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Number of items: 61.
Journal Article
Abrams, William R., Madsen, Jens, Gaiha, Gaurav D., Palaniyar, Nades, Dong, Tao, Mitchell, Daniel A. and Clark, Howard W. (2013) Surfactant protein D modulates HIV infection of both T-cells and dendritic cells. PLoS One, Volume 8 (Number 3). Article no. e59047. doi:10.1371/journal.pone.0059047 ISSN 1932-6203.
Aburto, N. J., Ziolkovska, A., Hooper, L., Elliott, P., Cappuccio, Francesco and Meerpohl, J. J. (2013) Effect of lower sodium intake on health : systematic review and meta-analyses. BMJ, Volume 346 (Number 346). Article number f1326. doi:10.1136/bmj.f1326 ISSN 0959-535X.
Alokail, Majed S., Sabico, Shaun, Al-Saleh, Yousef, Al-Daghri, Nasser M., Alkharfy, Khalid M., Vanhoutte, Paul M. and McTernan, P. G. (Philip G.) (2013) Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial. Trials, Volume 14 (Number 1). Article number 195. doi:10.1186/1745-6215-14-195 ISSN 1745-6215.
Barber, T. M. and Franks, S. (2013) Adipocyte biology in polycystic ovary syndrome. Molecular and Cellular Endocrinology, Volume 373 (Number 1-2). pp. 68-76. doi:10.1016/j.mce.2012.10.010 ISSN 0303-7207.
Barber, Thomas M. and Franks, S (2013) Genetics of polycystic ovary syndrome. Frontiers of Hormone Research, 40 . pp. 28-39. doi:10.1159/000341682
Barber, Thomas M. and Franks, S. (2013) Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome. Expert Review of Endocrinology and Metabolism, 8 (5). pp. 427-429. doi:10.1586/17446651.2013.827373 ISSN 1744-6651.
Barber, Thomas M., Vojtechova, P. and Franks, S. (2013) The impact of hyperandrogenism in female obesity and cardiometabolic diseases associated with polycystic ovary syndrome. Hormone Molecular Biology and Clinical Investigation, 15 (3). pp. 91-103. doi:10.1515/hmbci-2013-0014 ISSN 1868-1883.
Barneda, David, Frontini, Andrea, Cinti, Saverio and Christian, Mark (2013) Dynamic changes in lipid droplet-associated proteins in the βbrowningβ of white adipose tissues. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1831 (5). pp. 924-933. doi:10.1016/j.bbalip.2013.01.015 ISSN 0167-4889.
Bradnova, Olga, Kyrou, Ioannis, Hainer, Vojtech, Vcelak, Josef, Halkova, Tereza, Sramkova, Petra, Dolezalova, Karin, Fried, Martin, McTernan, P. G. (Philip G.), Kumar, Sudhesh, Hill, Martin, Kunesova, Marie, Bendlova, Bela and Vrbikova, Jana (2013) Laparoscopic greater curvature plication in morbidly obese women with type 2 diabetes : effects on glucose homeostasis, postprandial triglyceridemia and selected gut hormones. Obesity Surgery, Volume 24 (Number 5). pp. 718-726. doi:10.1007/s11695-013-1143-4 ISSN 0960-8923.
Cappuccio, Francesco (2013) Cardiovascular and other effects of salt consumption. Kidney International Supplements, Volume 3 (Number 4). pp. 312-315. doi:10.1038/kisup.2013.65 ISSN 2157-1724.
Chan, W., G. Ward, Douglas, McClean, Andrew, A. Bosch, Jos, Jones, David, Kaur, Okdeed, Drayson, Mark, Whitelegg, Alison, Iqbal, Tariq, McTernan, P. G. (Philip G.), Tselepis, Chris and Borrows, Richard (2013) The role of hepcidin-25 in kidney transplantation. Transplantation Journal, Volume 95 (Number 11). pp. 1390-1395. doi:10.1097/TP.0b013e31828d8489 ISSN 0041-1337.
Chan, Winnie M. F., Bosch, Jos A., Jones, David, Kaur, Okdeep, Inston, N., Moore, S., McLean, A., McTernan, P. G., Harper, L., Phillips, Anna C. and Borrows, Richard (2013) Predictors and consequences of fatigue in prevalent kidney transplant recipients. Transplantation, 96 (11). pp. 987-994. doi:10.1097/TP.0b013e3182a2e88b ISSN 0041-1337.
