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TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care : a randomised controlled trial with patient preference study [ISRCTN79353052]
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Cross, Pamela L., Ashby, Deborah, Harding, Geoff, Hennessy, Enid M., Letley, Louise, Parsons, Suzanne, Spencer, Anne E. and Underwood, Martin (2005) TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care : a randomised controlled trial with patient preference study [ISRCTN79353052]. BMC Musculoskeletal Disorders, 6 (1). 55. doi:10.1186/1471-2474-6-55 ISSN 1471-2474.
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Official URL: http://dx.doi.org/10.1186/1471-2474-6-55
Abstract
Background: Many older people have chronic knee pain. Both topical and oral non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this. Oral NSAIDS are effective, at least in the short term, but can have severe adverse effects. Topical NSAIDs also appear to be effective, at least in the short term. One might expect topical NSAIDs both to be less effective and to have fewer adverse effects than oral NSAIDs. If topical NSAIDs have fewer adverse effects this may outweigh both the reduction in effectiveness and the higher cost of topical compared to oral treatment. Patient preferences may influence the comparative effectiveness of drugs delivered via different routes. Methods: TOIB is a randomised trial comparing topical and oral ibuprofen, with a parallel patient preference study. We are recruiting people aged 50 or over with chronic knee pain, from 27 MRC General Practice Research Framework practices across the UK. We are seeking to recruit 283 participants to the RCT and 379 to the PPS. Participants will be followed up for up to two years (with the majority reaching one year). Outcomes will be assessed by postal questionnaire, nurse examination, laboratory tests and medical record searches at one and two years or the end of the study. Discussion: This study will provide new evidence on the overall costs and benefits of treating chronic knee pain with either oral or topical ibuprofen. The use of a patient preference design is unusual, but will allow us to explore how preference influences response to a medication. In addition, it will provide more information on adverse events. This study will provide evidence to inform primary care practitioners, and possibly influence practice. © 2005 Cross et al; licensee BioMed Central Ltd.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | BMC Musculoskeletal Disorders | ||||
Publisher: | Biomed central | ||||
ISSN: | 1471-2474 | ||||
Official Date: | 7 November 2005 | ||||
Dates: |
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Volume: | 6 | ||||
Number: | 1 | ||||
Article Number: | 55 | ||||
DOI: | 10.1186/1471-2474-6-55 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 18 July 2018 |
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