2021

Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J. , Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L. and Corre, Christophe (2021) Molecular basis for control of antibiotic production by a bacterial hormone. Nature, 590 (7846). pp. 463-467. doi:10.1038/s41586-021-03195-x

2020

Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822

2019

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Alkhalaf, Lona M., Barry, Sarah M., Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R., Fülöp, Vilmos and Challis, Gregory L. (2019) Binding of distinct substrate conformations enables hydroxylation of remote sties in thaxtomin D by cytochrome P450 TxtC. Journal of the American Chemical Society, 141 (1). pp. 216-222. doi:10.1021/jacs.8b08864

2017

Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S. and Roper, David I. (2017) Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1). 1939 . doi:10.1038/s41467-017-02118-7

Rea, Dean, Van Elzen, Roos, De Winter, Hans, Van Goethem, Sebastiaan, Landuyt, Bart, Luyten, Walter, Schoofs, Liliane, Van Der Veken, Pieter, Augustyns, Koen, De Meester, Ingrid, Fülöp, Vilmos and Lambeir, Anne-Marie (2017) Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. European Journal of Medicinal Chemistry, 139 . pp. 482-491. doi:10.1016/j.ejmech.2017.08.024

2016

Rahmanpour, Rahman , Rea, Dean, Jamshidi, Shirin, Fülöp, Vilmos and Bugg, Tim (2016) Structure of thermobifida fusca DyP-type peroxidase and activity towards kraft lignin and lignin model compounds. Archives of Biochemistry and Biophysics, 594 . pp. 54-60. doi:10.1016/j.abb.2016.02.019

2015

Rashid, Goran M. M., Taylor, Charles R. (Charles Robert), Liu, Yangqingxu, Zhang, Xiaoyang, Rea, Dean, Fülöp, Vilmos and Bugg, Tim (2015) Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation. ACS chemical biology, 10 (10). pp. 2286-2294. doi:10.1021/acschembio.5b00298

2013

Canning, Peter, Rea, Dean, Morty, Rory E. and Fülöp, Vilmos (2013) Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes. PLoS One, Volume 8 (Number 11). Article number e79349. doi:10.1371/journal.pone.0079349

Marlow, Victoria A., Rea, Dean, Najmudin, Shabir, Wills, Martin and Fülöp, Vilmos (2013) Structure and mechanism of acetolactate decarboxylase. ACS Chemical Biology, 8 (10). pp. 2339-2344. doi:10.1021/cb400429h

Szeltner, Zoltán, Juhász, Tünde, Szamosi, Ilona, Rea, Dean, Fülöp, Vilmos, Módos, Károly, Juliano, Luiz and Polgár, László (2013) The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol.1834 (No.1). pp. 98-111. doi:10.1016/j.bbapap.2012.08.012

2012

Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z

Van der Veken, Pieter, Fülöp, Vilmos, Rea, Dean, Gerard, Melanie, Van Elzen, Roos, Joossens, Jurgen, Cheng, Jonathan D., Baekelandt, Veerle, De Meester, Ingrid, Lambeir, Anne-Marie and Augustyns, Koen (2012) P2-SubstitutedN-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. Journal of Medicinal Chemistry, Vol. 55 (No.22). pp. 9856-9867. doi:10.1021/jm301060g

Van der Veken, Pieter, Fülöp, Vilmos, Rea, Dean, Gerard, Melanie, Van Elzen, Roos, Joossens, Jurgen, Cheng, Jonathan D., Baekelandt, Veerle, De Meester, Ingrid, Lambeir, Anne-Marie and Augustyns, Koen (2012) P2-substitutedN-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase : biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy. Journal of Medicinal Chemistry, Vol.55 (No.22). pp. 9856-9867. doi:10.1021/jm301060g

2011

Rea, Dean and Fülöp, Vilmos (2011) Prolyl oligopeptidase structure and dynamics. CNS & Neurological Disorders - Drug Targets, Vol.10 (No.3). pp. 306-310.