Conner, Alex C., Bill, Roslyn M. and Conner, Matthew T. (2013) An emerging consensus on aquaporin translocation as a regulatory mechanism. Molecular Membrane Biology, Volume 30 (Number 1). pp. 101-112. doi:10.3109/09687688.2012.743194 ISSN 0968-7688.
Engineer, Neelam, Darwin, Lucy, Nishigandh, Deole, Kandala, Ngianga-Bakwin, Smith, Steve C. and Grammatopoulos, Dimitris (2013) Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum. Journal of Psychiatric Research, Volume 47 (Number 9). pp. 1166-1173. doi:10.1016/j.jpsychires.2013.05.003 ISSN 0022-3956.
Girija, Umakhanth Venkatraman, Gingras, Alexandre R., Marshall, J. E., Panchal, R., Sheikh, M. A., Gal, P., Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E. and Wallis, Russell (2013) Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proceedings of the National Academy of Sciences of the United States of America, Volume 110 (Number 34). pp. 13916-13920. doi:10.1073/pnas.1311113110 ISSN 0027-8424.
Goodyear, Stephen J., Yow, Heng, Saedon, Mahmud H., Shakespeare, Joanna, Hill, Christopher E., Watson, Duncan, Dr., Marshall, Colette, Dr., Mahmood, Asif, Higman, Daniel and Imray, C. (Chris) (2013) Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery : a cohort study. Perioperative Medicine, Volume 2 (Number 1). Article number 10. doi:10.1186/2047-0525-2-10 ISSN 2047-0525.
Handley, Louise, Adams, Dawn, Simkiss, Douglas E. and Oliver, Chris (2013) Self-injurious, aggressive and destructive behaviour in young children with a moderate to profound intellectual disability. Paediatrics and Child Health, Volume 23 (Number 7). pp. 322-324. doi:10.1016/j.paed.2013.04.004 ISSN 1751-7222.
Harrison, Elizabeth, Liu, Kuo-Kang, Petchey, Michael, Nwokolo, Chuka U., Loft, Duncan and Arasaradnam, Ramesh P. (2013) Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway. Postgraduate Medical Journal, Volume 89 (Number 1047). pp. 4-7. doi:10.1136/postgradmedj-2011-130188 ISSN 0032-5473.
Harte, A. L., Tripathi, Gyanendra, Piya, Milan K., Barber, T. M., Clapham, John C., Al-Daghri, Nasser, Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh and McTernan, P. G. (2013) NFΞΊB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFΞ±. Obesity research, 21 (11). pp. 2322-23300. doi:10.1002/oby.20336 ISSN 1071-7323.
Harte, A. L. (Alison L.) and McTernan, P. G. (Philip G.) (2013) Response to comment on : Harte et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in Type 2 diabetic subjects. Diabetes Care 2012;35:375-382. Diabetes Care, Volume 36 (Number 3). e43-e43. doi:10.2337/dc12-2301 ISSN 0149-5992.
Hattersley, John G., Chappell, M. J. (Michael J.), Zehnder, Daniel, Higgins, Rob and Evans, Neil D. (2013) Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 126-133. doi:10.1016/j.cmpb.2011.12.013 ISSN 0169-2607.
Hopkins, Seth C., Campbell, Una C., Heffernan, Michele L. R., Spear, Kerry L., Jeggo, Ross D., Spanswick, David C., Varney, Mark A. and Large, Thomas H. (2013) Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo. Pharmacology Research & Perspectives, Volume 1 (Number 1). doi:10.1002/prp2.7 ISSN 2052-1707.
Hopkins, Seth C., Zhao, Fei-Yue, Bowen, C. A, Fang, Xin, Dr., Weiss, Howard, Heffernan, Michele L. R., Spear, Kerry L., Spanswick, David, Varney, Mark A. and Large, Thomas H. (2013) Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain. Journal of Pharmacology and Experimental Therapeutics, Volume 345 (Number 3). pp. 502-511. doi:10.1124/jpet.113.204016 ISSN 1521-0103.
Huang, Jin, Zhang, Qiang, Li, GuangβZhao, Haddleton, David M., Wallis, Russell, Mitchell, Daniel A., Heise, Andreas and Becer, C. Remzi (2013) Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking. Macromolecular Rapid Communications, 34 (19). pp. 1542-1546. doi:10.1002/marc.201300439 ISSN 1022-1336.
Imray, C. (Chris), Buxton, Pauline, Saedon, Mahmud H., Hutchinson, Charles E. and Singer, Donald R. J. (2013) Regarding βIntraoperative use of dextran is associated with cardiac complications after carotid endarterectomyβ. Journal of Vascular Surgery, Volume 58 (Number 4). p. 1167. doi:10.1016/j.jvs.2013.05.102 ISSN 0741-5214.
