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Etoposide protein binding in cancer patients
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Liu, B., Earl, H. M., Poole, C. J., Dunn, Janet A. and Kerr, D. J. (1995) Etoposide protein binding in cancer patients. Cancer Chemotherapy and Pharmacology, 36 (6). pp. 506-512. doi:10.1007/BF00685801 ISSN 0344-5704.
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Official URL: https://doi.org/10.1007/BF00685801
Abstract
The protein binding of etoposide was studied in vivo in 36 cancer patients receiving etoposide therapy. Free etoposide was separated from plasma using an ultrafiltration method and the etoposide concentrations (free and total) were measured by high-performance liquid chromatography (HPLC). Considerable interpatient variation in the protein binding of etoposide was observed. The protein binding of etoposide varied from 80% to 97% (mean, 93%). Univariate analysis showed a significant inverse correlation between the free fraction of etoposide and serum albumin (r=−0.74), daily dose (r=−0.37) and age (r=−0.34). Multivariate analysis demonstrated that serum albumin and age were independent predictors of the etoposide free fraction. Serum bilirubin showed no correlation with etoposide protein binding. There is wide variation in etoposide protein binding in cancer patients, which is mostly dependent on serum albumin concentration.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Cancer Chemotherapy and Pharmacology | ||||||
Publisher: | Springer | ||||||
ISSN: | 0344-5704 | ||||||
Official Date: | November 1995 | ||||||
Dates: |
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Volume: | 36 | ||||||
Number: | 6 | ||||||
Page Range: | pp. 506-512 | ||||||
DOI: | 10.1007/BF00685801 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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