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Efficient binding, protection, and self-release of dsRNA in soil by linear and star cationic polymers
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Whitfield, Richard, Anastasaki, Athina, Truong, Nghia P., Cook, Alexander B., Omedes-Pujol, Marta, Loczenski Rose, Vanessa, Nguyen, Tuan A. H., Burns, James A., Perrier, Sébastien, Davis, Thomas P. and Haddleton, David M. (2018) Efficient binding, protection, and self-release of dsRNA in soil by linear and star cationic polymers. ACS Macro Letters, 7 (8). pp. 909-915. doi:10.1021/acsmacrolett.8b00420 ISSN 2161-1653.
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Official URL: http://dx.doi.org/10.1021/acsmacrolett.8b00420
Abstract
Double stranded RNA (dsRNA) exhibits severe degradation within 3 days in live soil, limiting its potential application in crop protection. Herein we report the efficient binding, protection, and self-release of dsRNA in live soil through the usage of a cationic polymer. Soil stability assays show that linear poly(2-(dimethylamino)ethyl acrylate) can delay the degradation of dsRNA by up to 1 week while the star shaped analogue showed an increased stabilization of dsRNA by up to 3 weeks. Thus, the architecture of the polymer can significantly affect the lifetime of dsRNA in soil. In addition, the hydrolysis and dsRNA binding and release profiles of these polymers were carefully evaluated and discussed. Importantly, hydrolysis could occur independently of environmental conditions (e.g., different pH, different temperature) showing the potential for many opportunities in agrochemicals where protection and subsequent self-release of dsRNA in live soil is required.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QP Physiology S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Double-stranded RNA -- Industrial applications, Polymers, Hydrolysis, Soils, Plants, Protection of | ||||||||||||||||||||||||
| Journal or Publication Title: | ACS Macro Letters | ||||||||||||||||||||||||
| Publisher: | American Chemical Society | ||||||||||||||||||||||||
| ISSN: | 2161-1653 | ||||||||||||||||||||||||
| Official Date: | 12 July 2018 | ||||||||||||||||||||||||
| Dates: |
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| Volume: | 7 | ||||||||||||||||||||||||
| Number: | 8 | ||||||||||||||||||||||||
| Page Range: | pp. 909-915 | ||||||||||||||||||||||||
| DOI: | 10.1021/acsmacrolett.8b00420 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsmacrolett.8b00420 | ||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
| Date of first compliant deposit: | 8 August 2018 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 12 June 2019 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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