The Library
Molecular targeted therapies in adrenal, pituitary and parathyroid malignancies
Tools
Angelousi, Anna, Dimitriadis, Georgios K., Zografos, Georgios, Nölting, Svenja, Kaltsas, Gregory and Grossman, Ashley (2017) Molecular targeted therapies in adrenal, pituitary and parathyroid malignancies. Endocrine-Related Cancer, 24 (6). R239-R259. doi:10.1530/ERC-16-0542 ISSN 1351-0088.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1530/ERC-16-0542
Abstract
Tumourigenesis is a relatively common event in endocrine tissues. Currently, specific guidelines have been developed for common malignant endocrine tumours, which also incorporate advances in molecular targeted therapies (MTT), as in thyroid cancer and in gastrointestinal neuroendocrine malignancies. However, there is little information regarding the role and efficacy of MTT in the relatively rare malignant endocrine tumours mainly involving the adrenal medulla, adrenal cortex, pituitary, and parathyroid glands. Due to the rarity of these tumours and the lack of prospective studies, current guidelines are mostly based on retrospective data derived from surgical, locoregional and ablative therapies, and studies with systemic chemotherapy. In addition, in many of these malignancies the prognosis remains poor with individual patients responding differently to currently available treatments, necessitating the development of new personalised therapeutic strategies. Recently, major advances in the molecular understanding of endocrine tumours based on genomic, epigenomic, and transcriptome analysis have emerged, resulting in new insights into their pathogenesis and molecular pathology. This in turn has led to the use of novel MTTs in increasing numbers of patients. In this review, we aim to present currently existing and evolving data using MTT in the treatment of adrenal, pituitary and malignant parathyroid tumours, and explore the current utility and effectiveness of such therapies and their future evolution.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Journal or Publication Title: | Endocrine-Related Cancer | ||||||||
Publisher: | BioScientifica | ||||||||
ISSN: | 1351-0088 | ||||||||
Official Date: | June 2017 | ||||||||
Dates: |
|
||||||||
Volume: | 24 | ||||||||
Number: | 6 | ||||||||
Page Range: | R239-R259 | ||||||||
DOI: | 10.1530/ERC-16-0542 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |