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Efficient binding, protection, and self-release of dsRNA in soil by linear and star cationic polymers

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Whitfield, Richard, Anastasaki, Athina, Truong, Nghia P., Cook, Alexander B., Omedes-Pujol, Marta, Loczenski Rose, Vanessa, Nguyen, Tuan A. H., Burns, James A., Perrier, Sébastien, Davis, Thomas P. and Haddleton, David M. (2018) Efficient binding, protection, and self-release of dsRNA in soil by linear and star cationic polymers. ACS Macro Letters, 7 (8). pp. 909-915. doi:10.1021/acsmacrolett.8b00420 ISSN 2161-1653.

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Official URL: http://dx.doi.org/10.1021/acsmacrolett.8b00420

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Abstract

Double stranded RNA (dsRNA) exhibits severe degradation within 3 days in live soil, limiting its potential application in crop protection. Herein we report the efficient binding, protection, and self-release of dsRNA in live soil through the usage of a cationic polymer. Soil stability assays show that linear poly(2-(dimethylamino)ethyl acrylate) can delay the degradation of dsRNA by up to 1 week while the star shaped analogue showed an increased stabilization of dsRNA by up to 3 weeks. Thus, the architecture of the polymer can significantly affect the lifetime of dsRNA in soil. In addition, the hydrolysis and dsRNA binding and release profiles of these polymers were carefully evaluated and discussed. Importantly, hydrolysis could occur independently of environmental conditions (e.g., different pH, different temperature) showing the potential for many opportunities in agrochemicals where protection and subsequent self-release of dsRNA in live soil is required.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
S Agriculture > SB Plant culture
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Double-stranded RNA -- Industrial applications, Polymers, Hydrolysis, Soils, Plants, Protection of
Journal or Publication Title: ACS Macro Letters
Publisher: American Chemical Society
ISSN: 2161-1653
Official Date: 12 July 2018
Dates:
DateEvent
12 July 2018Published
9 July 2018Accepted
Volume: 7
Number: 8
Page Range: pp. 909-915
DOI: 10.1021/acsmacrolett.8b00420
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsmacrolett.8b00420
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 8 August 2018
Date of first compliant Open Access: 12 June 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
CE140100036[ARC] Australian Research Councilhttp://dx.doi.org/10.13039/501100000923
DE180100076[ARC] Australian Research Councilhttp://dx.doi.org/10.13039/501100000923
UNSPECIFIEDSyngenta Internationalhttp://dx.doi.org/10.13039/501100010761
UNSPECIFIEDH2020 Marie Skłodowska-Curie ActionsUNSPECIFIED
UQECR1720169University of Queenslandhttp://dx.doi.org/10.13039/501100001794
WM130055[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288

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