Imray, C. (Chris), Kelly, Andrew and Wilson, Mark (2013) Has anyone seen my executive function recently? Wilderness & Environmental Medicine, Volume 24 (Number 2). pp. 174-175. doi:10.1016/j.wem.2012.10.003 ISSN 1080-6032.
Iqbal, H. (Hasan), Ting, Stephen M. S. , Hamborg, Thomas, Imray, C. (Chris), Hewins, Susan, Banerjee, Prithwish, Bland, R. (Rosemary), Higgins, Rob and Zehnder, Daniel (2013) Reduced functional measure of cardiovascular reserve predicts admission to critical care unit following kidney transplantation. PLoS One, Volume 8 (Number 5). Article number e64335. doi:10.1371/journal.pone.0064335 ISSN 1932-6203.
Krishnan, Nithya S., Zehnder, Daniel, Daga, Sunil, Lowe, David Philip, Lam, F. T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Hamer, Rizwan, Briggs, David, Dr., Raymond, Neil T. and Higgins, Rob (2013) Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation. PLoS One, Volume 8 (Number 7). Article number e68663. doi:10.1371/journal.pone.0068663 ISSN 1932-6203.
Kshirsagar, M., Carbonell, J. and Klein-Seetharaman, Judith (2013) Multitask learning for host-pathogen protein interactions. Bioinformatics, Volume 29 (Number 13). i217-i226. doi:10.1093/bioinformatics/btt245 ISSN 1367-4803.
Lee, T. -W. A., Kwon, H., Zong, H., Yamada, Eijiro, Vatish, Manu, Pessin, J. E. and Bastie, Claire C. (2013) Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes, Volume 62 (Number 5). pp. 1537-1546. doi:10.2337/db12-0920 ISSN 0012-1797.
Lowe, David Philip, Higgins, Rob, Zehnder, Daniel and Briggs, D. C. (2013) Significant IgG subclass heterogeneity in HLA-specific antibodies : implications for pathogenicity, prognosis, and the rejection response. Human Immunology, Volume 74 (Number 5). pp. 666-672. doi:10.1016/j.humimm.2013.01.008 ISSN 0198-8859.
Makura, Caroline BT, Nirantharakumar, Krishnarajah, Girling, Alan J, Saravanan, Ponnusamy and Narendran, Parth (2013) Effects of physical activity on the development and progression of microvascular complications in type 1 diabetes : retrospective analysis of the DCCT study. BMC Endocrine Disorders, Volume 13 (Number 1). Article number 37. doi:10.1186/1472-6823-13-37 ISSN 1472-6823.
Markovic, Danijela, Bari, Muhammad F., Lu, B., Vatish, Manu and Grammatopoulos, Dimitris (2013) Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. Journal of Clinical Endocrinology & Metabolism, Volume 98 (Number 7). pp. 2864-2875. doi:10.1210/jc.2013-1094 ISSN 0021-972X.
Markovic, Danijela, Bari, Muhammad F., Lu, Buyu, Vatish, Manu and Grammatopoulos, Dimitris (2013) Corticotropin-releasing hormone intereacts with interleukin-1 beta to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. Journal of Clinical Endocrinology & Metabolism , 98 (7). pp. 2864-2875. ISSN 0021-972x.
Mattu, Harman and Randeva, Harpal S. (2013) Role of adipokines in cardiovascular disease. Journal of Endocrinology, Vol.216 (No.1). T17-T36. doi:10.1530/JOE-12-0232 ISSN 0022-0795.
Murch, Simon, Jenkins, H. Donald Brooke, Auth, M. , Bremner, R. , Butt, A. , France, S. , Furman, M. , Gillett, P. , Kiparissi, F. , Lawson, M. , McLain, B. , Morris, M.-A. , Sleet, S. and Thorpe, M. (2013) Joint BSPGHAN and coeliac UK guidelines for the diagnosis and management of coeliac disease in children. Archives of Disease in Childhood, Volume 98 (Number 10). pp. 806-811. doi:10.1136/archdischild-2013-303996 ISSN 0003-9888.
O'Hare, Eugene, Scopes, David I.C., Kim, Eun-Mee, Palmer, Philip, Jones, Martyn, Whyment, Andrew D., Spanswick, David C., Amijee, Hozefa, Nerou, Edmund, McMahon, Bridgeen, Treherne, J. Mark and Jeggo, Ross (2013) Orally bioavailable small molecule drug protects memory in Alzheimer's disease models. Neurobiology of Aging, 34 (4). pp. 1116-1125. doi:10.1016/j.neurobiolaging.2012.10.016 ISSN 0197-4580.