2010

Batson, Sarah, Rea, Dean, Fülöp, Vilmos and Roper, David I. (2010) Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli. Journal of Experimental Psychology: Human Perception and Performance, Vol.66 (No.4). pp. 405-408. doi:10.1107/S1744309110003970

2009

Sergeant, Martin J., Li, J.J., Fox, C., Brookbank, N., Rea, Dean, Bugg, Tim and Thompson, Andrew J. (2009) Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching. Journal of Biological Chemistry, Vol.284 (No.8). pp. 5257-5264. doi:10.1074/jbc.M805453200

2008

Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Tim and Roper, David I. (2008) Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry, Vol.47 (No.38). pp. 9955-9965. doi:10.1021/bi800943g

Gray, R. G., Rea, Dean, Handley, K., Marshall, A. (Andrea), Pritchard, M. G., Perry, P., Earl, Helena M., Poole, Christopher J., Salman, A. and Lee, M. (2008) aTTom (adjuvant Tamoxifen--To offer more?) : randomized trial of 10 versus 5 years of adjuvant tamoxifen among 6,934 women with estrogen receptor-positive (ER+) or ER untested breast cancer--Preliminary results. In: 2008 ASCO Annual Meeting, Chicago, Illinois, 30 May-3 Jun 2008. Published in: Journal of Clinical Oncology, Vol.26 (No.15S (May 20 Supplement)). p. 513. ISSN 0732-183X.

2007

Rea, Dean, Fülöp, Vilmos, Bugg, Tim and Roper, David I. (2007) Structure and mechanism of HpcH : a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.373 (No.4). pp. 866-876. doi:10.1016/j.jmb.2007.06.048

Kevel, Eva, Gyula, Peter, Feher, Balazs, Toth, Reka, Viczian, Andras, Kircher, Stefan, Rea, Dean, Dorjgotov, Dulguun, Schaefer, Eberhard, Millar, A. J. (Andrew J.), Kozma-Bognar, Laszlo and Nagy, Ferenc (2007) Arabidopsis thaliana Circadian clock is regulated by the small GTPase LIP1. Current Biology, Vol.17 (No.17). pp. 1456-1464. doi:10.1016/j.cub.2007.07.018

Bowden, S., Gross, L., Poole, C. J., Hiller, Louise, Agrawal, R. K., McAdam, K. F., Earl, Helena M., Anwar, S. and Rea, Dean (2007) NEAT-A: accelerated sequential epirubicin followed by higher dose 14 day CMF, using pegfilgrastim, is a feasible alternative for delivering dose dense E-CMF chemotherapy in early breast cancer. In: 14th European Cancer Conference (ECCO 14), Barcelona, Spain, SEP 23-27, 2007. Published in: European Journal of Cancer Supplements, Vol.5 (No.4). pp. 194-195. ISSN 1359-6349. doi:10.1016/S1359-6349(07)70797-8

Izumi, Atsushi, Rea, Dean, Adachi, Tomoko, Unzai, Satoru, Park, Sam-Yong, Roper, David I. and Tame, Jeremy R. H. (2007) Structure and mechanism of HpcG, a hydratase in the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.370 (No.5). pp. 899-911. doi:10.1016/j.jmb.2007.05.006

2006

Adachi, Tomoko, Izumi, Atsushi, Rea, Dean, Park, Sam-Yong, Tame, Jeremy R. H. and Roper, David I. (2006) Expression, purification and crystallization of 2-oxo-hept-4-ene-1,7-dioate hydratase (HpcG) from Escherichia coli C. Acta Crystallographica Section F-Structural Biology And Crystallization Communicati, 62 (Part 10). pp. 1010-1012. doi:10.1107/S1744309106035901

Rea, Dean, Hazell, Carole, Andrews, Norma W., Morty, Rory E. and Fülöp, Vilmos (2006) Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei. Acta Crystallographica Section F - Structural Biology and Crystallization Communications, Vol.62 (Part 8). pp. 808-810. doi:10.1107/S1744309106027874