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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
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UNSPECIFIED (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. CELL, 109 (3). pp. 321-334. ISSN 0092-8674.
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Abstract
To explore the role of c-Myc in carcinogenesis, we have developed a reversible transgenic model of pancreatic beta cell oncogenesis using a switchable form of the c-Myc protein. Activation of c-Myc in adult, mature beta cells induces uniform beta cell proliferation but is accompanied by overwhelming apoptosis that rapidly erodes beta cell mass. Thus, the oncogenic potential of c-Myc in beta cells is masked by apoptosis. Upon suppression of c-Myc-induced beta cell apoptosis by coexpression Of Bcl-X-L, c-Myc triggers rapid and uniform progression into angiogenic, invasive tumors. Subsequent c-Myc deactivation induces rapid regression associated with vascular degeneration and beta cell apoptosis. Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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Journal or Publication Title: | CELL | ||||
Publisher: | CELL PRESS | ||||
ISSN: | 0092-8674 | ||||
Official Date: | 3 May 2002 | ||||
Dates: |
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Volume: | 109 | ||||
Number: | 3 | ||||
Number of Pages: | 14 | ||||
Page Range: | pp. 321-334 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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