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The orexin/receptor system : molecular mechanism and therapeutic potential for neurological diseases
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Wang, Chunmei, Wang, Qinqin, Ji, Bingyuan, Pan, Yanyou, Xu, Chao, Cheng, Baohua, Bai, Bo and Chen, Jing (2018) The orexin/receptor system : molecular mechanism and therapeutic potential for neurological diseases. Frontiers in Molecular Neuroscience, 11 . p. 220. doi:10.3389/fnmol.2018.00220 ISSN 1662-5099.
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WRAP-orexin-receptor-system-molecular-mechanism-diseases-Chen-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2443Kb) | Preview |
Official URL: https://doi.org/10.3389/fnmol.2018.00220
Abstract
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein-coupled receptors (GPCRs), orexin receptor type 1 (OX1R) and type 2 (OX2R). Orexin/receptor pathways play vital regulatory roles in many physiological processes, especially feeding behavior, sleep-wake rhythm, reward and addiction and energy balance. Furthermore several reports showed that orexin/receptor pathways are involved in pathological processes of neurological diseases such as narcolepsy, depression, ischemic stroke, drug addiction and Alzheimer's disease (AD). This review article summarizes the expression patterns, physiological functions and potential molecular mechanisms of the orexin/receptor system in neurological diseases, providing an overall framework for considering these pathways from the standpoints of basic research and clinical treatment of neurological diseases.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Nervous system -- Diseases -- Treatment, Nervous system -- Diseases -- Molecular aspects, Orexins, Neurotransmitter receptors, Neuroprotective agents, G proteins | ||||||||||||||||||
Journal or Publication Title: | Frontiers in Molecular Neuroscience | ||||||||||||||||||
Publisher: | Frontiers Research Foundation | ||||||||||||||||||
ISSN: | 1662-5099 | ||||||||||||||||||
Official Date: | 28 June 2018 | ||||||||||||||||||
Dates: |
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Volume: | 11 | ||||||||||||||||||
Page Range: | p. 220 | ||||||||||||||||||
DOI: | 10.3389/fnmol.2018.00220 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. ** History: received 12-04-2018; accepted 06-06-2018. | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 16 August 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 16 August 2018 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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