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Topological complexity, contact order, and protein folding rates
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Faisca, P. F. N. and Ball, Robin (2002) Topological complexity, contact order, and protein folding rates. Journal of Chemical Physics, Vol.117 (No.18). pp. 8587-8591. doi:10.1063/1.1511509 ISSN 0021-9606.
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Official URL: http://dx.doi.org/10.1063/1.1511509
Abstract
Monte Carlo simulations of protein folding show the emergence of a strong correlation between the relative contact order parameter, CO, and the folding time, t, of two-state folding proteins for longer chains with number of amino acids Ngreater than or equal to54, and higher contact order, CO>0.17. The correlation is particularly strong for N=80 corresponding to slow and more complex folding kinetics. These results are qualitatively compatible with experimental data where a general trend towards increasing t with CO is indeed observed in a set of proteins with chain length ranging from 41 to 154 amino acids.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QC Physics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Library of Congress Subject Headings (LCSH): | Protein folding, Monte Carlo method, Topology, Molecular biology, Thermodynamics, Biophysics | ||||
Journal or Publication Title: | Journal of Chemical Physics | ||||
Publisher: | American Institute of Physics | ||||
ISSN: | 0021-9606 | ||||
Official Date: | 8 November 2002 | ||||
Dates: |
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Volume: | Vol.117 | ||||
Number: | No.18 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 8587-8591 | ||||
DOI: | 10.1063/1.1511509 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 5 December 2015 | ||||
Date of first compliant Open Access: | 5 December 2015 |
Data sourced from Thomson Reuters' Web of Knowledge
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