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Coordinating Rho and Rac : the regulation of Rho GTPase signaling and cadherin junctions
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Ratheesh, Aparna, Priya, Rashmi and Yap, Alpha S. (2013) Coordinating Rho and Rac : the regulation of Rho GTPase signaling and cadherin junctions. Progress in Molecular Biology and Translational Science, 116 . pp. 49-68. doi:10.1016/B978-0-12-394311-8.00003-0 ISSN 1877-1173.
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Official URL: http://dx.doi.org/10.1016/B978-0-12-394311-8.00003...
Abstract
Cadherin-based cell–cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell–cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, operation of classical cadherin adhesion systems is coordinated with cytoskeletal dynamics, contractility, and membrane trafficking to support productive interactions. Cadherin-based cell signaling is critical for the coordination of these many cellular processes. Here, we discuss the role of Rho family GTPases in cadherin signaling. We focus on understanding the pathways that utilize Rac and Rho in junctional biology, aiming to identify the mechanisms of upstream regulation and define how the effects of these activated GTPases might regulate the actin cytoskeleton to modulate the cellular processes involved in cadherin-based cell–cell interactions.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Progress in Molecular Biology and Translational Science | ||||
Publisher: | Academic Press | ||||
ISSN: | 1877-1173 | ||||
Book Title: | The Molecular Biology of Cadherins | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | 116 | ||||
Page Range: | pp. 49-68 | ||||
DOI: | 10.1016/B978-0-12-394311-8.00003-0 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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