline I., Randev, Rajan, Stec, Helena M., Taylor, Paul C. and Marsh, Andrew (2013) Oxidation of tertiary amine-derivatized surfaces to control protein adhesion. Langmuir, Volume 29 (Number 9). pp. 2961-2970. doi:10.1021/la4003719 ISSN 0743-7463.
Castro, Thiago L. P., Seyffert, Nubia, Ramos, Rommel T. J., Barbosa, Silvanira, Carvalho, Rodrigo D. O., Pinto, Anne Cybelle, Carneiro, Adriana Ribeiro, Silva, Wanderson Marques, Pacheco, Luis G. C., Downson, Christopher G., Schneider, Maria P. C., Miyoshi, Anderson, Azevedo, V. (Vasco) and Silva, Artur (2013) Ion torrent-based transcriptional assessment of a Corynebacterium pseudotuberculosis equi strain reveals denaturing high-performance liquid chromatography a promising rRNA depletion method. Microbial Biotechnology, Volume 6 (Number 2). pp. 168-177. doi:10.1111/1751-7915.12020 ISSN 1751-7907.
Ruane, Karen M., Lloyd, Adrian J., Fülâp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa and Roper, David I. (2013) Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, Volume 288 (Number 46). Article number 33439. doi:10.1074/jbc.M113.508135 ISSN 0021-9258.
2012
Viguetti, S. Z., Pacheco, L. G. C., Santos, L. S., Soares, S. C., Bolt, F., Baldwin, Adam, Dowson, Christopher G., Rosso, M. L., Guiso, N., Miyoshi, A., Hirata, R., Mattos-Guaraldi, A. L. and Azevedo, V. (2012) Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil. Epidemiology and Infection, Volume 140 (Number 4). pp. 617-620. doi:10.1017/S0950268811000963 ISSN 0950-2688.
Dobrzanska, Dorota A., Cooper, Amy L., Dowson, Christopher G., Evans, Stephen D., Haynes, Tommy, Johnson, Benjamin R. G., Stec, Helena M., Taylor, Paul C. and Marsh, Andrew (2012) Protein-adhesive and protein-resistant functionalized silicon surfaces. Langmuir . (Submitted)
Hassan, S. S., Schneider, M. P. C., Ramos, R. T. J., Carneiro, A. R., Ranieri, A., Guimaraes, L. C., Ali, A., Bakhtiar, S. M., Pereira, U. d. P., dos Santos, A. R. et al.
(2012)
Whole-Genome Sequence of Corynebacterium pseudotuberculosis Strain Cp162, Isolated from Camel.
Journal of Bacteriology, Vol. 194
(No. 20).
pp. 5718-5719.
doi:10.1128/JB.01373-12
ISSN 0021-9193.
Pacheco, Luis G. C., Castro, Thiago L. P., Carvalho, Rodrigo D. O., Moraes, Pablo M., Dorella, Fernanda A., Carvalho, NatΓ‘lia B., Slade, Susan E., Scrivens, James H., Feelisch, Martin, Meyer, Roberto, Miyoshi, Anderson, Oliveira, SΓ©rgio C., Dowson, Christopher G. and Azevedo, Vasco (2012) A role for sigma factor ΟE in corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress. Frontiers in Microbiology, Volume 3 . Article number 126. doi:10.3389/fmicb.2012.00126 ISSN 1664-302X.
2011
McDowell, A. (Andrew), Gao, Anna, Barnard, E. (Emma), Fink, Colin, Murray, Philip I., Dowson, Christopher G., Nagy, I. (IstvΓ‘n), Lambert, Peter A. and Patrick, Sheila (2011) A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens. Microbiology, Vol.157 (No.7). pp. 1990-2003. doi:10.1099/mic.0.049676-0 ISSN 1350-0872.
