The Library
Carbonic anhydrase IX, a marker of hypoxia : correlation with clinical outcome in transitional cell carcinoma of the bladder
Tools
Tools
Tools
Hussain, S. A., Palmer, D. H., Ganesan, R., Hiller, Louise, Gregory, J., Murray, P. G., Pastorek, J., Young, L. and James, N. D. (2004) Carbonic anhydrase IX, a marker of hypoxia : correlation with clinical outcome in transitional cell carcinoma of the bladder. Oncology Reports, 11 (5). pp. 1005-1010. doi:10.3892/or.11.5.1005 ISSN 1021-335X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: https://doi.org/10.3892/or.11.5.1005
Abstract
The purpose of this study was to investigate the effects of expression of CA IX, a marker of hypoxia, on outcome in bladder cancer. Immunohistochemistry was used to examine expression of CA IX in archival tissues of patients included in various therapeutic trials for transitional cell carcinoma (TCC) of the bladder. Data were collected on 57 patients who first presented with either invasive or superficial bladder cancer. Median follow-up for the 19 alive patients was 110 months (range 12 months to 14 years and 7 months). Median survival was 48 months (95% CI 35-110 months). Median survivals based on CA IX expression were as follows: there was a non-significant trend towards shorter survival for tumour expressing CA IX weakly (median 45 vs. 70 months, p=0.21). The hazard ratio for this variable is 1.5 (95% CI 0.8-3.0). Significantly more superficial bladder cancers than invasive cancers strongly expressed CA IX (82% vs. 52%; p=0.03). For non-invasive bladder cancer (n=28), CA IX positive patients had a median survival of 111 months while the median has not yet been achieved for CA IX negative patients (p=0.9). For invasive bladder cancer (n=29), CA IX positive patients had a median survival of 18 months as compared to 26 months for CA IX negative patients (p=0.94). There was a trend towards longer survival for tumour expressing CA IX strongly. This is likely to be a reflection of the significantly higher rate of strong CA IX expression in non-invasive cancers influencing these survival data.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
| Journal or Publication Title: | Oncology Reports | ||||
| Publisher: | Spandidos Publications | ||||
| ISSN: | 1021-335X | ||||
| Official Date: | 1 May 2004 | ||||
| Dates: |
|
||||
| Volume: | 11 | ||||
| Number: | 5 | ||||
| Page Range: | pp. 1005-1010 | ||||
| DOI: | 10.3892/or.11.5.1005 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
