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Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus
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Brooks, L. A., Tidy, J. A., Gusterson, B., Hiller, Louise, O’Nions, J., Gasco, M., Marin, M. C., Farrell, P. J., Kaelin, Jr. and Crook, T. (2000) Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus. Cancer Research, 60 (24). pp. 6875-6877. ISSN 0008-5472.
An open access version can be found in:
Official URL: http://cancerres.aacrjournals.org/content/60/24/68...
Abstract
We have sought to determine the basis for preferential loss of the codon 72 proline (72P) rather than the arginine (72R) allele in squamous cell carcinoma of the vulva with loss of heterozygosity (LOH) in p53. The proportion of cases containing human papillomavirus (HPV) 16 was not statistically different among individuals with either 72RR or 72RP in the germ line (P > 0.99), but p53 LOH was significantly more common in individuals heterozygous 72RP than in 72RR individuals (P = 0.04). LOH more commonly involved the 72P allele in both HPV-positive and HPV-negative cancers. Our results imply that preferential loss of the 72P allele in vulval squamous cell carcinoma occurs by HPV-dependent and -independent mechanisms.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Cancer Research | ||||||
| Publisher: | American Association for Cancer Research | ||||||
| ISSN: | 0008-5472 | ||||||
| Official Date: | December 2000 | ||||||
| Dates: |
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| Volume: | 60 | ||||||
| Number: | 24 | ||||||
| Page Range: | pp. 6875-6877 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Open Access Version: |
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