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Geographic variation in human papillomavirus-related oropharyngeal cancer : data from 4 multinational randomized trials
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Mehanna, H., Franklin, N., Compton, N., Robinson, M., Powell, N., Biswas-Baldwin, N., Paleri, V., Hartley, A., Fresco, L., Al-Booz, H., Junor, E., El-Hariry, I., Roberts, S., Harrington, K., Ang, K. K., Dunn, Janet A. and Woodman, C. (2016) Geographic variation in human papillomavirus-related oropharyngeal cancer : data from 4 multinational randomized trials. Head and Neck, 38 . E1863-E1869. doi:10.1002/hed.24336
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Official URL: https://doi.org/10.1002/hed.24336
Abstract
Background There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays. Methods We tested formalin-fixed paraffin-embedded diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by polymerase chain reaction [PCR] and in situ hybridization [ISH]) using validated protocols on samples from 801 patients with head and neck cancer recruited prospectively between 2006 and 2011 in 4 randomized controlled trials (RCTs). Results Twenty-one percent of patients (170 of 801) showed both HPV-DNA and p16-positivity, detected almost exclusively in oropharyngeal cancer (55%; 15 of 302); and only 1% of the patients (5 of 499) with nonoropharyngeal cancer were HPV positive. HPV-positive oropharyngeal cancer differed between Western and Eastern Europe (37%, 155 of 422 vs 6%, 8 of 144; p <.0001) and between Western Europe and Asia (37% vs 2%; 4 of 217; p <.0001). Other independent determinants of HPV positivity were tumor site and smoking. Conclusion This is the first study to establish geographic variability as an independent risk factor in HPV-positive oropharyngeal cancer prevalence, with higher prevalence in Western Europe. © 2016 Wiley Periodicals, Inc..
Item Type: | Journal Item | ||||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Head and Neck | ||||||
Publisher: | John Wiley and Sons Inc. | ||||||
ISSN: | 1043-3074 | ||||||
Official Date: | 8 January 2016 | ||||||
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Volume: | 38 | ||||||
Page Range: | E1863-E1869 | ||||||
DOI: | 10.1002/hed.24336 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Open Access Version: |
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