Panicker, Vijay, Saravanan, Ponnusamy, Vaidya, Bijay, Evans, Jonathan, Hattersley, Andrew T., Frayling, Timothy M. and Dayan, Colin M. (2013) Common variation in the DIO2Gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. The Journal of Clinical Endocrinology & Metabolism, 94 (5). pp. 1623-1629. doi:10.1210/jc.2008-1301 ISSN 0021-972X.
Pivovarova, Olga, Bernigau, Wolfgang, Bobbert, Thomas, Isken, Frank, MΓΆhlig, Matthias, Spranger, Joachim, Weickert, Martin O., Osterhoff, Martin, Pfeiffer, Andreas F. H. and Rudovich, Natalia N. (2013) Hepatic insulin clearance is closely related to metabolic syndrome components. Diabetes Care, Volume 36 (Number 11). pp. 3779-3785. doi:10.2337/dc12-1203 ISSN 0149-5992.
Piya, Milan K., Harte, Alison L. and McTernan, P. G. (2013) Metabolic endotoxaemia. Current Opinion in Lipidology, Volume 24 (Number 1). pp. 78-85. doi:10.1097/MOL.0b013e32835b4431 ISSN 0957-9672.
Piya, Milan K., McTernan, P. G. and Kumar, Sudhesh (2013) Adipokine inflammation and insulin resistance : the role of glucose, lipids and endotoxin. Journal of Endocrinology, Vol.216 (No.1). T1-T15. doi:10.1530/JOE-12-0498 ISSN 0022-0795.
Ramanjaneya, Manjunath, Addison, Melisande and Randeva, Harpal S. (2013) Possible role of NUCB2/nesfatin-1 in adipogenesis. Current pharmaceutical design, 19 (39). pp. 6976-80. doi:10.2174/138161281939131127142959 ISSN 1873-4286.
Ramanjaneya, Manjunath, Karteris, Emmanouil, Chen, Jing, Rucinski, R., Ziolkowska, A., Ahmed, Naila, Kagerer, S., Johren, O., Lehnert, Hendrik, Malendowicz, L. K. and Randeva, Harpal S. (2013) QRFP induces aldosterone production via PKC and T-type calcium channel-mediated pathways in human adrenocortical cells : evidence for a novel role of GPR 103. American Journal of Physiology: Endocrinology and Metabolism, 305 (9). E1049-E1058. ISSN 0193-1849.
Robinson, Louise E., Holt, Tim A., Rees, Karen, Randeva, Harpal S. and O'Hare, J. Paul (2013) Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis. BMJ Open, Vol.3 (No.1). Article no. e001986. doi:10.1136/bmjopen-2012-001986 ISSN 2044-6055.
Saboor Aftab, S. A., Kumar, Sudhesh and Barber, T. M. (2013) The role of obesity and type 2 diabetes mellitus in the development of male obesity-associated secondary hypogonadism. Clinical Endocrinology, Volume 78 (Number 3). pp. 330-337. doi:10.1111/cen.12092 ISSN 0300-0664.
Saboor Aftab, S. A., Reddy, Narendra Lakshmana, Owen, N. L., Pollitt, R., Harte, A. L., McTernan, P. G., Tripathi, Gyanendra and Barber, T. M. (2013) Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene manifesting clinically as osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports . p. 13. EDM130002. doi:10.1530/EDM-13-0002
Saratzis, Athanasios N., Goodyear, Steven, Sur, Hariom, Saedon, Mahmud H., Imray, C. (Chris) and Mahmood, Asif (2013) Acute kidney injury after endovascular repair of abdominal aortic aneurysm. Journal of Endovascular Therapy, Volume 20 (Number 3). pp. 315-330. doi:10.1583/12-4104MR2.1 ISSN 1526-6028.
Schlattner, U., Tokarska-Schlattner, M., Ramirez, S., Tyurina, Y. Y., Amoscato, A. A., Mohammadyani, D., Huang, Z., Jiang, J., Yanamala, N., Seffouh, A., Boissan, M., Epand, R. F., Epand, R. M., Klein-Seetharaman, Judith, Lacombe, M.-L. and Kagan, V. E. (2013) Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer : a cardiolipin-dependent switch. Journal of Biological Chemistry, 288 (1). pp. 111-121. doi:10.1074/jbc.M112.408633 ISSN 0021-9258.
