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Genomic investigation of a Mycobacterium tuberculosis outbreak involving prison and community cases in Florida, United States
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Séraphin, Marie Nancy, Khan, Md. Siddiqur Rahman, Didelot, Xavier, Morris, J. Glenn, Nolan, David J., Murray, Ellen R., Salemi, Marco, Lauzardo, Michael and May, Justin R. (2018) Genomic investigation of a Mycobacterium tuberculosis outbreak involving prison and community cases in Florida, United States. The American Journal of Tropical Medicine and Hygiene, 99 (4). doi:10.4269/ajtmh.17-0700 ISSN 0002-9637.
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Official URL: http://dx.doi.org/10.4269/ajtmh.17-0700
Abstract
We used whole-genome sequencing to investigate a tuberculosis outbreak involving U.S.-born persons in the prison system and both U.S.- and foreign-born persons in the community in Florida over a 7-year period (2009–2015). Genotyping by spacer oligonucleotide typing and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat suggested that the outbreak might be clonal in origin. However, contact tracing could not link the two populations. Through a multidisciplinary approach, we showed that the cluster involved distinct bacterial transmission networks segregated by country of birth. The source strain is of foreign origin and circulated in the local Florida community for more than 20 years before introduction into the prison system. We also identified novel transmission links involving foreign and U.S.-born cases not discovered during contact investigation. Our data highlight the potential for spread of strains originating from outside the United States into U.S. “high-risk” populations, such as prisoners, with subsequent movement back to the general community.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | The American Journal of Tropical Medicine and Hygiene | ||||||
Publisher: | American Society of Tropical Medicine and Hygiene | ||||||
ISSN: | 0002-9637 | ||||||
Official Date: | October 2018 | ||||||
Dates: |
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Volume: | 99 | ||||||
Number: | 4 | ||||||
DOI: | 10.4269/ajtmh.17-0700 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
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