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Imino transfer hydrogenation reductions
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Wills, Martin (2016) Imino transfer hydrogenation reductions. Topics in Current Chemistry, 374 (2). 14. doi:10.1007/s41061-016-0013-7 ISSN 0340-1022.
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Official URL: http://dx.doi.org/10.1007/s41061-016-0013-7
Abstract
This review contains a summary of recent developments in the transfer hydrogenation of C=N bonds, with a particularly focus on reports from within the last 10 years and asymmetric transformations. However, earlier work in the area is also discussed in order to provide context for the more recent results described. I focus strongly on the Ru/TsDPEN class of asymmetric transfer hydrogenation reactions originally reported by Noyori et al., together with examples of their applications, particularly to medically valuable target molecules. The recent developments in the area of highly active imine-reduction catalysts, notably those based on iridium, are also described in some detail. I discuss diastereoselective reduction methods as a route to the synthesis of chiral amines using transfer hydrogenation. The recent development of a methodology for positioning reduction complexes within chiral proteins, permitting the generation of asymmetric reduction products through a directed modification of the protein environment in a controlled manner, is also discussed.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Hydrogenation, Imino compounds, Nitrogen, Carbon, Amines | ||||||||
Journal or Publication Title: | Topics in Current Chemistry | ||||||||
Publisher: | Springer | ||||||||
ISSN: | 0340-1022 | ||||||||
Official Date: | April 2016 | ||||||||
Dates: |
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Volume: | 374 | ||||||||
Number: | 2 | ||||||||
Article Number: | 14 | ||||||||
DOI: | 10.1007/s41061-016-0013-7 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 28 March 2018 | ||||||||
Date of first compliant Open Access: | 28 March 2018 |
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