Pacheco, Luis G. C., Slade, Susan E., Seyffert, NΓΊbia, Santos, Anderson R., Castro, Thiago L. P., Silva, Wanderson M., Santos, Agenor V., Santos, Simone G., Farias, Luiz M., Carvalho, Maria A. R., Pimenta, Adriano M. C., Meyer, Roberto, Silva, Artur, Scrivens, James H., Oliveira, SΓ©rgio C., Miyoshi, Anderson, Dowson, Christopher G. and Azevedo, Vasco (2011) A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis. BMC Microbiology, Vol.11 . article no. 12. doi:10.1186/1471-2180-11-12 ISSN 1471-2180.
Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006 ISSN 0167-7799.
Hattersley, John G., PΓ©rez-VelΓ‘zquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009 ISSN 01692607.
2010
Aaron, Shawn D., Vandemheen, Katherine L., Ramotar, Karam, Giesbrecht-Lewis, Tracy, Tullis, Elizabeth, Freitag, Andreas, Paterson, Nigel, Jackson, Mary, Lougheed, M. Diane, Dowson, Christopher G., Kumar, Vijay, Ferris, Wendy, Chan, Francis, Doucette, Steve and Fergusson, Dean (2010) Infection with transmissible strains of pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA: The Journal of the American Medical Association, Vol.304 (No.19). pp. 2145-2153. doi:10.1001/jama.2010.1665 ISSN 0098-7484.
Bolt, Frances, Cassiday, Pamela, Tondella, Maria Lucia, DeZoysa, Aruni, Efstratiou, Androulla, Sing, Andreas, Zasada, Aleksandra, Bernard, Kathryn, Guiso, Nicole, Badell, Edgar, Rosso, Marie-Laure, Baldwin, Adam and Dowson, Christopher G. (2010) Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae. Journal of Clinical Microbiology, Vol.48 (No.11). pp. 4177-4185. doi:10.1128/JCM.00274-10 ISSN 0095-1137.
Hall, Aron J., Cassiday, Pamela K., Bernard, Kathryn A., Bolt, Frances, Steigerwalt, Arnold G., Bixler, Danae, Pawloski, Lucia C., Whitney, Anne M., Iwaki, M., Baldwin, Adam, Dowson, Christopher G., Komiya, Takako, Takahashi, Motohide, Hinrikson, Hans P. and Tondella, Maria L. (2010) Novel Corynebacterium diphtheriae in domestic cats. Emerging Infectious Diseases , Vol.16 (No.4). doi:10.3201/eid1604.091107 ISSN 1080-6059.
Drevinek, Pavel, Baldwin, Adam, Lindenburg, Laurens, Joshi, Lovleen Tina, Marchbank, Angela, Vosahlikova, Sarka, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2010) Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping. Journal of Clinical Microbiology, Vol.48 (No.1). pp. 34-40. doi:10.1128/JCM.01433-09 ISSN 0095-1137.
2009
Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L. and Dowson, Christopher G. (2009) Cross-sectional and longitudinal multilocus sequence typing of Pseudomonas aeruginosa in cystic fibrosis sputum samples. Journal of Clinical Microbiology, Vol.47 (No.11). pp. 3444-3448. doi:10.1128/JCM.00459-09 ISSN 0095-1137.
Dumville, J. C., Worthy, G., Soares, M. O., Bland, J. M., Cullum, N., Dowson, Christopher G., Iglesias, C., McCaughan, D., Mitchell, J. L., Nelson, E. A. and Torgerson, D. J. (2009) VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers. Health Technology Assessment, Vol.13 (No.55). p. 1. ISSN 1366-5278 doi:10.3310/hta13550
Baldwin, Adam, Loughlin, Michael, Dr., Caubilla-Barron, Juncal, Kucerova, Eva, Manning, Georgina, Dowson, Christopher G. and Forsythe, S. J. (Steve J.) (2009) Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes. BMC Microbiology, Vol.9 (Article 223). doi:10.1186/1471-2180-9-223 ISSN 1471-2180.
Bearup, Daniel James, Evans, Neil D., Dowson, Christopher G. and Chappell, M. J. (Michael J.) (2009) Use of structural identifiability analysis to inform experimental design for enzyme kinetics. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book
Spilker, Theodore, Baldwin, Adam, Bumford, Amy, Dowson, Christopher G., Mahenthiralingam, Eshwar and LiPuma, John J. (2009) Expanded multilocus sequence typing for Burkholderia species. Journal of Clinical Microbiology, Vol.47 (No.8). pp. 2607-2610. doi:10.1128/JCM.00770-09 ISSN 0095-1137.
Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395 ISSN 0264-6021.
Holden, Matthew T. G., Hauser, Heidi, Sanders, Mandy, Ngo, Thi Hoa, Cherevach, Inna, Cronin, Ann, Goodhead, Ian, Mungall, Karen, Quail, Michael A., Price, Claire et al.
(2009)
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
PLOS One, Vol.4
(No.7).
doi:10.1371/journal.pone.0006072
ISSN 1932-6203.
Bernard, K., Schindle, S., Burdz, T., Wiebe, D., Reimer, A., Dowson, Christopher G., Bolt, F. and Baldwin, Adam (2009) The use of a multi locus sequence typing scheme to characterize Canadian isolates of Corynebacterium diphtheriae. In: 26th International Congress of Chemotherapy and Infection, Toronto, Canada, June 18-21, 2009. Published in: International Journal of Antimicrobial Agents, Vol.34 (Suppl. 2). S11-S11. doi:10.1016/S0924-8579(09)70177-3 ISSN 0924-8579.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028 ISSN 0968-0896.
Holden, Matthew T. G., Seth-Smith, Helena M. B., Crossman, Lisa C., Sebaihia, Mohammed, Bentley, Stephen D., Cerdeno-Tarraga, Ana M., Thomson, Nicholas R., Bason, Nathalie, Quail, Michael A., Sharp, Sarah et al.
(2009)
Author's correction to The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
Journal of Bacteriology, Vol.191
(No.8).
p. 2907.
ISSN 0021-9193
doi:10.1128/JB.00168-09
Clarke, Thomas B., Kawai, Fumihiro, Park, Sam-Yong, Tame, Jeremy R. H., Dowson, Christopher G. and Roper, David I. (2009) Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4. Biochemistry, Vol.48 (No.12). pp. 2675-2683. doi:10.1021/bi801993x ISSN 0006-2960.
VenUS II Team (Including: Dumville, Jo C., Worthy, Gill, Bland, J. Martin, Cullum, Nicky, Dowson, Christopher G., Iglesias, Cynthia, Mitchell, Joanne L., Nelson, E. Andrea, Soares, Marta O. and Torgerson, David J.). (2009) Larval therapy for leg ulcers (VenUS II): randomised controlled trial. British Medical Journal, Vol.338 . Article no. b773. doi:10.1136/bmj.b773 ISSN 0959-8146.
Rose, Helen, Baldwin, Adam, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2009) Biocide susceptibility of the Burkholderia cepacia complex. Journal of Antimicrobial Chemotherapy, Vol.63 (No.3). pp. 502-510. doi:10.1093/jac/dkn540 ISSN 0305-7453.
Ward, Philip N., Holden, Matthew T. G., Leigh, James A., Lennard, Nicola, Bignell, Alexandra, Barron, Andy, Clark, Louise, Quail, Michael A., Woodward, John, Barrell, Bart G., Egan, Sharon A., Field, Terence R., Maskell, Duncan, Kehoe, Michael, Dowson, Christopher G. and Chanter, Neil (2009) Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis. BMC Genomics, Vol.10 . Article No. 54. doi:10.1186/1471-2164-10-54 ISSN 1471-2164.
