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Investigating the assumptions of the self-controlled case series method
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Whitaker, Heather J., Ghebremichael Weldeselassie, Yonas, Douglas, Ian J., Smeeth, Liam and Farrington, C. Paddy (2018) Investigating the assumptions of the self-controlled case series method. Statistics in Medicine, 37 (4). pp. 643-658. doi:10.1002/sim.7536 ISSN 0277-6715.
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Official URL: http://dx.doi.org/10.1002/sim.7536
Abstract
We describe some simple techniques for investigating 2 key assumptions of the self‐controlled case series (SCCS) method, namely, that events do not influence subsequent exposures and that events do not influence the length of observation periods. For each assumption, we propose some simple tests based on the standard SCCS model, along with associated graphical displays. The methods also enable the user to investigate the robustness of the results obtained using the standard SCCS model to failure of assumptions. The proposed methods are investigated by simulations and applied to data on measles, mumps and rubella vaccine, and antipsychotics.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Medical statistics | ||||||||
Journal or Publication Title: | Statistics in Medicine | ||||||||
Publisher: | John Wiley & Sons Ltd. | ||||||||
ISSN: | 0277-6715 | ||||||||
Official Date: | 20 February 2018 | ||||||||
Dates: |
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Volume: | 37 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 643-658 | ||||||||
DOI: | 10.1002/sim.7536 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 16 July 2018 | ||||||||
Date of first compliant Open Access: | 2 November 2018 | ||||||||
RIOXX Funder/Project Grant: |
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