The Library
A molecular genetic analysis of L-asparaginase II synthesis in Erwinia Chrysanthemi NCPPB 1066
Tools
Tools
Tools
Kell, Christopher Martin (1991) A molecular genetic analysis of L-asparaginase II synthesis in Erwinia Chrysanthemi NCPPB 1066. PhD thesis, University of Warwick.
|
PDF
WRAP_Theses_Kell_1991.pdf - Submitted Version - Requires a PDF viewer. Download (15Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3231790~S15
Abstract
The enzyme L-asparaginase (L-asparagine amidohydrolase EC 3.5.1.1) has been shown to possess antitumour activity and has been extensively used over many years for the treatment of childhood acute lymphoblastic leukaemia. Today, this enzyme is produced commercially from either the enteric bacterium Escherichia coll or the plant pathogen Erwinla chrysanthemi NCPPB 1066.
The following sections of this chapter have been written in the form of a review which summarises the available literature concerning L- asparaginase. The clinical, physical, biochemical, commercial and regulatory aspects of this enzyme are discussed, with particular emphasis on the chemotherapeutic L-asparaginase from Er. chrysanthemi NCPPB 1066, since this is the subject of the present study, in addition, the reader is introduced to the genus Erwinla and to the variety of tools that have been developed for the genetic analysis of a number of Erwinia species.
| Item Type: | Thesis or Dissertation (PhD) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QK Botany S Agriculture > SB Plant culture |
||||
| Library of Congress Subject Headings (LCSH): | Plant-pathogen relationships, Plant-pathogen relationships -- Genetic aspects, Phytopathogenic fungi, Brown rot fungi of fruit | ||||
| Official Date: | September 1991 | ||||
| Dates: |
|
||||
| Institution: | University of Warwick | ||||
| Theses Department: | Department of Biological Sciences | ||||
| Thesis Type: | PhD | ||||
| Publication Status: | Unpublished | ||||
| Supervisor(s)/Advisor: | Salmond, George ; Minton, Nigel P. | ||||
| Sponsors: | Science and Engineering Research Council (Great Britain) | ||||
| Format of File: | |||||
| Extent: | xxix, 431 leaves : illustrations | ||||
| Language: | eng |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
