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COSCA (Core Outcome Set for Cardiac Arrest) in adults : an advisory statement from the International Liaison Committee on Resuscitation
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(2018) COSCA (Core Outcome Set for Cardiac Arrest) in adults : an advisory statement from the International Liaison Committee on Resuscitation. Circulation, 137 (22). e783-e801. doi:10.1161/CIR.0000000000000562 ISSN 0009-7322.
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WRAP-COSCA-Core-Outcome-Set-Cardiac-Arrest-adults-Haywood-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1081Kb) | Preview |
Official URL: https://doi.org/10.1161/CIR.0000000000000562
Abstract
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The Core Outcome Set for Cardiac Arrest (COSCA) initiative, a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomized clinical effectiveness trials (sometimes referred to as pragmatic trials, phase III/IV trials) rather than for pilot or efficacy studies.
A systematic review of the literature combined with qualitative interviews among cardiac arrest survivors was used to generate a list of potential outcome domains. This list was prioritized through a Delphi process, which involved clinicians, patients, and their relatives/partners. An international advisory panel narrowed these down to 3 core domains by debate leading to consensus. The writing group refined recommendations for when these outcomes should be measured and further characterized relevant measurement tools.
Consensus emerged that a core outcome set for reporting on effectiveness studies of cardiac arrest (COSCA) in adults should include survival, neurologic function, and health-related quality of life. This should be reported as survival status and modified Rankin Scale score at hospital discharge and / or 30 days. Health-related quality of life should be measured by using 1 or more tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey, EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac arrest, if resources allow.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Cardiac arrest -- Treatment., Heart -- Handbooks, manuals, etc. -- Treatment., Cardiology -- Handbooks, manuals, etc., Outcome assessment (Medical care), Clinical trials -- Evaluation. | ||||||
Journal or Publication Title: | Circulation | ||||||
Publisher: | American Heart Association | ||||||
ISSN: | 0009-7322 | ||||||
Official Date: | 26 April 2018 | ||||||
Dates: |
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Volume: | 137 | ||||||
Number: | 22 | ||||||
Page Range: | e783-e801 | ||||||
DOI: | 10.1161/CIR.0000000000000562 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 1 May 2018 | ||||||
Date of first compliant Open Access: | 26 October 2018 | ||||||
Version or Related Resource: | http://wrap.warwick.ac.uk/98596 | ||||||
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