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Interrogating metabolism as an electron flow system
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Zerfaß, Christian, Asally, Munehiro and Soyer, Orkun S. (2019) Interrogating metabolism as an electron flow system. Current Opinion in Systems Biology, 13 . pp. 59-67. doi:10.1016/j.coisb.2018.10.001 ISSN 2452-3100.
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WRAP-interrogatin-metabolism-electron-flow-system-Soyer-2018.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1099Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.coisb.2018.10.001
Abstract
Metabolism is generally considered as a neatly organised system of modular pathways, shaped by evolution under selection for optimal cellular growth. This view falls short of explaining and predicting a number of key observations about the structure and dynamics of metabolism. We highlight these limitations of a pathway-centric view on metabolism and summarise studies suggesting how these could be overcome by viewing metabolism as a thermodynamically and kinetically constrained, dynamical flow system. Such a systems-level, first-principles based view of metabolism can open up new avenues of metabolic engineering and cures for metabolic diseases and allow better insights to a myriad of physiological processes that are ultimately linked to metabolism. Towards further developing this view, we call for a closer interaction among physical and biological disciplines and an increased use of electrochemical and biophysical approaches to interrogate cellular metabolism together with the microenvironment in which it exists.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Metabolism, Physiology | ||||||||||||
| Journal or Publication Title: | Current Opinion in Systems Biology | ||||||||||||
| Publisher: | Elsevier | ||||||||||||
| ISSN: | 2452-3100 | ||||||||||||
| Official Date: | February 2019 | ||||||||||||
| Dates: |
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| Volume: | 13 | ||||||||||||
| Page Range: | pp. 59-67 | ||||||||||||
| DOI: | 10.1016/j.coisb.2018.10.001 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Date of first compliant deposit: | 31 October 2018 | ||||||||||||
| Date of first compliant Open Access: | 24 October 2019 | ||||||||||||
| RIOXX Funder/Project Grant: |
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