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Facially amphipathic glycopolymers inhibit ice recrystallization
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Graham, Ben, Fayter, Alice, Houston, Judith E., Evans, Rachel C. and Gibson, Matthew I. (2018) Facially amphipathic glycopolymers inhibit ice recrystallization. Journal of the American Chemical Society, 140 (17). pp. 5682-5685. doi:10.1021/jacs.8b02066 ISSN 1520-5126.
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Official URL: http://dx.doi.org/10.1021/jacs.8b02066
Abstract
Antifreeze glycoproteins from polar fish are the most potent ice recrystallization (growth) inhibitors known, and synthetic mimics are required for low tem- perature applications such as cell cryopreservation. Here we introduce facially amphipathic glycopolymers which mimic the 3-dimensional structure of AFGPs. Glycopol- ymers featuring segregated hydrophilic and hydrophobic faces were prepared by ring-opening metathesis polymer- ization and their rigid conformation was confirmed by small-angle neutron scattering. Ice recrystallization inhi- bition (IRI) activity was reduced when a hydrophilic oxo- ether was installed on the glycan-opposing face, but sig nificant activity was restored by incorporating a hydro- phobic dimethylfulvene residue. This biomimetic strategy demonstrates that segregated domains of distinct hydrophilicity/hydrophobicity are a crucial motif to introduce IRI activity, and increases our under- standing of the complex ice crystal inhibition processes.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Glycoproteins -- Synthesis, Antifreeze proteins, Ice crystals -- Growth, Amphiphiles -- Synthesis, Ring-opening polymerization | ||||||||
Journal or Publication Title: | Journal of the American Chemical Society | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 1520-5126 | ||||||||
Official Date: | 2 May 2018 | ||||||||
Dates: |
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Volume: | 140 | ||||||||
Number: | 17 | ||||||||
Page Range: | pp. 5682-5685 | ||||||||
DOI: | 10.1021/jacs.8b02066 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 17 April 2018 | ||||||||
Date of first compliant Open Access: | 21 January 2019 | ||||||||
RIOXX Funder/Project Grant: |
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