Kell, Christopher Martin (1991) A molecular genetic analysis of L-asparaginase II synthesis in Erwinia Chrysanthemi NCPPB 1066. PhD thesis, University of Warwick.

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Abstract

The enzyme L-asparaginase (L-asparagine amidohydrolase EC 3.5.1.1) has been shown to possess antitumour activity and has been extensively used over many years for the treatment of childhood acute lymphoblastic leukaemia. Today, this enzyme is produced commercially from either the enteric bacterium Escherichia coll or the plant pathogen Erwinla chrysanthemi NCPPB 1066.

The following sections of this chapter have been written in the form of a review which summarises the available literature concerning L- asparaginase. The clinical, physical, biochemical, commercial and regulatory aspects of this enzyme are discussed, with particular emphasis on the chemotherapeutic L-asparaginase from Er. chrysanthemi NCPPB 1066, since this is the subject of the present study, in addition, the reader is introduced to the genus Erwinla and to the variety of tools that have been developed for the genetic analysis of a number of Erwinia species.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QK Botany S Agriculture > SB Plant culture
Library of Congress Subject Headings (LCSH):	Plant-pathogen relationships, Plant-pathogen relationships -- Genetic aspects, Phytopathogenic fungi, Brown rot fungi of fruit
Official Date:	September 1991
Dates:	Date Event September 1991 UNSPECIFIED
Institution:	University of Warwick
Theses Department:	Department of Biological Sciences
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Salmond, George ; Minton, Nigel P.
Sponsors:	Science and Engineering Research Council (Great Britain)
Format of File:	pdf
Extent:	xxix, 431 leaves : illustrations
Language:	eng

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