Vanlaere, Elke, Baldwin, Adam, Gevers, Dirk, Henry, Deborah, De Brandt, Evie, LiPuma, John J., Mahenthiralingam, Eshwar, Speert, David P., Dowson, Christopher G. and Vandamme, Peter (2009) Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp nov and Burkholderia lata sp nov. International Journal of Systematic and Evolutionary Microbiology, Vol.59 (Part 1). pp. 102-111. doi:10.1099/ijs.0.001123-0 ISSN 1466-5026.
Holden, Matthew T. G., Seth-Smith, Helena M. B., Crossman, Lisa C., Sebaihia, Mohammed, Bentley, Stephen D., Cerdeno-Tarraga, Ana M., Thomson, Nicholas R., Bason, Nathalie, Quail, Michael A., Sharp, Sarah et al.
(2009)
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
Journal of Bacteriology, Vol.191
(No.1).
pp. 261-277.
ISSN 0021-9193
doi:10.1128/JB.01230-08
2008
De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200 ISSN 0021-9258.
Marttinen, Pekka, Baldwin, Adam, Hanage, William P., Dowson, Christopher G. and Mahenthiralingam, Eshwar (2008) Bayesian modeling of recombination events in bacterial populations. BMC Bioinformatics, Vol.9 (No.421). doi:10.1186/1471-2105-9-421 ISSN 1471-2105.
Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L. and Dowson, Christopher G. (2008) Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa. Journal of Clinical Microbiology, Vol.46 (No.10). pp. 3491-3493. doi:10.1128/JCM.00357-08 ISSN 0095-1137.
Vanlaere, Elke, LiPuma, John J., Baldwin, Adam, Henry, Deborah, De Brandt, Evie, Mahenthiralingam, Eshwar, Speert, David, Dowson, Christopher G. and Vandamme, Peter (2008) Burkholderia latens sp nov., Burkholderia diffusa sp nov., Burkholderia arboris sp nov., Burkholderia seminalis sp nov and Burkholderia metallica sp nov., novel species within the Burkholderia cepacia complex. International Journal of Systematic and Evolutionary Microbiology, Vol.58 (Part 7). pp. 1580-1590. doi:10.1099/ijs.0.65634-0 ISSN 1466-5026.
Mahenthiralingam, Eshwar, Baldwin, A. (Adam) and Dowson, Christopher G. (2008) Burkholderia cepacia complex bacteria : opportunistic pathogens with important natural biology. Journal of Applied Microbiology, Vol.104 (No.6). pp. 1539-1551. ISSN 1364-5072 doi:10.1111/j.1365-2672.2007.03706.x
Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200 ISSN 0021-9258.
Drevinek, Pavel, Baldwin, Adam, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2008) Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia. BMC Microbiology, Vol.8 (No.44). doi:10.1186/1471-2180-8-44 ISSN 1471-2180.
Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Pope, Chris, Waine, David J., Henry, Deborah A., Speert, David P., Carter, Phil, Vandamme, Peter, LiPuma, John J. and Dowson, Christopher G. (2008) Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. Journal of Clinical Microbiology, Vol.46 (No.1). pp. 290-295. doi:10.1128/JCM.01818-07 ISSN 0095-1137.
2007
Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PL o S Pathogens , Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7366.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.
Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PLoS Pathogens, Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7374.
Dalmastri, Claudia, Baldwin, Adam, Tabacchioni, Silvia, Bevivino, Annamaria, Mahenthiralingam, Eshwar, Chiarini, Luigi and Dowson, Christopher G. (2007) Investigating Burkholderia cepacia complex populations recovered from Italian maize rhizosphere by multilocus sequence typing. Environmental Microbiology, Vol.9 (No.7). pp. 1632-1639. doi:10.1111/j.1462-2920.2007.01273.x ISSN 1462-2912.
Waine, David J., Henry, Deborah A., Baldwin, Adam, Speert, David P., Honeybourne, David, Mahenthiralingam, Eshwar and Dowson, Christopher G. (2007) Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. Journal of Cystic Fibrosis, Vol.6 (No.3). pp. 215-219. doi:10.1016/j.jcf.2006.10.003 ISSN 1569-1993.
Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Vandamme, Peter, Govan, John R., Waine, David J., LiPuma, John J., Chiarini, Luigi, Dalmastri, Claudia, Henry, Deborah A., Speert, David P., Honeybourne, David, Maiden, Martin C. J. and Dowson, Christopher G. (2007) Environmental Burkholderia cepacia complex isolates in human infections. Emerging Infectious Diseases , Vol.13 (No.3). pp. 458-461. doi:10.3201/eid1303.060403 ISSN 1080-6059.
Moore, Lisa J., Gilbey, Andrea M., Dowson, Christopher G., Pridmore, Alison C., Dower, Steven K. and Read, Robert C. (2007) Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics. Journal of Antimicrobial Chemotherapy, Volume 59 (Number 1). pp. 35-42. doi:10.1093/jac/dkl442 ISSN 0305-7453.
Gardner, J. W., Apostolidou, A., Cole, Marina, Dowson, Christopher G., Edmunds, S. and Sehra, G. (2007) Towards a low-cost optical iriosensor system for biomedical immunoassay applications. In: 5th IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, 14-16 Feb 2007. Published in: Proceedings of the Fifth IASTED International Conference on Biomedical Engineering pp. 277-282. ISBN 9780889866485.
2006
Mahenthiralingam, Eshwar, Baldwin, Adam, Drevinek, Pavel, Vanlaere, Elke, Vandamme, Peter, LiPuma, John J. and Dowson, Christopher G. (2006) Multilocus sequence typing breathes life into a microbial metagenome. PLoS One, Vol.1 (No.1). doi:10.1371/journal.pone.0000017 ISSN 1932-6203.
Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., De Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Timothy D. H. (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5. Molecular BioSystems, 2 (10). pp. 484-491. doi:10.1039/b607908c ISSN 1742-206X.
TΓΆtemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan and Bryant, Clare (2006) IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8). pp. 4804-4810. ISSN 0022-1767.
Nelson, E. A., O'Meara, S., Craig, D, Iglesias, C., Golder, S, Dalton, J, Claxton, K, Bell-Syer, S.E.M., Jude, E, Dowson, Christopher G., Gadsby, Roger, O'Hare, J. Paul and Powell, John (2006) A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. Health Technology Assessment, Volume 10 (Number 12). 1-+. ISSN 1366-5278
2005
Smith, Edward M., Green, Laura E., Medley, Graham, Bird, H. E. and Dowson, Christopher G. (2005) Multilocus sequence typing of Staphylococcus aureus isolated from high-somatic-cell-count cows and the environment of an organic dairy farm in the United Kingdom. Journal of Clinical Microbiology, Vol.43 (No.9). pp. 4731-4736. doi:10.1128/JCM.43.9.4731-4736.2005 ISSN 0095-1137.
Smith, Edward M., Green, Laura E., Medley, Graham, Bird, H. E., Fox, L. K., Schukken, Y. H., Kruze, J. V. , Bradley, Andrew J., Zadoks, Ruth N. and Dowson, Christopher G. (2005) Multilocus sequence typing of intercontinental bovine Staphylococcus aureus isolates. Journal of Clinical Microbiology, Vol.43 (No.9). pp. 4737-4743. doi:10.1128/JCM.43.9.4737-4743.2005 ISSN 0095-1137.
2004
Gardner, J. W., Hines, E.L. and Dowson, Christopher G. (2004) Smelling illness. London, UK: Ingenia.
2003
Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L. and Dowson, Christopher G. (2003) Chemical sensor screening of blood samples : robust analysis via data set reduction. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003. Published in: Modellling and Control in Biomedical Systems 2003 (including Biology Systems) pp. 289-294. ISBN 0080441599. ISSN 0962-9505.
This list was generated on Thu Apr 25 00:53:55 2024 BST.