UKADS Study Group (Including: Bellary, S., O'Hare, J. Paul, Raymond, Neil T., Gumber, Anil, Mughal, S., Szczepura, Ala, Kumar, Sudhesh and Barnett, A. H.). (2008) Effectiveness of enhanced diabetes care to patients of South Asian ethnicity : the United Kingdom Asian Diabetes Study (UKADS) : a cluster randomised controlled trial. Lancet, Vol.371 (No.9626). pp. 1769-1776. doi:10.1016/S0140-6736(08)60764-3 ISSN 0140-6736.

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Abstract

Background: Delivering high quality and evidence based healthcare to deprived sectors of the community is a major goal for society. We investigated the effectiveness of a culturally sensitive enhanced care package in UK general practice in improving cardiovascular risk factors in South Asian patients with type 2 diabetes.
Methods: 21 inner city practices were randomised to intervention (enhanced practice nurse time, link worker and diabetes specialist nurse support) (n=868) or control (standard care) (n=618) groups. Prescribing algorithms with clearly defined targets were provided for all practices. Main outcome measures comprised changes in blood pressure, total cholesterol and glycaemic control (HbA1c) after 2 years.
Findings: At baseline, groups were similar with respect to age, sex and cardiovascular risk factors.
Comparing treatment groups, after adjustment for confounders, and clustering, differences in diastolic blood pressure (1.91mmHg, P=0.0001) and mean arterial pressure (1.36mmHg, P=0.0180) were significant. There were no significant differences between groups for total cholesterol or HbA1c. Economic analysis indicates the nurse-led intervention was not cost-effective.
Across the whole study population systolic blood pressure, diastolic blood pressure and cholesterol decreased significantly by 4.9mmHg, 3.8mmHg and 0.45mmol/L respectively, but there was no change in HbA1c.
Interpretation: Additional, although limited, benefits were observed from our culturally enhanced care package over and above the secular changes achieved in the UK in recent years. Stricter targets in general practice and further measures to motivate patients are needed to maximise healthcare outcomes in South Asian patients with diabetes.

Item Type:	Journal Article
Alternative Title:	Enhanced diabetes care to patients of south Asian ethnic origin (the United Kingdom Asian Diabetes Study) : a cluster randomised controlled trial
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Diabetes -- Treatment -- Great Britain, Asians -- Great Britain, Minorities -- Health and hygiene -- Great Britain
Journal or Publication Title:	Lancet
Publisher:	Elsevier
ISSN:	0140-6736
Official Date:	2008
Dates:	Date Event 2008 Published
Volume:	Vol.371
Number:	No.9626
Page Range:	pp. 1769-1776
DOI:	10.1016/S0140-6736(08)60764-3
Status:	Peer Reviewed
Access rights to Published version:	Open Access (Creative Commons)
Description:	Version accepted by publisher (post-print, after peer review, before copy-editing).
Funder:	Pfizer Inc., Sanofi Aventis (Firm), Servier Laboratories UK, Schering-Plough Corporation, Takeda UK (Firm), Roche, Merck Pharma, Daiichi-Sankyo UK, Boehringer Ingelheim Pharmaceuticals, Eli Lilly International Foundation, Novo Nordisk, Bristol-Meyers Squibb, Solvay Health Care, Assurance Medical Society UK, Merck Sharp & Dohme
Related URLs:	Publisher

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