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Abnormal P300 in people with high risk of developing psychosis
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Bramon, Elvira, Shaikh, Madiha, Broome, Matthew R., Lappin, Julia, Bergé, Daniel, Day, Fern, Woolley, J. B. (James B.), Tabraham, Paul, Madre, Mercè, Johns, Louise C., Valmaggia, Lucia, Pérez, Victor, Sham, Pak, Murray, Robin, MD, M Phil, MRCP, MRC Psych and McGuire, Philip (2008) Abnormal P300 in people with high risk of developing psychosis. Neuroimage, Vol.41 (No.2). pp. 553-560. doi:10.1016/j.neuroimage.2007.12.038 ISSN 1053-8119.
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Official URL: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038...
Abstract
Background
Individuals with an “at-risk mental state” (or “prodromal” symptoms) have a 20–40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.
Method
35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.
Results
The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.
Conclusion
Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry B Philosophy. Psychology. Religion > BF Psychology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Psychoses, Neuropsychology | ||||
Journal or Publication Title: | Neuroimage | ||||
Publisher: | Elsevier | ||||
ISSN: | 1053-8119 | ||||
Official Date: | 4 January 2008 | ||||
Dates: |
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Volume: | Vol.41 | ||||
Number: | No.2 | ||||
Page Range: | pp. 553-560 | ||||
DOI: | 10.1016/j.neuroimage.2007.12.038 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Description: | Version accepted by publisher (post-print, after peer review, before copy-editing) |
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