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Complex interactions in soil-transmitted helminth co-infections from a cross-sectional study in Sri Lanka
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Lepper, Hannah, Prada, Joaquín M., Davis, Emma L., Gunawardena, Sharmini A. and Hollingsworth, T. Déirdre (2018) Complex interactions in soil-transmitted helminth co-infections from a cross-sectional study in Sri Lanka. Transactions of the Royal Society of Tropical Medicine and Hygiene, 112 (8). pp. 397-404. doi:10.1093/trstmh/try068 ISSN 0035-9203.
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Official URL: https://doi.org/10.1093/trstmh/try068
Abstract
Co-infection with multiple soil-transmitted helminth (STH) species is common in communities with a high STH prevalence. The life histories of STH species share important characteristics, particularly in the gut, and there is the potential for interaction, but evidence on whether interactions may be facilitating or antagonistic are limited.Data from a pretreatment cross-sectional survey of STH egg deposition in a tea plantation community in Sri Lanka were analysed to evaluate patterns of co-infection and changes in egg deposition.There were positive associations between Trichuris trichiura (whipworm) and both Necator americanus (hookworm) and Ascaris lumbricoides (roundworm), but N. americanus and Ascaris were not associated. N. americanus and Ascaris infections had lower egg depositions when they were in single infections than when they were co-infecting. There was no clear evidence of a similar effect of co-infection in Trichuris egg deposition.Associations in prevalence and egg deposition in STH species may vary, possibly indicating that effects of co-infection are species dependent. We suggest that between-species interactions that differ by species could explain these results, but further research in different populations is needed to support this theory.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Transactions of the Royal Society of Tropical Medicine and Hygiene | ||||||||
Publisher: | Elsevier Ltd | ||||||||
ISSN: | 0035-9203 | ||||||||
Official Date: | 1 August 2018 | ||||||||
Dates: |
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Volume: | 112 | ||||||||
Number: | 8 | ||||||||
Page Range: | pp. 397-404 | ||||||||
DOI: | 10.1093/trstmh/try068 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | ** From Europe PMC via Jisc Publications Router. ** Licence for this article: cc by | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 25 September 2018 | ||||||||
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