Schnell, Oliver, Cappuccio, Francesco, Genovese, Stefano, Standl, E. (Eberhard), Valensi, Paul and Ceriello, Antonio (2013) Type 1 diabetes and cardiovascular disease. Cardiovascular Diabetology, Volume 12 (Number 1). p. 156. doi:10.1186/1475-2840-12-156 ISSN 1475-2840.
Simkiss, Douglas E. (2013) The United Nations Convention on the Rights of Persons with Disabilities. Paediatrics and Child Health, Volume 23 (Number 10). pp. 449-452. doi:10.1016/j.paed.2013.04.012 ISSN 1751-7222.
Simkiss, Douglas E., Snooks, Helen, Stallard, Nigel, Kimani, Peter K., Sewell, Bernadette, Fitzsimmons, Deborah, Anthony, Rebecca, Winstanley, Sarah, Wilson, Lynsey, Phillips, Ceri and Stewart-Brown, Sarah L. (2013) Effectiveness and cost-effectiveness of a universal parenting skills programme in deprived communities : multicentre randomised controlled trial. BMJ Open, Volume 3 (Number 8). Article number 002851. doi:10.1136/bmjopen-2013-002851 ISSN 2044-6055.
Sivakumar, Kavitha, Tan, Bee K., Bari, Muhammad F., Vatish, Manu and Randeva, Harpal S. (2013) Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes. PLoS One, Volume 8 (Number 6). e65254. doi:10.1371/journal.pone.0065254 ISSN 1932-6203.
Sivaraman, S., Barber, Thomas M., O'Hare, P. and Randeva, H. S. (2013) Glucagon like peptide-1 based therapies : effects beyond blood glucose control. British Journal of Diabetes and Vascular Disease, 13 (5-6). pp. 229-237. doi:10.1177/1474651413504119 ISSN 1474-6514.
Tan, Bee K., Chen, Jing, Adya, Raghu, Ramanjaneya, Manjunath, Patel, Vanlata H. and Randeva, Harpal S. (2013) Metformin increases the novel adipokine adipolin/CTRP12 : role of the AMPK pathway. Journal of Endocrinology, Volume 219 (Number 2). pp. 101-108. doi:10.1530/JOE-13-0277 ISSN 0022-0795.
Tan, Bee K., Chen, Jing, Hu, Jiamiao, Amar, Omar, Mattu, Harman, Adya, Raghu, Patel, Vanlata H., Ramanjaneya, Manjunath, Lehnert, Hendrik and Randeva, Harpal S. (2013) Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 98 (12). E1891-E1900. doi:10.1210/jc.2013-2227 ISSN 0021-972X.
Tarabra, Elena, Yang, Yingjuan, Yang, Gong-She, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Kurland, Irwin J., Pessin, Jeffrey E. and Bastie, Claire C. (2013) Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice. PLoS One, Volume 8 (Number 11). Article number e81866. doi:10.1371/journal.pone.0081866 ISSN 1932-6203.
Urena-Torres, P., Bridges, I., Christiano, C., Cournoyer, S. H., Cooper, K., Farouk, M., Kopyt, N. P., Rodriguez, M., Zehnder, Daniel and Covic, A. (2013) Efficacy of cinacalcet with low-dose vitamin D in incident haemodialysis subjects with secondary hyperparathyroidism. Nephrology Dialysis Transplantation, Volume 28 (Number 5). pp. 1241-1254. doi:10.1093/ndt/gfs568 ISSN 0931-0509.
(2013) The cerebral venous system and anatomical predisposition to high altitude headache. Annals of Neurology, Volume 73 (Number 3). pp. 381-389. doi:10.1002/ana.23796 ISSN 0364-5134.
Zammit, Victor A. (2013) Hepatic triacylglycerol synthesis and secretion : DGAT2 as the link between glycaemia and triglyceridaemia. Biochemical Journal, Volume 451 (Number 1). pp. 1-12. doi:10.1042/BJ20121689 ISSN 0264-6021.
Book Item
Barber, Thomas M. and Franks, S. (2013) The genetics of polycystic ovary syndrome. In: Macut, D. and Pfeifer, M. and Yildiz, B. O. and Diamanti-Kandarakis, E., (eds.) Polycystic Ovary Syndrome: Novel Insights into Causes and Therapy. Karger. ISBN 9783318022384
Journal Item
Ji, Chen, Dary, Omar, Campbell, Norm R. C. and Cappuccio, Francesco (2013) Spot and overnight urine are inappropriate to assess population sodium intake. Revista panamericana de salud pΓΊblica = Pan American journal of public health, Volume 34 (Number 4). p. 283.