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Role of membrane environment and membrane-spanning protein regions in assembly and function of the Class II Major Histocompatibility complex
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Dixon, Ann M. and Roy, Syamal (2019) Role of membrane environment and membrane-spanning protein regions in assembly and function of the Class II Major Histocompatibility complex. Human Immunology, 80 (1). pp. 5-14. doi:10.1016/j.humimm.2018.07.004 ISSN 0198-8859.
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Official URL: https://doi.org/10.1016/j.humimm.2018.07.004
Abstract
Class II Major Histocompatibility complex (MHC-II) is a polymorphic heterodimer that binds antigen-derived peptides and presents them on the surface of antigen presenting cells. This mechanism of antigen presentation leads to recognition by CD4 T-cells and T-cell activation, making it a critical element of adaptive immune response. For this reason, the structural determinants of MHC-II function have been of great interest for the past 30 years, resulting in a robust structural understanding of the extracellular regions of the complex. However, the membrane-localized regions have also been strongly implicated in protein-protein and protein-lipid interactions that facilitate Class II assembly, transport and function, and it is these regions that are the focus of this review. Here we describe studies that reveal the strong and selective interactions between the transmembrane domains of the MHC α, and invariant chains which, when altered, have broad reaching impacts on antigen presentation and Class II function. We also summarize work that clearly demonstrates the link between membrane lipid composition (particularly the presence of cholesterol) and MHC-II conformation, subsequent peptide binding, and downstream T-cell activation. We have integrated these studies into a comprehensive view of Class II transmembrane domain biology. [Abstract copyright: Copyright © 2018. Published by Elsevier Inc.]
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Major histocompatibility complex, Antigen presenting cells, Membrane proteins, Membrane lipids, Immune response | |||||||||
Journal or Publication Title: | Human Immunology | |||||||||
Publisher: | Elsevier Science BV | |||||||||
ISSN: | 0198-8859 | |||||||||
Official Date: | January 2019 | |||||||||
Dates: |
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Volume: | 80 | |||||||||
Number: | 1 | |||||||||
Page Range: | pp. 5-14 | |||||||||
DOI: | 10.1016/j.humimm.2018.07.004 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 1 November 2018 | |||||||||
Date of first compliant Open Access: | 10 August 2019 | |||||||||
RIOXX Funder/Project Grant: |
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